新辅助化疗联合外科手术应用于局部晚期乳腺癌治疗的效果研究
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摘要
目的探讨局部晚期乳腺癌采取新辅助化疗联合外科手术治疗的效果。方法 58例局部晚期乳腺癌患者,根据入组奇偶顺序分为观察组与对照组,各29例。对照组患者采取根治术治疗,观察组患者先实施新辅助化疗2~3周期后2周内开展外科手术治疗,两组患者术后均予以常规化疗手段,比较两组患者临床效果。结果观察组患者临床总有效率为79.31%,明显高于对照组的58.62%,差异有统计学意义(P<0.05)。观察组患者术后肿瘤复发率与转移率明显低于对照组,观察组随访1年生存率明显高于对照组,差异均有统计学意义(P<0.05)。结论局部晚期乳腺癌采取外科手术治疗切实可行,若能联合新辅助化疗处理后再实施手术治疗可改善预后,值得借鉴。
Objective To investigate the effect of neoadjuvant chemotherapy combined with surgical therapy for locally advanced breast cancer. Methods A total of 58 patients with locally advanced breast cancer were divided into observation group and control group according to the parity order of the group, 29 cases in each group. Patients in the control group were treated with radical resection, patients in the observation group were treated with neoadjuvant chemotherapy for 2 to 3 cycles at first, followed by surgical treatment within 2 weeks. Patients of two groups were given conventional chemotherapy after surgery, and the clinical effects of two groups were compared. Results The total clinical effective rate of the observation group was 79.31%, which was significantly higher than 58.62% of the control group, the difference was statistically significant(P<0.05). The postoperative tumor recurrence rate and metastasis rate of the observation group were significantly lower than those of the control group, and the 1 year survival rate of followed up in the observation group was significantly higher than that in the control group, the differences were statistically significant(P<0.05). Conclusion Surgical therapy for locally advanced breast cancer is feasible. If the implementation of surgical therapy after combined with neoadjuvant chemotherapy can improve the prognosis, it is worth learning.
Objective To investigate the effect of neoadjuvant chemotherapy combined with surgical therapy for locally advanced breast cancer. Methods A total of 58 patients with locally advanced breast cancer were divided into observation group and control group according to the parity order of the group, 29 cases in each group. Patients in the control group were treated with radical resection, patients in the observation group were treated with neoadjuvant chemotherapy for 2 to 3 cycles at first, followed by surgical treatment within 2 weeks. Patients of two groups were given conventional chemotherapy after surgery, and the clinical effects of two groups were compared. Results The total clinical effective rate of the observation group was 79.31%, which was significantly higher than 58.62% of the control group, the difference was statistically significant(P<0.05). The postoperative tumor recurrence rate and metastasis rate of the observation group were significantly lower than those of the control group, and the 1 year survival rate of followed up in the observation group was significantly higher than that in the control group, the differences were statistically significant(P<0.05). Conclusion Surgical therapy for locally advanced breast cancer is feasible. If the implementation of surgical therapy after combined with neoadjuvant chemotherapy can improve the prognosis, it is worth learning.
引文
[1]刘正人,聊识君,王晓娇,等.外科手术在7例局部晚期乳腺癌治疗中的价值探讨.上海医药,2015,26(13):13-15.
[2]黄仁峰,雷睿文,欧林洋,等.局部晚期乳腺癌的新辅助化疗联合手术治疗的疗效观察.当代医学,2017,23(33):109-110.
[3]牛四明,罗欢欢.新辅助化学治疗联合手术治疗局部晚期乳腺癌疗效观察.新乡医学院学报,2017,34(5):429-431.
[4]龚益平.外科手术在晚期乳腺癌中的作用与地位.医学与哲学,2014,13(18):6-7.
[5]孙强,周易冬,黄汉源,等.新辅助治疗在局部晚期乳腺癌中的应用.中国肿瘤临床,2003,30(4):283-285.
[6]田延锋,赵增仁,李勇.局部晚期乳腺癌保乳治疗的研究进展.中国普通外科杂志,2012,21(5):582-586.
[7]张婧娴,刘玉娥,唐文恒.局部晚期乳腺癌术前介入治疗与全身化疗的对比研究.介入放射学杂志,2013,22(7):587-590.
[8]李子庆,凌华海.局部晚期乳腺癌序贯治疗中全身性新辅助化疗联合局部化疗的临床分析.中华肿瘤防治杂志,2006,13(17):1358.
[9]赵荫农,陈建思.局部晚期乳腺癌介入治疗后的手术切除研究.广西医学,2000,22(2):244-246.
[10]林燕,孙强,管珩,等.老年乳腺癌的手术方式选择.中国医学科学院学报,2012,34(6):605-608.
[2]黄仁峰,雷睿文,欧林洋,等.局部晚期乳腺癌的新辅助化疗联合手术治疗的疗效观察.当代医学,2017,23(33):109-110.
[3]牛四明,罗欢欢.新辅助化学治疗联合手术治疗局部晚期乳腺癌疗效观察.新乡医学院学报,2017,34(5):429-431.
[4]龚益平.外科手术在晚期乳腺癌中的作用与地位.医学与哲学,2014,13(18):6-7.
[5]孙强,周易冬,黄汉源,等.新辅助治疗在局部晚期乳腺癌中的应用.中国肿瘤临床,2003,30(4):283-285.
[6]田延锋,赵增仁,李勇.局部晚期乳腺癌保乳治疗的研究进展.中国普通外科杂志,2012,21(5):582-586.
[7]张婧娴,刘玉娥,唐文恒.局部晚期乳腺癌术前介入治疗与全身化疗的对比研究.介入放射学杂志,2013,22(7):587-590.
[8]李子庆,凌华海.局部晚期乳腺癌序贯治疗中全身性新辅助化疗联合局部化疗的临床分析.中华肿瘤防治杂志,2006,13(17):1358.
[9]赵荫农,陈建思.局部晚期乳腺癌介入治疗后的手术切除研究.广西医学,2000,22(2):244-246.
[10]林燕,孙强,管珩,等.老年乳腺癌的手术方式选择.中国医学科学院学报,2012,34(6):605-608.