丁苯酞对急性脑梗死患者脑血流参数与氧自由基清除能力的影响
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摘要
目的:探究丁苯酞对急性脑梗死患者脑血流参数与氧自由基清除能力的影响。方法:将2016年12月～2017年10月期间本院收治的66例急性脑梗死患者根据随机数字表法分为对照组33例和观察组33例,对照组进行常规急性脑梗死治疗,观察组则在对照组治疗的基础上加用丁苯酞,然后检测与比较两组患者治疗前后的脑血流参数与氧自由基清除能力指标。结果:治疗前两组患者的脑血流参数与氧自由基清除能力指标差异无统计学意义(P>0.05),而治疗后1周与2周两组的脑血流参数与氧自由基清除能力指标均持续改善,且观察组的检测结果优于对照组同时间的结果(P<0.05)。结论:丁苯酞对急性脑梗死患者的脑血流参数与氧自由基清除能力具有改善作用,因此在患者脑部血供改善与损伤修复中具有更高的应用价值。
Objective:To investigate the influence of butylphthalide for the cerebral blood flow parameters and oxygen free radical scavenging activity of patients with acute cerebral infarction.Methods:66 patients with acute cerebral infarction in our hospital from December 2016 to October 2017 were divided into control group of 33 cases and observation group of 33 cases using tables of random numbers.The control group was treated with conventional treatment of acute cerebral infarction,and the observation group were treated with butylphthalide on the treatment of control group,then the cerebral blood flow parameters and oxygen free radical scavenging activity indexes of two groups before and after the treatment were detected and compared.Results:The cerebral blood flow parameters and oxygen free radical scavenging activity indexes of two groups before the treatment had no significant differences(P>0.05),and the cerebral blood flow parameters and oxygen free radical scavenging activity indexes of two groups at the first and second week after the treatment were improved continuously,and the detection results of observation group were better than those of control group at the same time(P <0.05).Conclusion:The butylphthalide plays the role of improving the cerebral blood flow parameters and oxygen free radical scavenging activity of patients with acute cerebral infarction,so it has higher application value for the improvement of brain blood supply and repair of injury.
Objective:To investigate the influence of butylphthalide for the cerebral blood flow parameters and oxygen free radical scavenging activity of patients with acute cerebral infarction.Methods:66 patients with acute cerebral infarction in our hospital from December 2016 to October 2017 were divided into control group of 33 cases and observation group of 33 cases using tables of random numbers.The control group was treated with conventional treatment of acute cerebral infarction,and the observation group were treated with butylphthalide on the treatment of control group,then the cerebral blood flow parameters and oxygen free radical scavenging activity indexes of two groups before and after the treatment were detected and compared.Results:The cerebral blood flow parameters and oxygen free radical scavenging activity indexes of two groups before the treatment had no significant differences(P>0.05),and the cerebral blood flow parameters and oxygen free radical scavenging activity indexes of two groups at the first and second week after the treatment were improved continuously,and the detection results of observation group were better than those of control group at the same time(P <0.05).Conclusion:The butylphthalide plays the role of improving the cerebral blood flow parameters and oxygen free radical scavenging activity of patients with acute cerebral infarction,so it has higher application value for the improvement of brain blood supply and repair of injury.
引文
1顾浩,赵变歌,李世学,等.丁苯酞软胶囊对急性脑梗死患者神经功能缺损及日常生活活动能力恢复的影响[J].中国实用神经疾病杂志,2016,19(5):116-117.
2 黄旭玲.丁苯酞氯化钠注射液联合低分子肝素钙治疗急性进展性脑梗死的疗效分析[J].中国卫生标准管理,2015,6(28):123-124.
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4 张格娟,田晔,狄政利,等.丁苯酞注射液对急性脑梗死患者神经功能及脑血流量的影响[J].卒中与神经疾病,2015,21(5):302-304.
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6 张丽丽.丁苯酞注射液对急性脑梗死患者神经功能及脑血管储备能力的影响[J].基层医学论坛,2016,20(33):4658-4659.
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8 谢昊霖,王莉梅,韩铭,等.丁苯酞注射液对急性缺血性脑梗死患者神经功能影响的Meta分析[J].中国新药与临床杂志,2016,35(7):492-498.
9 赵景茹,李娜,董立朋,等.丁苯酞氯化钠注射液对急性脑梗死患者血流变相关指标的影响[J].河北医药,2016,38(19):2997-2998.
