复方消化酶胶囊联合益生菌制剂治疗小儿功能性消化不良的效果观察
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摘要
目的:探讨复方消化酶胶囊联合益生菌制剂治疗小儿功能性消化不良的效果。方法:收集2017年6月—2018年3月来我院接受治疗的50例患儿的临床资料。按照随机数字表法均分为观察组和对照组各25例。对照组:复方消化酶胶囊治疗。观察组:复方消化酶胶囊联合益生菌制剂双歧杆菌乳杆菌三联活菌片治疗。观察患儿症状改善时间、基本症状积分变化情况。结果:观察组症状改善时间低于对照组,差异显著(P<0.05),观察组干预后腹胀、胃脘痛、纳差少食、不易消化积分均低于干预前和对照组,差异显著(P<0.05)。观察组和对照组干预前餐后30min、餐后60min胃排空率对比,P>0.05;观察组和对照组干预后餐后30min、餐后60min胃排空率均高于干预前,差异显著(P<0.05);观察组干预后餐后60min胃排空率高于干预前和对照组,差异显著(P<0.05)。观察组和对照组干预前胃窦、胃底、小弯频率对比,P>0.05;观察组和对照组干预后餐后胃窦、胃底、小弯频率均高于干预前,差异显著(P<0.05);观察组和对照组干预后胃窦、胃底、小弯频率对比,P>0.05。结论:复方消化酶胶囊联合益生菌制剂治疗小儿功能性消化不良,能够快速改善患儿症状,改善患儿症状积分。
Objective:To investigate the effect of compound digestive enzyme capsule combined with probiotics on functional dyspepsia in children.Methods:50 children received treatment in our hospital from October 2017 to June 2018 were collected.According to the random number table method,they were equally divided into observation group and control group,with 25 cases in each group,the control group with compound digestive enzyme capsules treatment,and the observation group with compound digestive enzyme capsules combined with probiotics live combined Bi?dobacterium and Lactobacillus Tablets treatment.The improvement time of symptoms and the change of basic symptom scores were observed.Results:The improvement time of symptoms in the observation group was signi?cantly lower than that in the control group(P<0.05).The scores of abdominal distention,epigastralgia,poor appetite and indigestion in the observation group were signi?cantly lower than those before and after the intervention(P<0.05).The gastric emptying rate of observation group and control group at 30 minutes before and 60 minutes after meal was higher than that before meal(P<0.05);the gastric emptying rate of observation group and control group at 30 minutes after meal and 60 minutes after meal was higher than that before intervention(P<0.05);the gastric emptying rate of observation group at 60 minutes after meal was higher than that before intervention and control group(P<0.05).The frequencies of antrum,fundus and minor curvature in observation group and control group before intervention did not show any difference,P>0.05;the frequencies of antrum,fundus and minor curvature in observation group and control group after intervention were higher than those before intervention,the difference was signi?cant(P<0.05);the frequencies of antrum,fundus and minor curvature in observation group and control group after intervention did not show any difference,P>0.05.Conclusion:Compound Digestive Enzyme Capsule combined with probiotics in the treatment of children with functional dyspepsia can quickly improve the symptoms of children,improve the symptoms score of children with high application value.
Objective:To investigate the effect of compound digestive enzyme capsule combined with probiotics on functional dyspepsia in children.Methods:50 children received treatment in our hospital from October 2017 to June 2018 were collected.According to the random number table method,they were equally divided into observation group and control group,with 25 cases in each group,the control group with compound digestive enzyme capsules treatment,and the observation group with compound digestive enzyme capsules combined with probiotics live combined Bi?dobacterium and Lactobacillus Tablets treatment.The improvement time of symptoms and the change of basic symptom scores were observed.Results:The improvement time of symptoms in the observation group was signi?cantly lower than that in the control group(P<0.05).The scores of abdominal distention,epigastralgia,poor appetite and indigestion in the observation group were signi?cantly lower than those before and after the intervention(P<0.05).The gastric emptying rate of observation group and control group at 30 minutes before and 60 minutes after meal was higher than that before meal(P<0.05);the gastric emptying rate of observation group and control group at 30 minutes after meal and 60 minutes after meal was higher than that before intervention(P<0.05);the gastric emptying rate of observation group at 60 minutes after meal was higher than that before intervention and control group(P<0.05).The frequencies of antrum,fundus and minor curvature in observation group and control group before intervention did not show any difference,P>0.05;the frequencies of antrum,fundus and minor curvature in observation group and control group after intervention were higher than those before intervention,the difference was signi?cant(P<0.05);the frequencies of antrum,fundus and minor curvature in observation group and control group after intervention did not show any difference,P>0.05.Conclusion:Compound Digestive Enzyme Capsule combined with probiotics in the treatment of children with functional dyspepsia can quickly improve the symptoms of children,improve the symptoms score of children with high application value.
引文
[1]王小仙,陈啸洪,刘淑梅,等.小儿功能性消化不良的临床特征及治疗分析[J].中华全科医学,2014,12(04):591-593.
