2,4,5-三氟苯乙酸的合成研究进展
|
摘要
2,4,5-三氟苯乙酸是二肽基肽酶-IV抑制剂类糖尿病治疗药物西他列汀的关键中间体,本文总结并评述了2,4,5-三氟苯乙酸的合成方法。
2,4,5-Trifluorophenylacetic acid is a key intermediate to the dipeptidyl peptidase( DPP)-IV inhibitor anti-diabetic drug sitagliptin. This review summarized and commented on the synthetic methods of 2,4,5-trifluorophenylacetic acid.
2,4,5-Trifluorophenylacetic acid is a key intermediate to the dipeptidyl peptidase( DPP)-IV inhibitor anti-diabetic drug sitagliptin. This review summarized and commented on the synthetic methods of 2,4,5-trifluorophenylacetic acid.
引文
[1]夏玲红.治疗糖尿病的新药西他列汀[J].中国新药杂志,2007,16(12):979-981.
[2]张立宏,王莉莉,李彬.二肽基肽酶-IV抑制剂药理学作用及机制的研究进展[J].中国新药杂志,2009,18(11):1000-1004.
[3]孙桂芳,蔡正艳,周伟澄.西他列汀合成路线图解[J].中国医药工业杂志,2008,39(5):383-386.
[4]Hansen K B,Hsiao Y,Xu F,et al.Highly efficient asymmetric synthesis of sitagliptin[J].J Am Chem Soc,2009,131:8 798-8 804.
[5]Desai A A.Sitagliptin manufacture:a compelling tale of green chemistry,process intensification,and industrial asymmetric catalysis[J].Angew Chem Int.Ed Engl,2011,50:1 974-1 976.
[6]张群辉,黄明旺,陶开跃.三氟苯乙酸和西他列汀的制备方法[P].CN:101429115,2009-05-13.
[7]冯秀娟,谭君,杨帆,等.一种2,4,5-三氟苯乙酸的制备方法[P].CN:101823952,2010-09-08.
[8]钟建新,何人宝.2,4,5-三氟苯乙酸的制备方法[P].CN:101092345,2007-12-26.
[9]何人宝,王莺妹,金逸中,等.2,4,5-三氟苯乙酸的合成[J].化工生产与技术,2011,18(3):4-6.
[10]李燕,彭光荣,袁云龙,等.2,4,5-三氟苯乙酸的制备方法[P].CN:1749232,2006-03-22.
[11]刘一超,王秀云,孙为仁,等.2,4,5-三氟苄氯和2,4,5-三氟苯乙酸的制备方法[P].CN:102690166,2012-09-26.
[12]钟建新,邵鸿鸣.2,4,5-三氟苯乙酸的制备方法[P].CN:101659611,2010-03-03.
[13]张鹏翔,张月成,李志陵,等.一种2,4,5-三氟苯乙酸的制备方法[P].CN:102584565,2012-07-18.
[14]陈再新,夏正君,蒋龙,等.制备2,4,5-三氟苯乙酸的新方法[P].CN:101244994,2008-08-20.
[15]Falchi A,Stivanello M,Serafini S.Process for the preparation of fluorophenylacetic acids and derivatives thereof[P].WO:2008/078350,2008-07-03.
[16]刘泽玲.2,4,5-三氟苯乙酸的合成研究[J].河北工业科技,2011,28(4):244-246.
[17]Stamford A W,Gilbert E J,Cumming J N.Pyrrolidinefused thiadiazine dioxide compounds as BACE inhibitors,compositions,and their use[P].US:2014/023667,2014-01-23.
[18]张显飞,李功勇,张国鑫,等.三氟苯乙酸的制备方法[P].CN:101450895,2009-06-10.
[19]Ikemoto N,Dreher S D.Process for the synthesis of trifluorophenylacetic acids[P].US:2004077901,2004-04-22.
[20]Kim N D,Chang J Y,Jung J H,et al.Method for preparing intermediate of sitagliptin using chiral oxirane[P].WO:2011/040717,2011-04-07.
