代谢性炎症与动脉粥样硬化内生热毒病机探讨
|
摘要
当前,深入研究动脉粥样硬化病理机制,积极探索动脉粥样硬化新的防治方法具有重大意义。随着人们生活习惯、饮食结构的改变,动脉粥样硬化的实证、热证越来越多,动脉粥样硬化内生热毒病机也越来越受到关注,而与此同时,现代医学则提出动脉粥样硬化的发生发展过程的实质是一种代谢性炎症。本文认为动脉粥样硬化毒邪病机说中,内生热毒是内生毒邪最常见的存在方式,动脉粥样硬化内生热毒病机与代谢性炎症密切相关,代谢性炎症是中医动脉粥样硬化内生热毒的致病机制之一。本文结合现代科学,从代谢性炎症角度探讨中医动脉粥样硬化内生热毒病机,阐释中医抽象病机概念的现代科学内涵,为清热解毒法防治动脉粥样硬化的临床及基础研究带来启发意义。
It is of great significance to study pathological mechanism and new treatment of atherosclerosis in recent days.With the living habits and dietary structure changed, excessive heat syndrome of atherosclerosis is increasing and endogenous hot poison mechanism is getting more and more attention. At the same time, modern medicine proposes the metabolic inflammation process of atherosclerosis. This paper believes that endogenous heat toxicity is the most common form of endogenous poison,endogenous heat toxicity pathogenesis of atherosclerosis is closely related to metabolic inflammation. Metabolic inflammation is one of the pathogenic mechanisms of endogenous heat toxicity. Combining with modern science, this paper explores endogenous heat toxicity pathogenesis from the perspective of metabolic inflammation, and explains the modern scientific connotation of abstract pathogenesis in traditional Chinese medicine, which brings inspiring meaning for the clinical and basic research of atherosclerosis detoxification method.
It is of great significance to study pathological mechanism and new treatment of atherosclerosis in recent days.With the living habits and dietary structure changed, excessive heat syndrome of atherosclerosis is increasing and endogenous hot poison mechanism is getting more and more attention. At the same time, modern medicine proposes the metabolic inflammation process of atherosclerosis. This paper believes that endogenous heat toxicity is the most common form of endogenous poison,endogenous heat toxicity pathogenesis of atherosclerosis is closely related to metabolic inflammation. Metabolic inflammation is one of the pathogenic mechanisms of endogenous heat toxicity. Combining with modern science, this paper explores endogenous heat toxicity pathogenesis from the perspective of metabolic inflammation, and explains the modern scientific connotation of abstract pathogenesis in traditional Chinese medicine, which brings inspiring meaning for the clinical and basic research of atherosclerosis detoxification method.
引文
[1] Kavurma MM,Rayner KJ,Karunakaran D. The walkingdead:macrophage inflammation and death in atherosclerosis[J]. Curr Opin Lipidol,2017,28(2):91-98.
[2]付聪,张娟.毒邪在糖尿病动脉粥样硬化中的发病机制及临床治疗[J].湖南中医杂志,2013,29(2):113.
[3]李国强,胡业彬.毒邪致动脉粥样硬化的病因病机探讨[J].河南中医,2010,30(12):1155-1156.
[4]刘美之,郎艳松,张鑫月,等.从痰、瘀、毒论治动脉粥样硬化研究进展[J].中医杂志,2014,55(9):800-803.
[5]黎汝楣,胡仁明.代谢性炎症综合征发病机制的研究进展[J].复旦学报:医学版,2017,44(3):380-384.
[6]高妍,陈守强,陈德智.丁书文运用热毒理论治疗高脂血症临证经验[J].亚太传统医药,2016,12(16):98-99.
[7]丁书文,李晓,李运伦,等.心系疾病中的热毒学说[J].中国医药学报,2004,19(10):592-594.
[8]丁书文,李晓,李运伦.热毒学说在心系疾病中的构建与应用[J].山东中医药大学学报,2004,28(6):413-416.
[9]王小玲,张军平,许颖智.论毒邪理论在心系疾病中的运用[J].中华中医药杂志,2012,27(8):2090-2093.
[10]孙朝润.中医学对“毒”的认识[J].中医研究,2011,24(9):1-3.
[11]王辉,郭利平,姜民,等.浅析从毒论治动脉粥样硬化[J].时珍国医国药,2008,19(9):2305-2306.
[12]苏祥飞,戴敏.动脉粥样硬化从毒论治述评[J].安徽中医学院学报,2013,33(2):1-4.
