发酵品醇提物吸入粉雾剂处方筛选及性质表征研究
|
摘要
目的:研究全蝎、白术、蛴螬混合发酵品(SAHHFP)醇提物的吸入粉雾剂处方筛选及性质表征。方法:将SAHHFP醇提物冻干粉与乳糖按1∶1、1∶2、1∶3、3∶4的比例混合得到的喷雾干燥粉制成胶囊型吸入粉雾剂,通过对粒径、电位、流动性、吸湿性和吸入粉雾剂空气动力学有效沉积率的比较,得到两者的最佳配比。结果:SAHHFP醇提物冻干粉与乳糖按1∶1比例混合得到的喷雾干燥粉流动性、吸湿性和有效沉积率均优于另外三个比例。结论:SAHHFP醇提物冻干粉与乳糖按1∶1比例混合得到的喷雾干燥粉可以制成胶囊型吸入粉雾剂,且具有较好的稳定性。
Objective:To study the formulation and characterization of inhalation powders of the alcohol extracts of Quanxie(Scorpio),Baizhu(Atractylodis Macrocephalae Rhizoma) and Qicao(Holotrichiae Larva)(SAHHFP). Methods:The spray-dried powder obtained by mixing freeze-dried alcohol extractions from SAHHFP and lactose in a ratio of 1 ∶1,1∶2,1∶3,3∶4 was made into inhalation powder of capsule type,and through comparing the size,potential,fluidity,hygroscopicity and the aerodynamically effective deposition rate of the inhaled powder,the suitable ratio of SAHHFP to lactose was determined. Results:Compared with other ratios,when the ratio of SAHHFP to lactose was set at 1 ∶1,the product would be of the optimized fluidity,hygroscopicity and effective deposition rate. Conclusion:When the ratio of the freeze-dried alcohol extracts of SAHHFP to lactose is set at 1 ∶1,the obtained spray-dried powder can be made into inhalation powder of capsule type with better stability.
Objective:To study the formulation and characterization of inhalation powders of the alcohol extracts of Quanxie(Scorpio),Baizhu(Atractylodis Macrocephalae Rhizoma) and Qicao(Holotrichiae Larva)(SAHHFP). Methods:The spray-dried powder obtained by mixing freeze-dried alcohol extractions from SAHHFP and lactose in a ratio of 1 ∶1,1∶2,1∶3,3∶4 was made into inhalation powder of capsule type,and through comparing the size,potential,fluidity,hygroscopicity and the aerodynamically effective deposition rate of the inhaled powder,the suitable ratio of SAHHFP to lactose was determined. Results:Compared with other ratios,when the ratio of SAHHFP to lactose was set at 1 ∶1,the product would be of the optimized fluidity,hygroscopicity and effective deposition rate. Conclusion:When the ratio of the freeze-dried alcohol extracts of SAHHFP to lactose is set at 1 ∶1,the obtained spray-dried powder can be made into inhalation powder of capsule type with better stability.
引文
[1]史磊,张天锡,杜聪颖,等.中药全蝎活性成分、药理作用及临床应用研究进展[J].辽宁中医药大学学报,2015,17(4):89-91.
[2]张盼盼,焦方文,周建国,等.发酵全蝎粉酶解前后水提液抗病毒活性比较[J].中南药学,2016,14(3):267-269.
[3]张兵,张丽娜,韩鹏军,等.白术中3种内酯成分的含量测定及指纹图谱研究[J].天津中医药大学学报,2018,37(5):411-415.
[4]姜瑜.白术多糖及其硫酸化衍生物的抗病毒和增强免疫活性的比较[D].南京:南京农业大学,2011.
[5]颜娓娓,徐佳馨,王继锋,等.白头翁与蛴螬不同配伍比例体外抗病毒作用研究[J].长春中医药大学学报,2018,34(3):453-456.
[6]王美欣,胡海峰,薛亚平,等.球孢白僵菌在生物催化反应中的应用研究进展[J].化学与生物工程,2018,35(8):14-19.