10 Hu Q,Liang X,Chen D,et al.Delayed hyperbaric oxygen therapy promotes neurogenesis through reactive oxygen species/hypoxia-inducible factor-1α/β-catenin pathway in middle cerebral artery occlusion rats[J].Stroke,2014,45(6):1807-1814.
11 李平,汪波.依达拉奉联合溶栓治疗急性脑梗死的疗效及对氧自由基清除效果的影响[J].中国现代医学杂志,2015,25(28):49-52.
12 宋学萍,于士龙,祝淑贞,等.BiPAP干预急性脑梗死合并OSAHS患者血浆中NO、氧自由基表达的变化及意义[J].中国老年学杂志,2015,35(9):2399-2402.
13 蒋娟莉,张建.急性脑梗死介入治疗后应用丁苯酞联合依达拉奉改善神经功能恢复的临床研究[J].海南医学院学报,2016,22(16):1884-1886.
14 陆婉杏,罗章伟,蒙兰青.尤瑞克林针联合中药对首发急性脑梗死局部脑血流影响[J].辽宁中医药大学学报,2016,18(1):154-156.
15 李龙珠,刘家军,张梅,等.丹参酮ⅡA磺酸钠联合依达拉奉对脑梗死局部脑血流及血液流变学影响[J].辽宁中医药大学学报,2016,18(2):182-184.
2 黄旭玲.丁苯酞氯化钠注射液联合低分子肝素钙治疗急性进展性脑梗死的疗效分析[J].中国卫生标准管理,2015,6(28):123-124.
3 葛晓航,刘乐喜,赵秀秀.丁苯酞对急性脑梗死患者神经功能及脑血管储备能力的影响[J].中国实用神经疾病杂志,2016,19(3):109-110.
4 张格娟,田晔,狄政利,等.丁苯酞注射液对急性脑梗死患者神经功能及脑血流量的影响[J].卒中与神经疾病,2015,21(5):302-304.
5 孔起良,刘娟,杨震,等.早期使用丁苯酞注射液治疗基底节区脑梗死对侧支循环建立及神经功能的影响[J].临床神经病学杂志,2016,29(4):293-295.
6 张丽丽.丁苯酞注射液对急性脑梗死患者神经功能及脑血管储备能力的影响[J].基层医学论坛,2016,20(33):4658-4659.
7 Garrigue P,Giacomino L,Bucci C,et al.Single photon emission computed tomography imaging of cerebral blood flow,bloodbrain barrier disruption,and apoptosis time course after focal cerebral ischemia in rats[J].Int J Stroke,2016,11(1):117-126.
8 谢昊霖,王莉梅,韩铭,等.丁苯酞注射液对急性缺血性脑梗死患者神经功能影响的Meta分析[J].中国新药与临床杂志,2016,35(7):492-498.
9 赵景茹,李娜,董立朋,等.丁苯酞氯化钠注射液对急性脑梗死患者血流变相关指标的影响[J].河北医药,2016,38(19):2997-2998.
10 Hu Q,Liang X,Chen D,et al.Delayed hyperbaric oxygen therapy promotes neurogenesis through reactive oxygen species/hypoxia-inducible factor-1α/β-catenin pathway in middle cerebral artery occlusion rats[J].Stroke,2014,45(6):1807-1814.
11 李平,汪波.依达拉奉联合溶栓治疗急性脑梗死的疗效及对氧自由基清除效果的影响[J].中国现代医学杂志,2015,25(28):49-52.
12 宋学萍,于士龙,祝淑贞,等.BiPAP干预急性脑梗死合并OSAHS患者血浆中NO、氧自由基表达的变化及意义[J].中国老年学杂志,2015,35(9):2399-2402.
13 蒋娟莉,张建.急性脑梗死介入治疗后应用丁苯酞联合依达拉奉改善神经功能恢复的临床研究[J].海南医学院学报,2016,22(16):1884-1886.
14 陆婉杏,罗章伟,蒙兰青.尤瑞克林针联合中药对首发急性脑梗死局部脑血流影响[J].辽宁中医药大学学报,2016,18(1):154-156.
15 李龙珠,刘家军,张梅,等.丹参酮ⅡA磺酸钠联合依达拉奉对脑梗死局部脑血流及血液流变学影响[J].辽宁中医药大学学报,2016,18(2):182-184.