传统沙生蒙药沙芥的化学成分研究
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摘要
[目的]对沙芥的化学成分进行系统研究,为蒙药的研发提供扎实的物质基础,促进沙产业发展。[方法]利用多种色谱法,如正相硅胶、反相ODS、Sephadex LH-20及高效液相色谱等进行分离纯化,并通过理化性质及波谱分析鉴定化合物结构。[结果]从沙芥70%乙醇提取物中分离鉴定了7个单体化合物,分别为β-谷甾醇(1)、胡萝卜素(2)、staphylionoside D(3)、TgSSTg(4)、乙基-α-D-果糖苷(5)、pinellic acid(6)、Z-咖啡酸硬脂醇酯(7)。[结论]化合物3～7为首次从该属植物中分离得到。
[Objective] The paper is aim to study the constituents from P. cornutum systematically,and promote the development of sand industry and construct the green economy in China. [Methods] The chemical compounds were isolated through kinds of chromatorgraphies such as Sephadex LH-20,ODS,Silica gel and PHPLC chromatorgraphies and identified by chemical and spectral analysis(1 H,13 C NMR,1 H 1 H COSY,HMQC,HMBC,UV,IR,MS).[Results] Seven compounds were obtained and identified as β-sitosterol(1) daucosterol(2),staphylionoside D(3),TgSSTg(4) ethyl-α-D-fructofuranoside(5) pinellic acid(6) Z-octadecyl caffeate(7) respectively. [Conclusion] Compounds 3-7 were obtained from Pugionium genus firstly.
[Objective] The paper is aim to study the constituents from P. cornutum systematically,and promote the development of sand industry and construct the green economy in China. [Methods] The chemical compounds were isolated through kinds of chromatorgraphies such as Sephadex LH-20,ODS,Silica gel and PHPLC chromatorgraphies and identified by chemical and spectral analysis(1 H,13 C NMR,1 H 1 H COSY,HMQC,HMBC,UV,IR,MS).[Results] Seven compounds were obtained and identified as β-sitosterol(1) daucosterol(2),staphylionoside D(3),TgSSTg(4) ethyl-α-D-fructofuranoside(5) pinellic acid(6) Z-octadecyl caffeate(7) respectively. [Conclusion] Compounds 3-7 were obtained from Pugionium genus firstly.
引文
[1] Li H,Li C,Zhang C,et al. Compositional and gastrointestinal prokinetic studies of Pugionium(L.)[J]. Food Chem,2015,(186):285-291.
[2]江苏新医学院.中药大辞典[M].上海:上海人民出版社,1977:1162.
[3]加建斌,刘晓英.沙芥的价值及开发与利用[J].安徽农学通报,2007,13(14):82-83.
[4]瞿璐,刘艳霞,李建良,等.祁菊叶化学成分的分离与结构鉴定[J].天津中医药大学学报,2017,36(1):57-60.
[5]董勇喆,史文中,杨圣财,等.沙葱化学成分的分离与结构鉴定[J].天津中医药大学学报,2016,35(6):404-408.
[6]刘丽丽,李晓霞,陈玥,等,槐米化学成分研究I[J].天津中医药大学学报,2014,33(4):230-233.
[7]刘丽丽,李晓霞,陈玥,等,槐米中酚酸类化学成分研究I[J].天津中医药大学学报,2014,33(1):39-41.
[8]施天一,廖志新,叶润,等.塔黄的化学成分研究[J].西北药学杂志,2014,29(6):571-573.
[9] Yu Q,Matsunami K,Otsuka H,et al. Staphylionosides AK:megastigmane glucosides from the leaves of Staphylea bumalda DC[J]. Chem Pharm Bull,2005,53(7):800-807.
[10] Shaw CF,Eldridge J,Cancro MP. 13C NMR studies of aurothioglucose:ligand exchange and redox disproportionation reactions[J]. J Inorg Biochem,1981,14(3):267-274.
[11]黄娟娟,胡长鹰,潘慧芳.番木瓜中糖类成分的纯化与鉴定[J].食品科学,2011,32(13):89-151.
[12] Hong SS,Oh JS. Inhibitors of antigen-induced degranulation of RBL-2H3 cells isolated from Wheat Bran[J]. J Korean Soc Appl Biol Chem,2012,55(1):69-74.
[13]孟凡成,王磊,张健,等.云南黄连中非生物碱类化学成分的研究[J].中国药科大学学报,2013,44(4):307-310.
[2]江苏新医学院.中药大辞典[M].上海:上海人民出版社,1977:1162.
[3]加建斌,刘晓英.沙芥的价值及开发与利用[J].安徽农学通报,2007,13(14):82-83.
[4]瞿璐,刘艳霞,李建良,等.祁菊叶化学成分的分离与结构鉴定[J].天津中医药大学学报,2017,36(1):57-60.
[5]董勇喆,史文中,杨圣财,等.沙葱化学成分的分离与结构鉴定[J].天津中医药大学学报,2016,35(6):404-408.
[6]刘丽丽,李晓霞,陈玥,等,槐米化学成分研究I[J].天津中医药大学学报,2014,33(4):230-233.
[7]刘丽丽,李晓霞,陈玥,等,槐米中酚酸类化学成分研究I[J].天津中医药大学学报,2014,33(1):39-41.
[8]施天一,廖志新,叶润,等.塔黄的化学成分研究[J].西北药学杂志,2014,29(6):571-573.
[9] Yu Q,Matsunami K,Otsuka H,et al. Staphylionosides AK:megastigmane glucosides from the leaves of Staphylea bumalda DC[J]. Chem Pharm Bull,2005,53(7):800-807.
[10] Shaw CF,Eldridge J,Cancro MP. 13C NMR studies of aurothioglucose:ligand exchange and redox disproportionation reactions[J]. J Inorg Biochem,1981,14(3):267-274.
[11]黄娟娟,胡长鹰,潘慧芳.番木瓜中糖类成分的纯化与鉴定[J].食品科学,2011,32(13):89-151.
[12] Hong SS,Oh JS. Inhibitors of antigen-induced degranulation of RBL-2H3 cells isolated from Wheat Bran[J]. J Korean Soc Appl Biol Chem,2012,55(1):69-74.
[13]孟凡成,王磊,张健,等.云南黄连中非生物碱类化学成分的研究[J].中国药科大学学报,2013,44(4):307-310.