兰索拉唑联合胃苏颗粒治疗慢性胃炎的临床疗效和安全性
|
摘要
目的探讨兰索拉唑联合胃苏颗粒治疗慢性胃炎的临床疗效和安全性。方法选取2017年8月至2018年5月我院收治的慢性胃炎患者120例,随机分为干预组(采用兰索拉唑联合胃苏颗粒治疗, 60例)和常规组(采用兰索拉唑治疗, 60例),比较两组的临床疗效及不良反应发生率。结果干预组的总有效率为98.33%,显著高于常规组的86.67%(P <0.05)。两组患者的头晕、腹泻、皮疹、肝肾功损伤发生率比较无统计学差异(P>0.05)。结论兰索拉唑联合胃苏颗粒治疗慢性胃炎患者具有显著的疗效和较高的用药安全性。
Objective To explore the clinical efficacy and safety of lansoprazole combined with Weisu granules in the treatment of chronic gastritis. Methods 120 cases of patients with chronic gastritis admitted to our hospital from August 2017 to May 2018 were selected and randomly divided into intervention group(lansoprazole combined with Weisu granules, 60 cases) and routine group(lansoprazole, 60 cases). The clinical efficacy and incidence of adverse reactions were compared between the two groups. Results The total effective rate of the intervention group was 98.33%, significantly higher than 86.67% of the routine group(P <0.05). No statistical difference was found in the incidences of dizziness, diarrhea, rash and liver and kidney function injury between the two groups(P >0.05). Conclusions Lansoprazole combined with Weisu granules has significant efficacy and higher safety in the treatment of patients with chronic gastritis.
Objective To explore the clinical efficacy and safety of lansoprazole combined with Weisu granules in the treatment of chronic gastritis. Methods 120 cases of patients with chronic gastritis admitted to our hospital from August 2017 to May 2018 were selected and randomly divided into intervention group(lansoprazole combined with Weisu granules, 60 cases) and routine group(lansoprazole, 60 cases). The clinical efficacy and incidence of adverse reactions were compared between the two groups. Results The total effective rate of the intervention group was 98.33%, significantly higher than 86.67% of the routine group(P <0.05). No statistical difference was found in the incidences of dizziness, diarrhea, rash and liver and kidney function injury between the two groups(P >0.05). Conclusions Lansoprazole combined with Weisu granules has significant efficacy and higher safety in the treatment of patients with chronic gastritis.
引文
[1]陈新,王安平.胃苏颗粒辅助治疗对慢性胃炎患者胃黏膜环氧化酶-2、钙黏蛋白E表达及血清降钙素原、胃泌素水平的影响[J].海南医学院学报, 2018, 24(1):19-22.
[2]邓媛,王奇.胃苏颗粒对慢性胃炎患者血清炎症因子及胃黏膜COX-2、 E-cadherin表达的影响[J].中国中医药科技, 2016, 23(5):518-520.
[3]刘志清,艾耀伟.胃苏颗粒联合三联疗法对慢性胃炎患者血清炎症因子的影响[J].湖北中医药大学学报, 2017, 19(4):24-27.
[4]严学义.养胃颗粒联合三联疗法对慢性胃炎伴Hp感染的疗效观察[J].浙江临床医学, 2015, 17(11):1967-1968.
[5]陶海燕,陆燕,黄晓宇.荆花胃康胶丸治疗HP阳性慢性胃炎临床观察[J].陕西中医, 2017, 38(2):159-160.
[6] Mohamed HR. Estimation of TiO2nanoparticle-induced genotoxicity persistence and possible chronic gastritis-induction in mice[J]. Food Chem Toxicol, 2015, 83:76-83.
[7]曲智威,于明俊,刘春雷.半夏泻心汤治疗幽门螺杆菌阳性相关性胃炎98例临床研究[J].北华大学学报(自然科学版), 2017, 18(3):368-370.
[8]贾宝洋,杨志平,关晓辉.金胃泰胶囊治疗慢性胃炎胃十二指肠溃疡的临床效果[J].中国老年学杂志, 2016, 36(5):1148-1149.
[9] Yoshida T, Kato J, Inoue I, et al. Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer[J]. Int J Cancer, 2014, 134(6):1445-1457.
[10]刘思珠,陈天艳.半夏泻心汤与三联疗法联用治疗幽门螺杆菌感染慢性胃炎的临床效果分析[J].现代消化及介入诊疗, 2017, 22(4):516-518.
[11] McLeland SM, Lunn KF, Duncan CG, et al. Relationship among serum creatinine, serum gastrin, calcium-phosphorus product, and uremic gastropathy in cats with chronic kidney disease[J]. J Vet Intern Med, 2014, 28(3):827-837.
[12] Polydorides AD. Pathology and differential diagnosis of chronic, noninfectious gastritis[J]. Semin Diagn Pathol, 2014, 31(2):114-123.
[2]邓媛,王奇.胃苏颗粒对慢性胃炎患者血清炎症因子及胃黏膜COX-2、 E-cadherin表达的影响[J].中国中医药科技, 2016, 23(5):518-520.
[3]刘志清,艾耀伟.胃苏颗粒联合三联疗法对慢性胃炎患者血清炎症因子的影响[J].湖北中医药大学学报, 2017, 19(4):24-27.
[4]严学义.养胃颗粒联合三联疗法对慢性胃炎伴Hp感染的疗效观察[J].浙江临床医学, 2015, 17(11):1967-1968.
[5]陶海燕,陆燕,黄晓宇.荆花胃康胶丸治疗HP阳性慢性胃炎临床观察[J].陕西中医, 2017, 38(2):159-160.
[6] Mohamed HR. Estimation of TiO2nanoparticle-induced genotoxicity persistence and possible chronic gastritis-induction in mice[J]. Food Chem Toxicol, 2015, 83:76-83.
[7]曲智威,于明俊,刘春雷.半夏泻心汤治疗幽门螺杆菌阳性相关性胃炎98例临床研究[J].北华大学学报(自然科学版), 2017, 18(3):368-370.
[8]贾宝洋,杨志平,关晓辉.金胃泰胶囊治疗慢性胃炎胃十二指肠溃疡的临床效果[J].中国老年学杂志, 2016, 36(5):1148-1149.
[9] Yoshida T, Kato J, Inoue I, et al. Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer[J]. Int J Cancer, 2014, 134(6):1445-1457.
[10]刘思珠,陈天艳.半夏泻心汤与三联疗法联用治疗幽门螺杆菌感染慢性胃炎的临床效果分析[J].现代消化及介入诊疗, 2017, 22(4):516-518.
[11] McLeland SM, Lunn KF, Duncan CG, et al. Relationship among serum creatinine, serum gastrin, calcium-phosphorus product, and uremic gastropathy in cats with chronic kidney disease[J]. J Vet Intern Med, 2014, 28(3):827-837.
[12] Polydorides AD. Pathology and differential diagnosis of chronic, noninfectious gastritis[J]. Semin Diagn Pathol, 2014, 31(2):114-123.