miRNA及其相关SNP在非小细胞肺癌预后中作用的研究概况
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摘要
原发性肺癌是迄今为止恶性程度最高的肿瘤之一,而病发的患者中约有85%是非小细胞肺癌(NSCLC)。因此,找到NSCLC的发病机制,确定有效的治疗方案并改善预后状况,对于降低病发率就显得尤为重要。本文对近些年与NSCLC预后相关的miRNA-SNP的作用机制以及常用研究方法做了归纳总结,为确定NSCLC的有效分子标记物,改善患者术后病情和降低复发死亡率提供了理论依据。
Primary lung cancer is one of the most malignant tumors so far, and about 85% of the patients with this disease are non-small cell lung cancer(NSCLC). Therefore, finding the pathogenesis of NSCLC, determining effective treatment and improving prognosis are particularly important for reducing the incidence of NSCLC. In this paper, we summarized the mechanism and common research methods of microRNAs-SNPs related to the prognosis of NSCLC in recent years, which provided a theoretical basis for identifying effective molecular markers of NSCLC, improving the patient's condition and reducing recurrence mortality.
Primary lung cancer is one of the most malignant tumors so far, and about 85% of the patients with this disease are non-small cell lung cancer(NSCLC). Therefore, finding the pathogenesis of NSCLC, determining effective treatment and improving prognosis are particularly important for reducing the incidence of NSCLC. In this paper, we summarized the mechanism and common research methods of microRNAs-SNPs related to the prognosis of NSCLC in recent years, which provided a theoretical basis for identifying effective molecular markers of NSCLC, improving the patient's condition and reducing recurrence mortality.
引文
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[2]赫羽喆.人,鼠microRNA靶点结合结构及保守性研究[D].吉林大学,2013.
[3]Orom UA,Nielsen FC,Lund AH.MicroRNA10a binds the 5’UTR of ribosomal protein m R NAs and enhances their translation[J].Mol Cell,2008,30(4):460471.
[4]Place RF,Li LC,Pookot D,et al.Micro R NA373 induces expression of genes with complementary promoter sequences[J].Proc Natl Acad Sci USA,2008,105(5):16081613.
[5]Tay Y,Zhang J,Thomson AM,et al.Micro R NAs to nanog,Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation[J].Nature,2008,455(7216):11241128.
[6]金吉春,金星林.microRNA的概述及其研究[J].医学研究生学报,2013,26(10):1109-1112.
[7]王明阳,王光磊,陈新亮,张燚,龙淼.MicroRNA的生物学功能及其与肿瘤诊断和治疗的研究进展[J].动物医学进展,2018,39(01):95-98.
[8]李琼,王阁.MicroRNA在肿瘤发生机制中的研究进展[J].肿瘤学杂志,2007(06):493-495.
[9]陈熹,张峻峰,曾科,张辰宇.血清microRNA--一种非侵入性的肿瘤标志物[J].生命科学,2010,22(07):649-654.
[10]李敬华,王萍玉.microRNA及SNP在非小细胞肺癌治疗和预后中的作用[J].滨州医学院学报,2016,39(04):285-288.
[11]洪超,李盈甫,马千里,等.CDH13基因变异与非小细胞肺癌的相关性[J].昆明医科大学学报,2016,37(6):48-51.
[12]Li Y,Yao Y,Qian X,et al.The Association of Adiponectin Gene Promoter Variations with Non-Small Cell Lung Cancer in a Han Chinese population[J].PloS One,2015,10(5):e0127751.
[13]郭旭.肿瘤代谢相关基因单核苷酸多态性与非小细胞肺癌预后相关性研究及其机制[D].西安:第四军医大学,2015.
[14]李雪莲.MiRNA遗传变异与肺腺癌易感性及预后关系的研究[D].沈阳:中国医科大学,2014.