[13]岳仁宋,王丹,廖秋双,等.“足生大丁”与“糖尿病足”相关性探要[J].实用中医内科杂志,2011,25(3):62-63.
[14]李华,卢吴柱,程林,等.饮食习惯对高血压患者动脉粥样硬化的影响[J].分子影像学杂志,2018,41(2):264-267.
[15]王姗姗.清热解毒中药干预动脉粥样硬化的研究进展[J].中西医结合心脑血管病杂志,2017,15(8):935-938.
[16]胡仁明,谢颖,鹿斌,等. 2型糖尿病患者高发“代谢性炎症综合征”[J].中华内分泌代谢杂志,2016,32(1):27-32.
[17] Caesar R,Fak F,Backhed F. Effects of gut microbiota onobesity and atherosclerosis via modulation of inflammationand lipid metabolism[J]. J Intern Med,2010,268(4):320-328.
[18] Li F,Duan K,Wang C,et al.Probiotics and alcoholic liverdisease:treatment and potential mechanisms[J]. Gastroen-terol Res Pract,2016(2016):5491465.
[19] Chistiakov DA,Bobryshev YV,Kozarov E,et al. Role ofgut microbiota in the modulation of atherosclerosis-associ-ated immune response[J]. Front Microbiol,2015,47(6):671.
[20]晨星,郑清莲.解毒通络法防治动脉粥样硬化[J].中国中医药信息杂志,2009(S1):79-80.
[2]付聪,张娟.毒邪在糖尿病动脉粥样硬化中的发病机制及临床治疗[J].湖南中医杂志,2013,29(2):113.
[3]李国强,胡业彬.毒邪致动脉粥样硬化的病因病机探讨[J].河南中医,2010,30(12):1155-1156.
[4]刘美之,郎艳松,张鑫月,等.从痰、瘀、毒论治动脉粥样硬化研究进展[J].中医杂志,2014,55(9):800-803.
[5]黎汝楣,胡仁明.代谢性炎症综合征发病机制的研究进展[J].复旦学报:医学版,2017,44(3):380-384.
[6]高妍,陈守强,陈德智.丁书文运用热毒理论治疗高脂血症临证经验[J].亚太传统医药,2016,12(16):98-99.
[7]丁书文,李晓,李运伦,等.心系疾病中的热毒学说[J].中国医药学报,2004,19(10):592-594.
[8]丁书文,李晓,李运伦.热毒学说在心系疾病中的构建与应用[J].山东中医药大学学报,2004,28(6):413-416.
[9]王小玲,张军平,许颖智.论毒邪理论在心系疾病中的运用[J].中华中医药杂志,2012,27(8):2090-2093.
[10]孙朝润.中医学对“毒”的认识[J].中医研究,2011,24(9):1-3.
[11]王辉,郭利平,姜民,等.浅析从毒论治动脉粥样硬化[J].时珍国医国药,2008,19(9):2305-2306.
[12]苏祥飞,戴敏.动脉粥样硬化从毒论治述评[J].安徽中医学院学报,2013,33(2):1-4.
[13]岳仁宋,王丹,廖秋双,等.“足生大丁”与“糖尿病足”相关性探要[J].实用中医内科杂志,2011,25(3):62-63.
[14]李华,卢吴柱,程林,等.饮食习惯对高血压患者动脉粥样硬化的影响[J].分子影像学杂志,2018,41(2):264-267.
[15]王姗姗.清热解毒中药干预动脉粥样硬化的研究进展[J].中西医结合心脑血管病杂志,2017,15(8):935-938.
[16]胡仁明,谢颖,鹿斌,等. 2型糖尿病患者高发“代谢性炎症综合征”[J].中华内分泌代谢杂志,2016,32(1):27-32.
[17] Caesar R,Fak F,Backhed F. Effects of gut microbiota onobesity and atherosclerosis via modulation of inflammationand lipid metabolism[J]. J Intern Med,2010,268(4):320-328.
[18] Li F,Duan K,Wang C,et al.Probiotics and alcoholic liverdisease:treatment and potential mechanisms[J]. Gastroen-terol Res Pract,2016(2016):5491465.
[19] Chistiakov DA,Bobryshev YV,Kozarov E,et al. Role ofgut microbiota in the modulation of atherosclerosis-associ-ated immune response[J]. Front Microbiol,2015,47(6):671.
[20]晨星,郑清莲.解毒通络法防治动脉粥样硬化[J].中国中医药信息杂志,2009(S1):79-80.