2008-2017年河南省平顶山市手足口病流行病学和病原谱特征
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摘要
目的分析平顶山市2008-2017年手足口病(HFMD)的流行特征和病原谱。方法利用中国疾病预防控制信息管理系统收集平顶山市2008-2017年HFMD发病和病原学数据,进行描述性流行病学分析。结果平顶山市2008-2017年共报告HFMD 47 999例,年平均发病率为105.02/10万;≤5岁儿童病例占97.58%;4-6月份报告病例占55.00%;新华区、湛河区和卫东区3个主城区病例占42.49%。在2 903例实验室确诊病例中,肠道病毒71型(EV71)、柯萨奇病毒A16型(CV-A16)、其他肠道病毒感染分别占54.01%、17.05%、28.94%;在1 269例实验室确诊的重症病例中分别占74.94%、6.38%、18.68%。结论平顶山市HFMD发病呈现明显的年龄、季节和地区分布特征,以EV71和其他肠道病毒感染为主。需重点加强主城区、≤5岁儿童的HFMD防控和肠道病毒分型检测。
Objective To determine epidemiological characteristics and pathogen spectrum of hand, foot, and mouth disease(HFMD) in Pingdingshan city of Henan province during 2008-2017. Methods We collected HFMD case and etiological data in Pingdingshan during 2008-2017 as reported to the National Notifiable Disease Reporting System for a descriptive epidemiological analysis. Results A total of 47 999 HFMD cases were reported in Pingdingshan during2008-2017, for an average incidence of 105.02 per 100 000 population. 97.58% of cases were ≤5-year-old children,55.00% of cases were reported f rom April to June, and 42.49% of cases were reported by three urban districts-Xinhua, Zhanhe, and Weidong. Infections with enterovirus type 71(EV71), Coxsackie virus type A16(CV-A16), and other enteroviruses accounted for 54.01%, 17.05%, and 28.94% of 2 903 lab-confirmed cases, respectively, and 74.94%,6.38%, and 18.68% of 1 269 lab-confirmed severe cases. Conclusions The HFMD incidence showed clear characteristics in population, season, and region, with predominant infections with EV71 and other enteroviruses. We should focus on HFMD control and enterovirus detection for ≤5-year-old children and in central urban areas.
Objective To determine epidemiological characteristics and pathogen spectrum of hand, foot, and mouth disease(HFMD) in Pingdingshan city of Henan province during 2008-2017. Methods We collected HFMD case and etiological data in Pingdingshan during 2008-2017 as reported to the National Notifiable Disease Reporting System for a descriptive epidemiological analysis. Results A total of 47 999 HFMD cases were reported in Pingdingshan during2008-2017, for an average incidence of 105.02 per 100 000 population. 97.58% of cases were ≤5-year-old children,55.00% of cases were reported f rom April to June, and 42.49% of cases were reported by three urban districts-Xinhua, Zhanhe, and Weidong. Infections with enterovirus type 71(EV71), Coxsackie virus type A16(CV-A16), and other enteroviruses accounted for 54.01%, 17.05%, and 28.94% of 2 903 lab-confirmed cases, respectively, and 74.94%,6.38%, and 18.68% of 1 269 lab-confirmed severe cases. Conclusions The HFMD incidence showed clear characteristics in population, season, and region, with predominant infections with EV71 and other enteroviruses. We should focus on HFMD control and enterovirus detection for ≤5-year-old children and in central urban areas.
引文
[1] World Health Organization. Hand, foot and mouth disease(HFMD)[EB/OL].(2017-07-10)[2018-11-15]. http://www.wpro.who.int/china/mediacentre/factsheets/hfmd/en/.
[2] ZHUANG ZC, KOU ZQ, BAI YJ, et al. Epidemiological research on hand, foot, and mouth disease in mainland China[J]. Viruses, 2015, 7(12):6400-6411.
[3]中华人民共和国国家卫生和计划生育委员会.手足口病预防控制指南(2014版)[S]. 2014.National Health and Family Planning Commission of the People’ Republic of China. Guidelines for the prevention and control of hand-foot-mouth disease(2014)[S]. 2014.