[21]Armstrong J D,Dreher S D,Ikemoto N.Process for the synthesis of trifluorophenylacetic acids[P].US:2004/068141,2004-04-08.
[22]郑土才,吾国强,吕延文.一种2,4,5-三氟苯乙酸的制备方法[P].CN 103012111,2012-09-12.
[23]鲍樟水,冯启,夏旭建,等.2,4,5-三氟苯乙酸的合成[J].浙江化工,2014,45(1):4-6.
[2]张立宏,王莉莉,李彬.二肽基肽酶-IV抑制剂药理学作用及机制的研究进展[J].中国新药杂志,2009,18(11):1000-1004.
[3]孙桂芳,蔡正艳,周伟澄.西他列汀合成路线图解[J].中国医药工业杂志,2008,39(5):383-386.
[4]Hansen K B,Hsiao Y,Xu F,et al.Highly efficient asymmetric synthesis of sitagliptin[J].J Am Chem Soc,2009,131:8 798-8 804.
[5]Desai A A.Sitagliptin manufacture:a compelling tale of green chemistry,process intensification,and industrial asymmetric catalysis[J].Angew Chem Int.Ed Engl,2011,50:1 974-1 976.
[6]张群辉,黄明旺,陶开跃.三氟苯乙酸和西他列汀的制备方法[P].CN:101429115,2009-05-13.
[7]冯秀娟,谭君,杨帆,等.一种2,4,5-三氟苯乙酸的制备方法[P].CN:101823952,2010-09-08.
[8]钟建新,何人宝.2,4,5-三氟苯乙酸的制备方法[P].CN:101092345,2007-12-26.
[9]何人宝,王莺妹,金逸中,等.2,4,5-三氟苯乙酸的合成[J].化工生产与技术,2011,18(3):4-6.
[10]李燕,彭光荣,袁云龙,等.2,4,5-三氟苯乙酸的制备方法[P].CN:1749232,2006-03-22.
[11]刘一超,王秀云,孙为仁,等.2,4,5-三氟苄氯和2,4,5-三氟苯乙酸的制备方法[P].CN:102690166,2012-09-26.
[12]钟建新,邵鸿鸣.2,4,5-三氟苯乙酸的制备方法[P].CN:101659611,2010-03-03.
[13]张鹏翔,张月成,李志陵,等.一种2,4,5-三氟苯乙酸的制备方法[P].CN:102584565,2012-07-18.
[14]陈再新,夏正君,蒋龙,等.制备2,4,5-三氟苯乙酸的新方法[P].CN:101244994,2008-08-20.
[15]Falchi A,Stivanello M,Serafini S.Process for the preparation of fluorophenylacetic acids and derivatives thereof[P].WO:2008/078350,2008-07-03.
[16]刘泽玲.2,4,5-三氟苯乙酸的合成研究[J].河北工业科技,2011,28(4):244-246.
[17]Stamford A W,Gilbert E J,Cumming J N.Pyrrolidinefused thiadiazine dioxide compounds as BACE inhibitors,compositions,and their use[P].US:2014/023667,2014-01-23.
[18]张显飞,李功勇,张国鑫,等.三氟苯乙酸的制备方法[P].CN:101450895,2009-06-10.
[19]Ikemoto N,Dreher S D.Process for the synthesis of trifluorophenylacetic acids[P].US:2004077901,2004-04-22.
[20]Kim N D,Chang J Y,Jung J H,et al.Method for preparing intermediate of sitagliptin using chiral oxirane[P].WO:2011/040717,2011-04-07.
[21]Armstrong J D,Dreher S D,Ikemoto N.Process for the synthesis of trifluorophenylacetic acids[P].US:2004/068141,2004-04-08.
[22]郑土才,吾国强,吕延文.一种2,4,5-三氟苯乙酸的制备方法[P].CN 103012111,2012-09-12.
[23]鲍樟水,冯启,夏旭建,等.2,4,5-三氟苯乙酸的合成[J].浙江化工,2014,45(1):4-6.