[7]薛文东.影响吸入粉雾剂疗效发挥的因素分析[J].中国呼吸与危重监护杂志,2013,12(5):537-540.
[8]高蕾,马玉楠,王亚敏,等.吸入粉雾剂的处方与工艺研究解析[J].中国新药杂志,2018,27(9):984-987.
[9]王彦多,王立娜,桑晓,等.基于生物转化作用球孢白僵菌发酵土鳖虫抗肿瘤的研究[J].药学研究,2017,36(12):693-695,728.
[10]王守斌,王博,孙歆慧,等.吸入制剂的研究进展[J].现代药物与临床,2013,28(2):232-235.
[11]桂奇峰,张博,张树鹏,等.聚羧酸盐分散剂在农药水悬浮剂中的应用及作用机理分析[J].中国科学:化学,2016,46(11):1242-1248.
[12]王海,李同良,徐伟娜.阿托伐他汀钙片生产批量成倍放大工艺研究[J].药学研究,2018,37(8):466-468.
[13]徐华丽,陶志强,曾媛,等.盐酸溴己新吸入粉雾剂的质量与稳定性考察[J].中国药师,2018,21(6):1002-1006.
[14]王诗鹭,乔楚,刘桐.天麻超微粉胶囊的制备工艺研究[J].中国中医药现代远程教育,2018,16(16):75-77.
[15]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2015:951.
[16]程晓荟,吴瑶瑶,赵延慧,等.雌雄全蝎中蛋白质及多糖含量的测定与比较[J].山东农业科学,2016,48(3):130-132.
[2]张盼盼,焦方文,周建国,等.发酵全蝎粉酶解前后水提液抗病毒活性比较[J].中南药学,2016,14(3):267-269.
[3]张兵,张丽娜,韩鹏军,等.白术中3种内酯成分的含量测定及指纹图谱研究[J].天津中医药大学学报,2018,37(5):411-415.
[4]姜瑜.白术多糖及其硫酸化衍生物的抗病毒和增强免疫活性的比较[D].南京:南京农业大学,2011.
[5]颜娓娓,徐佳馨,王继锋,等.白头翁与蛴螬不同配伍比例体外抗病毒作用研究[J].长春中医药大学学报,2018,34(3):453-456.
[6]王美欣,胡海峰,薛亚平,等.球孢白僵菌在生物催化反应中的应用研究进展[J].化学与生物工程,2018,35(8):14-19.
[7]薛文东.影响吸入粉雾剂疗效发挥的因素分析[J].中国呼吸与危重监护杂志,2013,12(5):537-540.
[8]高蕾,马玉楠,王亚敏,等.吸入粉雾剂的处方与工艺研究解析[J].中国新药杂志,2018,27(9):984-987.
[9]王彦多,王立娜,桑晓,等.基于生物转化作用球孢白僵菌发酵土鳖虫抗肿瘤的研究[J].药学研究,2017,36(12):693-695,728.
[10]王守斌,王博,孙歆慧,等.吸入制剂的研究进展[J].现代药物与临床,2013,28(2):232-235.
[11]桂奇峰,张博,张树鹏,等.聚羧酸盐分散剂在农药水悬浮剂中的应用及作用机理分析[J].中国科学:化学,2016,46(11):1242-1248.
[12]王海,李同良,徐伟娜.阿托伐他汀钙片生产批量成倍放大工艺研究[J].药学研究,2018,37(8):466-468.
[13]徐华丽,陶志强,曾媛,等.盐酸溴己新吸入粉雾剂的质量与稳定性考察[J].中国药师,2018,21(6):1002-1006.
[14]王诗鹭,乔楚,刘桐.天麻超微粉胶囊的制备工艺研究[J].中国中医药现代远程教育,2018,16(16):75-77.
[15]国家药典委员会.中华人民共和国药典[M].北京:中国医药科技出版社,2015:951.
[16]程晓荟,吴瑶瑶,赵延慧,等.雌雄全蝎中蛋白质及多糖含量的测定与比较[J].山东农业科学,2016,48(3):130-132.