[2]唐莉,邵征洋.邵征洋教授运用调中饮治疗小儿功能性消化不良经验[J].中医儿科杂志,2018,14(03):17-18.
[3]潘慧,卢小蕴,吕小青.醒脾养儿颗粒联合双歧杆菌四联活菌片治疗小儿功能性消化不良及其对血清炎症因子影响[J].浙江中西医结合杂志,2018,28(02):126-128.
[4]于意,许春娣.儿童功能性消化不良研究现状及诊疗共识解读[J].现代实用医学,2014,26(11):1329-1331.
[5]陈捷,徐辉.乐食合剂为主治疗对小儿功能性消化不良胃电图节律的影响[J].中华中医药学刊,2009,27(06):1270-1271.
[6]Singh V,Singh M,Schurman JV,et al.Histopathological changes in the gastroduodenal mucosa of children with functional dyspepsia[J].Pathol Res Pract,2018,214(8):1173-1178.
[7]齐纪芳.小儿功能性消化不良的诊断和治疗现状[J].现代消化及介入诊疗,2015,20(05):557-559.
[8]王小仙,陈啸洪,刘淑梅,等.小儿功能性消化不良的临床特征及治疗分析[J].中华全科医学,2014,12(04):591-593.
[9]Ko SJ,Park JW,Lee JH,et al.Herbal medicine Yukgunja-tang for functional dyspepsia protocol for a systematic review of randomized controlled trials[J].Medicine(Baltimore),2018,97(40):12555.
[10]Addula M,Wilson VED,Reddymasu S,et al.Immunopathological and molecular basis of functional dyspepsia and current therapeutic approaches[J].Expert Rev Clin Immunol,2018,14(10):831-840.
[11]何小莉,刘健.雷尼替丁联合多潘立酮治疗小儿消化不良的临床疗效分析[J].当代医学,2017,23(15):115-117.
[12]Wauters L,Nightingale S,Jones M,et al.Letter:functional dyspepsia is associated with duodenal eosinophilia in an Australian paediatric cohortmethodological issues to avoid misinterpretation.Authors'reply[J].Aliment Pharmacol Ther,2017,46(3):388.
[13]孙燕燕.小儿功能性消化不良的药物治疗进展[J].儿科药学杂志,2013,19(04):60-64.
[14]杨丽萍.小儿功能性消化不良的临床诊断与治疗[J].当代医学,2011,17(08):50-51.
[15]邹月新.微生态制剂在儿科消化疾病治疗中的临床应用[J].临床医学研究与实践,2018,3(26):85-86.
[2]唐莉,邵征洋.邵征洋教授运用调中饮治疗小儿功能性消化不良经验[J].中医儿科杂志,2018,14(03):17-18.
[3]潘慧,卢小蕴,吕小青.醒脾养儿颗粒联合双歧杆菌四联活菌片治疗小儿功能性消化不良及其对血清炎症因子影响[J].浙江中西医结合杂志,2018,28(02):126-128.
[4]于意,许春娣.儿童功能性消化不良研究现状及诊疗共识解读[J].现代实用医学,2014,26(11):1329-1331.
[5]陈捷,徐辉.乐食合剂为主治疗对小儿功能性消化不良胃电图节律的影响[J].中华中医药学刊,2009,27(06):1270-1271.
[6]Singh V,Singh M,Schurman JV,et al.Histopathological changes in the gastroduodenal mucosa of children with functional dyspepsia[J].Pathol Res Pract,2018,214(8):1173-1178.
[7]齐纪芳.小儿功能性消化不良的诊断和治疗现状[J].现代消化及介入诊疗,2015,20(05):557-559.
[8]王小仙,陈啸洪,刘淑梅,等.小儿功能性消化不良的临床特征及治疗分析[J].中华全科医学,2014,12(04):591-593.
[9]Ko SJ,Park JW,Lee JH,et al.Herbal medicine Yukgunja-tang for functional dyspepsia protocol for a systematic review of randomized controlled trials[J].Medicine(Baltimore),2018,97(40):12555.
[10]Addula M,Wilson VED,Reddymasu S,et al.Immunopathological and molecular basis of functional dyspepsia and current therapeutic approaches[J].Expert Rev Clin Immunol,2018,14(10):831-840.
[11]何小莉,刘健.雷尼替丁联合多潘立酮治疗小儿消化不良的临床疗效分析[J].当代医学,2017,23(15):115-117.
[12]Wauters L,Nightingale S,Jones M,et al.Letter:functional dyspepsia is associated with duodenal eosinophilia in an Australian paediatric cohortmethodological issues to avoid misinterpretation.Authors'reply[J].Aliment Pharmacol Ther,2017,46(3):388.
[13]孙燕燕.小儿功能性消化不良的药物治疗进展[J].儿科药学杂志,2013,19(04):60-64.
[14]杨丽萍.小儿功能性消化不良的临床诊断与治疗[J].当代医学,2011,17(08):50-51.
[15]邹月新.微生态制剂在儿科消化疾病治疗中的临床应用[J].临床医学研究与实践,2018,3(26):85-86.