补气益血汤联合小剂量铁剂治疗缺铁性贫血疗效及预后分析
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摘要
目的:探究补气益血汤联合小剂量铁剂对缺铁性贫血的治疗效果。方法:选取2014年10月—2017年10月间在我院治疗的84例缺铁性贫血患者进行研究。按照随机数表法,将其随机均分为观察组和对照组各42例,对照组患者采用常规小剂量铁剂对患者进行治疗,观察组在对照组的基础上联合使用补血益气汤对患者进行治疗。治疗9周后,对两组患者西医临床疗效和中医症候疗效进行分析,记录两组患者治疗前后红细胞(RBC)、血清铁蛋白(SF)、血红蛋白(HGB)、平均红细胞体积(MCV)和红细胞平均血红蛋白浓度(MCHC)变化,比较两组患者治疗过程中呕吐、腹泻等不良事件的发生情况。结果:观察组患者的西医临床疗效有效率(95.23%)显著高于对照组(78.57%),中医症候疗效有效率(97.61%)明显高于对照组(83.34%),比较以上各组数据,差异有统计学意义(P<0.05);观察组患者治疗期间不良事件的发生率(9.52%)明显低于对照组(30.95%),差异有统计学意义(P<0.05);治疗后观察组患者的RBC含量、SF含量、HGB含量、MCV值和MCHC值均高于对照组,差异有统计学意义(P<0.05)。结论:采用补气益血汤联合小剂量铁剂对缺铁性贫血进行治疗,能够明显提高患者的临床治疗有效率和康复速度,降低治疗过程中不良情况的发生,改善患者的生活质量。
Objective:To explore the therapeutic effect of Buqi Yixue Decoction combined with low dose iron on iron deficiency anemia. Methods:84 cases from October 2014 to October 2017 in our hospital treatment of iron deficiency anemia patients,randomly divided into observation group and control group with 42 cases in each group,the control group was treated with conventional law dose iron in treatment of patients,the observation group combined use of Buqi Yixue Decoction based on control group in treatment of patients. After 9 weeks of treatment,the two groups of patients with clinical curative effect of Western medicine and TCM syndrome curative effect analysis,recorded the two groups before and after treatment of red blood cell(RBC),serum ferritin(SF),hemoglobin(HGB),mean corpuscular volume(MCV)and mean corpuscular hemoglobin concentration(MCHC)content changes. Occur vomiting,diarrhea and other adverse events were compared between the two groups in the process. Results:The clinical curative effect of observation group(92.35%)was significantly higher than the control group(78.57%),the curative effect of TCM syndrome in the observation group(97.61%)was significantly higher than the control group(83.34%),there were statistically significant differences between the two groups of data(P<0.05);the incidence of adverse events during treatment was significantly lower in the observation group(9.52%)than in the control group(30.95%),the difference was statistically significant(P<0.05);after treatment,the levels of SF,RBC content,HGB content,MCV content and MCHC values in the observation group were higer than those in the control group,the difference was statistically significant(P<0.05). Conclusion:Buqi Yixue Decoction combined with low dose iron on iron deficiency anemia treatment,can significantly improve the effective rate of clinical treatment and recovery rate,reduce the adverse situation in the course of treatment,improve the quality of life of patients.
Objective:To explore the therapeutic effect of Buqi Yixue Decoction combined with low dose iron on iron deficiency anemia. Methods:84 cases from October 2014 to October 2017 in our hospital treatment of iron deficiency anemia patients,randomly divided into observation group and control group with 42 cases in each group,the control group was treated with conventional law dose iron in treatment of patients,the observation group combined use of Buqi Yixue Decoction based on control group in treatment of patients. After 9 weeks of treatment,the two groups of patients with clinical curative effect of Western medicine and TCM syndrome curative effect analysis,recorded the two groups before and after treatment of red blood cell(RBC),serum ferritin(SF),hemoglobin(HGB),mean corpuscular volume(MCV)and mean corpuscular hemoglobin concentration(MCHC)content changes. Occur vomiting,diarrhea and other adverse events were compared between the two groups in the process. Results:The clinical curative effect of observation group(92.35%)was significantly higher than the control group(78.57%),the curative effect of TCM syndrome in the observation group(97.61%)was significantly higher than the control group(83.34%),there were statistically significant differences between the two groups of data(P<0.05);the incidence of adverse events during treatment was significantly lower in the observation group(9.52%)than in the control group(30.95%),the difference was statistically significant(P<0.05);after treatment,the levels of SF,RBC content,HGB content,MCV content and MCHC values in the observation group were higer than those in the control group,the difference was statistically significant(P<0.05). Conclusion:Buqi Yixue Decoction combined with low dose iron on iron deficiency anemia treatment,can significantly improve the effective rate of clinical treatment and recovery rate,reduce the adverse situation in the course of treatment,improve the quality of life of patients.
引文
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[5]刘玉静.健脾生血颗粒联合富马酸亚铁对缺铁性贫血患儿的改善效果[J].实用中西医结合临床,2017,17(12):35-37.