[4]赵奇,朱俊萍.中国手足口病的流行状况及病原谱变化分析[J].病毒学报, 2015, 31(5):554-559.ZHAO Qi, ZHU Junping. Prevalence and analyses of the changing etiology of hand, foot and mouth disease in China[J]. Chinese Journal of Virology, 2015, 31(5):554-559.
[5]陈炜,翁育伟,何文祥,等. 2011~2013年福建省手足口病相关病原柯萨奇病毒A组6型的分子流行病学研究[J].病毒学报, 2014, 30(6):624-629.CHEN Wei, WENG Yuwei, HE Wenxiang, et al.Molecular epidemiology of HFMD-associated pathogen Coxsackievirus A6 in Fujian province,2011-2013[J].Chinese Journal of Virology, 2014, 30(6):624-629.
[6] HE S, CHEN M, WU W. An emerging and expanding clade accounts for the persistent outbreak of Coxsackievirus A6-associated hand, foot, and mouth disease in China since2013[J]. Virology, 2018, 518(5):328-334.
[7] ZENG H, LU J, YANG F, et al. The increasing epidemic of hand, foot, and mouth disease caused by Coxsackievirus-A6, Guangdong, China, 2017[J]. Journal of Infection, 2018, 76(2):220.
[8]张进,史永林,吴家兵,等.安徽省2008-2012年手足口病流行病学及病原学特征分析[J].中华疾病控制杂志, 2014,18(6):497-500.ZHANG Jin, SHI Yonglin, WU Jiabing, et al.Epidemiology and etiology of hand-foot-mouth disease in Anhui province, 2008-2012[J]. Chinese Journal of Disease Control&Prevention, 2014, 18(6):497-500.
[9] XING W, LIAO Q, VIBOUD C, et al. Hand, foot, and mouth disease in China, 2008–12:an epidemiological study[J]. The Lancet Infectious Diseases, 2014, 14(4):308-318.
[10] HUANG X, WEI H, WU S, et al. Epidemiological and etiological characteristics of hand, foot, and mouth disease in Henan, China, 2008-2013[J]. Scientific Reports, 2015,5(4):8904.
[11]曹洋,刘莹莹,于秋丽,等. 2010-2015年河北省手足口病流行特征分析[J].疾病监测, 2017, 32(1):29-33.CAO Yang, LIU Yingying, YU Qiuli, et al. Epidemiology of hand foot and mouth disease in Hebei, 2010-2015[J].Disease Surveillance, 2017, 32(1):29-33.
[12]陈国平,史永林,张进,等. 2008-2014年安徽省手足口病流行特征分析[J].现代预防医学, 2016, 43(4):588-590+630.CHEN Guoping, SHI Yonglin, ZHANG Jin, et al. Analysis of the epidemiological characteristics of hand-foot and-mouth disease in Anhui province between 2008 and2014[J]. Modern Preventive Medicine, 2016, 43(4):588-590+630.
[13]胡跃华,肖革新,郭莹,等. 2008-2011年中国大陆手足口病流行特征分析[J].中华疾病控制杂志, 2014, 18(8):693-697+747.HU Yuehua, XIAO Gexin, GUO Ying, et al. The epidemic features of the hand, foot, and mouth disease during 2008-2011 in China[J]. Chinese Journal of Disease Control&Prevention, 2014, 18(8):693-697+747.
[14]中国疾病预防控制中心.肠道病毒71型灭活疫苗使用技术指南[J].中国疫苗和免疫, 2016, 22(4):458-464.Chinese Center for Disease Control and Prevention.Technical guidelines for the use of inactivated enterovirus 71 vaccines[J]. Chinese Journal of Vaccines and Immunization, 2016(4):458-464.
[15] YANG Q, DING J, CAO J, et al. Epidemiological and etiological characteristics of hand, foot, and mouth disease in Wuhan, China from 2012 to 2013:outbreaks of Coxsackieviruses A10[J]. Journal of Medical Virology,2015, 87(6):954-960.
[2] ZHUANG ZC, KOU ZQ, BAI YJ, et al. Epidemiological research on hand, foot, and mouth disease in mainland China[J]. Viruses, 2015, 7(12):6400-6411.
