围放疗期子宫颈鳞癌患者血清SCC-Ag水平变化的研究
摘要
目的研究围放疗期子宫颈鳞癌血清鳞状上皮细胞癌抗原(SCC-Ag)水平变化。方法纳入子宫颈鳞癌患者134例,分析其放疗前后的血清SCC-Ag改变。结果 134例子宫颈鳞癌患者中,体外调强放疗前有97例(72.4%)存在血清SCC-Ag水平改变情况,子宫颈鳞癌Ⅰ~Ⅲ期患者血清SCC-Ag阳性率差异无统计学意义(P>0.05);体外调强放疗前Ⅰ期、Ⅱ期患者血清SCC-Ag水平与Ⅲ期患者比较差异有统计学意义(P<0.05);腔内后装放疗前、腔内后装放疗后,Ⅰ~Ⅲ期患者血清SCC-Ag水平比较差异无统计学意义(P>0.05)。结论血清SCC-Ag检测对于子宫颈鳞癌的诊断有较好的辅助作用,而对于子宫颈鳞癌发病严重程度的判定不够精确。
引文
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[3]王英,李佩章,朱波,等.应用Logistic回归和ROC曲线综合评价肿瘤标志物联合检测对肺癌的诊断价值[J].中国现代医学杂志,2015,25(19):47-50.
[4]王红霞,丁晓萍,侯庆香,等.SCC-Ag在宫颈癌新辅助化疗前后的改变及临床意义[J].中国妇产科临床杂志,2015,(3):229-232.
[5]曾艳,安贵峰,梁桂云.血清鳞状细胞癌抗原在宫颈鳞状细胞癌中的意义[J].实用临床医药杂志,2015,19(13):56-58.
[6]陈文娟,潘建基,江楠.鳞状细胞相关抗原在宫颈癌同步放化疗中的表达及意义[J].中国医药指南,2013,8(22):26-28.
[7]Jeong BK,Huh SJ,Choi DH,et al.Prognostic value of different patterns of squamous cell carcinoma antigen level for the recurrent cervical cancer[J].Cancer Res Trea,2013,45(1):48-54.
[8]Ryuji K,Naoto F,Hiroshi K,et al.Posttreatment cut-off levels of squamous cell carcinoma antigen as a prognostic factor in patients with locally advanced cervical cancer treated with radiotherapy[J].J Gynecol Oncol,2013,24(4):313-320.
[9]Narayan K,Lin MY.Staging for cervix cancer:Role of radiology,surgery and clinical assessment[J].Best Pract Res Clin Obstet Gynaecol,2015,29(6):833-844.
[10]李群,刘淑玉,刘红丽,等.血清鳞状细胞癌抗原水平变化在诊断子宫颈鳞癌复发中的临床意义[J].中华妇产科杂志,2015,50(2):131-136.
[11]Ryu HK,Baek JS,Kang WD,et al.The prognostic value of squamous cell carcinoma antigen for predicting tumor recurrence in cervical squamous cell carcinoma patients.[J].Obstet Gynecol Sci,2015,58(5):368-376.