桥本甲状腺炎自身抗体与血浆骨膜素水平的相关性分析
摘要
目的:检测桥本甲状腺炎患者血浆骨膜素(Periostin)水平,探讨其与甲状腺球蛋白抗体(TgAb)、甲状腺过氧化物酶抗体(TPOAb)之间的相关性。方法:选取重庆医科大学附属第二医院内分泌科就诊的桥本甲状腺炎患者47名作为桥本组,另选取医院体检中心体检健康者31名作为健康对照组(对照组),采用ELISA试剂盒检测血浆骨膜素水平,电化学发光免疫法测定血浆TgAb、TPOAb、TSH、FT3、FT4水平,统计并分析骨膜素水平与临床指标间的相关性。结果:桥本组和对照组骨膜素水平差异有统计学意义(P=0.005,P<0.05),桥本组血浆骨膜素水平高于对照组;骨膜素与TgAb、TPOAb呈正相关,与FT3呈负相关,与性别有相关性,与年龄、BMI、TSH、FT4无相关性,多元回归分析发现TPOAb是血浆骨膜素水平的独立相关因素。结论:骨膜素可能参与桥本甲状腺炎的免疫应答,与桥本甲状腺炎的发生与发展存在相互联系并影响TPOAb的水平。
引文
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[4]姜雨薇,马明瑶,张超,等.桥本甲状腺炎患者血清IL-35水平及相关性研究[J].湖北民族学院学报(医学版),2018(04).
[5]Idolazzi L,et al,Periostin:The bone and beyond,Eur J Intern Med(2016),http://dx.doi.org/10.1016/j.ejim.2016.11.015.
[6]Yanhua Bai,Yaqiong Li,Takashi Ozaki,et al,Ichiro Mori1 and Kennichi Kakudo:novel Isoforms of periostin expressed in the Human Thyroid,Japanese Clinical Medicine 2010:1 13-20 doi:10.4137/JCM.S5899.
[7]Liu,A.Y.,etal.,Periostin,a multifunctional matricellular protein in inflammatory and tumor microenvironments,Matrix Biol.(2014),http://dx.doi.org/10.1016/j.matbio.2014.04.007.
[8]Conway SJ,Izuhara K,Kudo Y,Litvin J,Markwald R,Ouyang G,Arron JR,Holweg CT,Kudo A(2014)The role of periostin in tissue remodeling across health and disease.Cell Mol Life Sci 71:1279-1288.doi:10.1007/s00018-013-1494-y
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[10]高青,潘苏华,等,桥本甲状腺炎病因病机与临床治疗研究进展[J].中国中药杂志,2012,37(20).
[11]谢永双,覃伟武,彭盛梅,等.桥本甲状腺炎患者血清TNF-α和IL-4水平的研究[J].上海交通大学学报(医学版),2009,29(10):1269-1271.