探讨新辅助化学治疗联合手术治疗局部晚期乳腺癌的疗效
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摘要
目的研究分析治疗局部晚期乳腺癌采用新辅助化学治疗联合手术治疗的效果。方法于2010年4月—2013年4月期间,择取我院收治的局部晚期乳腺癌患者100例,患者经双色球随机模式均分为两组,包括对照组和观察组各50例,对照组患者接受改良根治术治疗,观察组在手术前加用新辅助化学治疗,观察比较两组治疗情况。结果组间在临床疗效上比较,观察组比对照组总有效率显著更高(P<0.05);组间在肿瘤转移率及复发率上比较,观察组转移率及复发率均显著低于对照组(P<0.05);组间在术后生存率上比较,观察组术后1年、3年及5年生存率均比对照组明显更高(P<0.05)。结论临床治疗局部晚期乳腺癌采用新辅助化学治疗联合手术治疗能够促进疗效提升,降低肿瘤转移率、复发率,延长生存时间,值得推广。
Objective To study and analyze the effect of new adjuvant chemotherapy in the treatment of locally advanced breast cancer. MethodsFrom April 2010 to April 2013, 100 patients with locally advanced breast cancer patients were selected in our hospital, were treated by Shuangseqiu randomly divided into two groups, control group and observation group of 50 cases, control group patients received modified radical mastectomy, observation group before surgery combined with neoadjuvant chemotherapy, the treatment of the two groups were compared. ResultsComparison between groups in clinical efficacy, the total effective rate of the observation group was significantly higher than the control group(P﹤0.05); Compared tumor metastasis rate and recurrence rate, metastasis rate and recurrence rate of the observation group were significantly lower than the control group(P﹤0.05); among two groups in postoperative survival rate relatively, the observation group after 1 year, 3 years and 5 years survival rates were significantly higher than the control group(P﹤0.05). Conclusion Neoadjuvant chemotherapy combined with surgical treatment for locally advanced breast cancer can improve curative effect, reduce tumor metastasis rate, recurrence rate and prolong survival time, so it is worth promoting.
Objective To study and analyze the effect of new adjuvant chemotherapy in the treatment of locally advanced breast cancer. MethodsFrom April 2010 to April 2013, 100 patients with locally advanced breast cancer patients were selected in our hospital, were treated by Shuangseqiu randomly divided into two groups, control group and observation group of 50 cases, control group patients received modified radical mastectomy, observation group before surgery combined with neoadjuvant chemotherapy, the treatment of the two groups were compared. ResultsComparison between groups in clinical efficacy, the total effective rate of the observation group was significantly higher than the control group(P﹤0.05); Compared tumor metastasis rate and recurrence rate, metastasis rate and recurrence rate of the observation group were significantly lower than the control group(P﹤0.05); among two groups in postoperative survival rate relatively, the observation group after 1 year, 3 years and 5 years survival rates were significantly higher than the control group(P﹤0.05). Conclusion Neoadjuvant chemotherapy combined with surgical treatment for locally advanced breast cancer can improve curative effect, reduce tumor metastasis rate, recurrence rate and prolong survival time, so it is worth promoting.
引文
[1]曹志宇,何建苗,杨波,等.局部晚期乳腺癌新辅助化疗联合保乳手术的临床疗效观察:附81例报告[J].解放军医学杂志,2015,40(6):488-491.
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[3]张婧娴,刘玉娥,唐文恒,等.局部晚期乳腺癌术前介入治疗与全身化疗的对比研究[J].介入放射学杂志,2013,22(7):587-590.
[4]黄仁峰,雷睿文,欧林洋,等.局部晚期乳腺癌的新辅助化疗联合手术治疗的疗效观察[J].当代医学,2017,23(33):109-110.
[5]张青松,霍彦平,李茹捧,等.新辅助化疗联合保乳手术治疗老年局部晚期乳腺癌的临床分析[J].中国社区医师,2014,21(24):38-39.
[6]武海军,周瀛,石印青,等.新辅助化疗联合保乳手术在中晚期乳腺癌中临床疗效的分析[J].中国普通外科杂志,2013,22(11):1388-1392.
[7]高勇,张春梅,李治国,等.新辅助化疗与术后辅助化疗在局部晚期乳腺癌治疗中的临床观察[J].辽宁医学院学报,2015,36(5):47-48,66.
[8]张夕凉,姜福亭,田磊,等.新辅助化疗配合手术治疗中晚期乳腺癌的临床效果分析[J].现代生物医学进展,2014,14(21):4092-4094,4149.
[9]薛毅,康伟明.局部晚期乳腺癌患者TAC方案新辅助化疗的临床疗效及预后的影响[J].山西医药杂志,2017,46(3):336-338.
[10]牛四明,罗欢欢.新辅助化学治疗联合手术治疗局部晚期乳腺癌疗效观察[J].新乡医学院学报,2017,34(5):429-431.
[11]丁海霞,皮柯,周大明,等.新辅助化疗在中晚期乳腺癌保乳手术治疗中的作用及临床疗效[J].养生保健指南,2016,24(46):19.
[12]倪健彬,王颖.新辅助化疗联合保乳手术治疗中晚期乳腺癌的临床应用价值[J].临床心身疾病杂志,2016,22(z2):56.
[2]张培,张薇,齐晓敏,等.新辅助化疗的术式对局部晚期乳腺癌患者预后的影响[J].中华肿瘤防治杂志,2017,24(9):621-625.
[3]张婧娴,刘玉娥,唐文恒,等.局部晚期乳腺癌术前介入治疗与全身化疗的对比研究[J].介入放射学杂志,2013,22(7):587-590.
[4]黄仁峰,雷睿文,欧林洋,等.局部晚期乳腺癌的新辅助化疗联合手术治疗的疗效观察[J].当代医学,2017,23(33):109-110.
[5]张青松,霍彦平,李茹捧,等.新辅助化疗联合保乳手术治疗老年局部晚期乳腺癌的临床分析[J].中国社区医师,2014,21(24):38-39.
[6]武海军,周瀛,石印青,等.新辅助化疗联合保乳手术在中晚期乳腺癌中临床疗效的分析[J].中国普通外科杂志,2013,22(11):1388-1392.
[7]高勇,张春梅,李治国,等.新辅助化疗与术后辅助化疗在局部晚期乳腺癌治疗中的临床观察[J].辽宁医学院学报,2015,36(5):47-48,66.
[8]张夕凉,姜福亭,田磊,等.新辅助化疗配合手术治疗中晚期乳腺癌的临床效果分析[J].现代生物医学进展,2014,14(21):4092-4094,4149.
[9]薛毅,康伟明.局部晚期乳腺癌患者TAC方案新辅助化疗的临床疗效及预后的影响[J].山西医药杂志,2017,46(3):336-338.
[10]牛四明,罗欢欢.新辅助化学治疗联合手术治疗局部晚期乳腺癌疗效观察[J].新乡医学院学报,2017,34(5):429-431.
[11]丁海霞,皮柯,周大明,等.新辅助化疗在中晚期乳腺癌保乳手术治疗中的作用及临床疗效[J].养生保健指南,2016,24(46):19.
[12]倪健彬,王颖.新辅助化疗联合保乳手术治疗中晚期乳腺癌的临床应用价值[J].临床心身疾病杂志,2016,22(z2):56.