[3]中华人民共和国国家卫生和计划生育委员会.手足口病预防控制指南(2014版)[S]. 2014.National Health and Family Planning Commission of the People’ Republic of China. Guidelines for the prevention and control of hand-foot-mouth disease(2014)[S]. 2014.
[4]赵奇,朱俊萍.中国手足口病的流行状况及病原谱变化分析[J].病毒学报, 2015, 31(5):554-559.ZHAO Qi, ZHU Junping. Prevalence and analyses of the changing etiology of hand, foot and mouth disease in China[J]. Chinese Journal of Virology, 2015, 31(5):554-559.
[5]陈炜,翁育伟,何文祥,等. 2011~2013年福建省手足口病相关病原柯萨奇病毒A组6型的分子流行病学研究[J].病毒学报, 2014, 30(6):624-629.CHEN Wei, WENG Yuwei, HE Wenxiang, et al.Molecular epidemiology of HFMD-associated pathogen Coxsackievirus A6 in Fujian province,2011-2013[J].Chinese Journal of Virology, 2014, 30(6):624-629.
[6] HE S, CHEN M, WU W. An emerging and expanding clade accounts for the persistent outbreak of Coxsackievirus A6-associated hand, foot, and mouth disease in China since2013[J]. Virology, 2018, 518(5):328-334.
[7] ZENG H, LU J, YANG F, et al. The increasing epidemic of hand, foot, and mouth disease caused by Coxsackievirus-A6, Guangdong, China, 2017[J]. Journal of Infection, 2018, 76(2):220.
[8]张进,史永林,吴家兵,等.安徽省2008-2012年手足口病流行病学及病原学特征分析[J].中华疾病控制杂志, 2014,18(6):497-500.ZHANG Jin, SHI Yonglin, WU Jiabing, et al.Epidemiology and etiology of hand-foot-mouth disease in Anhui province, 2008-2012[J]. Chinese Journal of Disease Control&Prevention, 2014, 18(6):497-500.
[9] XING W, LIAO Q, VIBOUD C, et al. Hand, foot, and mouth disease in China, 2008–12:an epidemiological study[J]. The Lancet Infectious Diseases, 2014, 14(4):308-318.
[10] HUANG X, WEI H, WU S, et al. Epidemiological and etiological characteristics of hand, foot, and mouth disease in Henan, China, 2008-2013[J]. Scientific Reports, 2015,5(4):8904.
[11]曹洋,刘莹莹,于秋丽,等. 2010-2015年河北省手足口病流行特征分析[J].疾病监测, 2017, 32(1):29-33.CAO Yang, LIU Yingying, YU Qiuli, et al. Epidemiology of hand foot and mouth disease in Hebei, 2010-2015[J].Disease Surveillance, 2017, 32(1):29-33.
[12]陈国平,史永林,张进,等. 2008-2014年安徽省手足口病流行特征分析[J].现代预防医学, 2016, 43(4):588-590+630.CHEN Guoping, SHI Yonglin, ZHANG Jin, et al. Analysis of the epidemiological characteristics of hand-foot and-mouth disease in Anhui province between 2008 and2014[J]. Modern Preventive Medicine, 2016, 43(4):588-590+630.
[13]胡跃华,肖革新,郭莹,等. 2008-2011年中国大陆手足口病流行特征分析[J].中华疾病控制杂志, 2014, 18(8):693-697+747.HU Yuehua, XIAO Gexin, GUO Ying, et al. The epidemic features of the hand, foot, and mouth disease during 2008-2011 in China[J]. Chinese Journal of Disease Control&Prevention, 2014, 18(8):693-697+747.
[14]中国疾病预防控制中心.肠道病毒71型灭活疫苗使用技术指南[J].中国疫苗和免疫, 2016, 22(4):458-464.Chinese Center for Disease Control and Prevention.Technical guidelines for the use of inactivated enterovirus 71 vaccines[J]. Chinese Journal of Vaccines and Immunization, 2016(4):458-464.
[15] YANG Q, DING J, CAO J, et al. Epidemiological and etiological characteristics of hand, foot, and mouth disease in Wuhan, China from 2012 to 2013:outbreaks of Coxsackieviruses A10[J]. Journal of Medical Virology,2015, 87(6):954-960.