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[13]何然,汪宏锦,周莹,等.四物汤对幼鼠缺铁性贫血的改善及其对铁代谢的调节作用[J].中国中药杂志,2017,42(5):944-950.
[14]黄昭前,姚红霞,林丽娥,等.血常规检测对地中海贫血与缺铁性贫血患者感染的临床诊断分析[J].中华医院感染学杂志,2016,26(15):3447-3449.
[15]吴潍,李秋菊.归脾汤中药配方颗粒剂与传统饮片煎剂治疗女性缺铁性贫血临床疗效对比[J].中华中医药学刊,2016,34(3):750-753.
[16]周振环,郎立新,李君,等.乌梅消食颗粒对缺铁性贫血患者白细胞减少症的疗效观察[J].世界中西医结合杂志,2017,12(12):1731-1734.
[17]陈智,林圣云,周郁鸿,等. 220例慢性再生障碍性贫血中医症状和证型临床特点分析[J].中国中西医结合杂志,2014,34(1):43-45.
[18]何圆圆,曾丽红,庄远,等.重型β地中海贫血患者输注保存不同时间红细胞后血红蛋白浓度的变化[J].中国输血杂志,2015,28(11):1351-1354.
[19]贺远.多糖铁复合物治疗缺铁性贫血的疗效及对sTfR和SF含量的影响[J].中国生化药物杂志,2014,34(4):116-117,120.
[20]刘晓,白玉盛,江明,等.平均红细胞体积、红细胞体积分布宽度在非重型再生障碍性贫血早期疗效预测中的作用[J].重庆医学,2014,43(24):3170-3173.
[2]张飞虹,胡君华.琥珀酸亚铁治疗妊娠合并缺铁性贫血的疗效与安全性观察[J].中国药房,2015,26(24):3335-3337.
[3]薛春娥,沈庆慧,王艳,等.血清红细胞生成素水平在缺铁性贫血中的临床意义[J].中国实验血液学杂志,2015,23(5):1410-1414.
[4]杜春然.血液检验在贫血鉴别诊断中的应用价值[J].中国药物经济学,2017,12(12):140-142.
[5]刘玉静.健脾生血颗粒联合富马酸亚铁对缺铁性贫血患儿的改善效果[J].实用中西医结合临床,2017,17(12):35-37.
[6]张之南,沈悌.血液病诊断及疗效标准[M].北京:科学出版社,2007.
[7]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:69.
[8]杜丽,秦丹卿,兰菲菲,等.轻型β地中海贫血合并缺铁性贫血患者血红蛋白A_2水平的变化[J].广东医学,2016,37(13):1982-1984.
[9]李双月,裴仁治,陆滢,等.宁波市鄞州区学龄前儿童贫血状况及其影响因素的调查[J].现代实用医学,2017,29(12):1644-1645,1650.
[10]崔娜.12~14岁青春前期青少年学生的缺铁性贫血状况及其影响因素[J].中国医药指南,2017,15(34):60-61.
[11]Picone D,Re GL,Pappalardo S. Hamartoma of the spleen(splenoma)with calcifications in a child with beta-thalassemia:A case report[J].Giambelluca D,2017,11(5):7-12.
[12]旷满华,杨青廷,翦耀文,等.儿童缺铁性贫血与血铅水平关系的Meta分析[J].中华疾病控制杂志,2016,20(1):79-83.
[13]何然,汪宏锦,周莹,等.四物汤对幼鼠缺铁性贫血的改善及其对铁代谢的调节作用[J].中国中药杂志,2017,42(5):944-950.
[14]黄昭前,姚红霞,林丽娥,等.血常规检测对地中海贫血与缺铁性贫血患者感染的临床诊断分析[J].中华医院感染学杂志,2016,26(15):3447-3449.
[15]吴潍,李秋菊.归脾汤中药配方颗粒剂与传统饮片煎剂治疗女性缺铁性贫血临床疗效对比[J].中华中医药学刊,2016,34(3):750-753.
[16]周振环,郎立新,李君,等.乌梅消食颗粒对缺铁性贫血患者白细胞减少症的疗效观察[J].世界中西医结合杂志,2017,12(12):1731-1734.
[17]陈智,林圣云,周郁鸿,等. 220例慢性再生障碍性贫血中医症状和证型临床特点分析[J].中国中西医结合杂志,2014,34(1):43-45.
[18]何圆圆,曾丽红,庄远,等.重型β地中海贫血患者输注保存不同时间红细胞后血红蛋白浓度的变化[J].中国输血杂志,2015,28(11):1351-1354.
[19]贺远.多糖铁复合物治疗缺铁性贫血的疗效及对sTfR和SF含量的影响[J].中国生化药物杂志,2014,34(4):116-117,120.
[20]刘晓,白玉盛,江明,等.平均红细胞体积、红细胞体积分布宽度在非重型再生障碍性贫血早期疗效预测中的作用[J].重庆医学,2014,43(24):3170-3173.