经络导平联合甲钴胺治疗糖尿病周围神经病变的临床效果
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摘要
目的观察经络导平联合甲钴胺治疗糖尿病周围神经病变的临床效果。方法选取2016年5月～2017年2月在中国中医科学院望京医院及北京市通州区永乐店社区卫生服务中心就诊的糖尿病周围神经病变门诊患者80例,采用随机数字表法随机分为治疗组和对照组,每组各40例。对照组予降糖、控制相关危险因素和口服甲钴胺等常规治疗,治疗组在常规治疗的基础上加用经络导平治疗,连续治疗8周。比较治疗前后两组患者临床症状、感觉及运动神经的传导速度变化以及血流变学指标水平。结果治疗组总有效率显著高于对照组,差异有统计学意义(P<0.05);两组腓总神经、正中神经的运动和感觉神经传导速度在治疗后均有升高,且治疗组显著高于对照组(P<0.05);两组全血高切黏度、全血中切黏度、全血低切黏度、血浆黏度均较治疗前下降(P<0.05);且治疗组各指标明显低于对照组(P<0.05)。结论经络导平联合甲钴胺治疗可缓解糖尿病神经病变患者的临床症状,提高感觉及运动神经的传导速度以及改善血流变学指标水平,具有很好的临床疗效。
Objective To investigate the clinical effect of meridian guide flat combined with Mecobalamin in the treatment of diabetic peripheral neuropathy. Methods Eighty patients with diabetic peripheral neuropathy admitted in Wangjing Hospital of Chinese Academy of Traditional Chinese Medicine and Yongledian Community Health Service Center of Tongzhou District in Beijing City from May 2016 to February 2017 were selected and they were divided into control group and treatment group according to random number table method, with 40 cases in each group. The control group was treated with Mecobalamin simply, while the treatment group was treated with Mecobalamin combined with meridian guide flat. The two groups were treated for 8 weeks. Clinical symptoms, conduction velocity of sensory and motor nerves, blood rheology were compared between the two groups before and after treatment. Results The total effective rate of treatment group was higher than that of control group, the difference was statistically significant(P < 0.05).Motor and sensory conduction velocity of common peroneal nerve and median nerve were higher after treatment in both groups, and treatment group was significantly higher than control group(P < 0.05). Whole blood high, medium, low shear viscosity and plasma viscosity declined after treatment in both groups(P < 0.05), and those in the treatment group were significantly lower than control group(P < 0.05).Conclusion Meridian guide flat combined with Mecobalamin can relieve symptoms of patients with diabetes peripheral neuropathy and improve conduction velocity of sensory and motor nerves, it also can improve blood rheology and have satisfied effect.
Objective To investigate the clinical effect of meridian guide flat combined with Mecobalamin in the treatment of diabetic peripheral neuropathy. Methods Eighty patients with diabetic peripheral neuropathy admitted in Wangjing Hospital of Chinese Academy of Traditional Chinese Medicine and Yongledian Community Health Service Center of Tongzhou District in Beijing City from May 2016 to February 2017 were selected and they were divided into control group and treatment group according to random number table method, with 40 cases in each group. The control group was treated with Mecobalamin simply, while the treatment group was treated with Mecobalamin combined with meridian guide flat. The two groups were treated for 8 weeks. Clinical symptoms, conduction velocity of sensory and motor nerves, blood rheology were compared between the two groups before and after treatment. Results The total effective rate of treatment group was higher than that of control group, the difference was statistically significant(P < 0.05).Motor and sensory conduction velocity of common peroneal nerve and median nerve were higher after treatment in both groups, and treatment group was significantly higher than control group(P < 0.05). Whole blood high, medium, low shear viscosity and plasma viscosity declined after treatment in both groups(P < 0.05), and those in the treatment group were significantly lower than control group(P < 0.05).Conclusion Meridian guide flat combined with Mecobalamin can relieve symptoms of patients with diabetes peripheral neuropathy and improve conduction velocity of sensory and motor nerves, it also can improve blood rheology and have satisfied effect.
引文
[1]王瑞阳,马文杰.糖尿病周围神经病变的中西医研究进展[J].中医临床研究,2016,8(3):89-90.
[2]王鸿庆,孙继飞,徐云生.糖尿病周围神经病变的中医研究进展[J].江苏中医药,2015,47(1):83-85.
[3]缪軻軻,葛静.中西医治疗糖尿病周围神经病变研究进展[J].河南中医,2017,37(4):742-743.
[4]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014(7):447-498.
[5]中华人民共和国中医药行业标准中医病证诊断疗效标准[M].北京:中国医药科技出版社,2012:38.
[6]方朝晖,吴以岭,赵进东.糖尿病周围神经病变中医临床诊疗指南(2016年版)[J].中医杂志,2017,58(7):625-630.
[7]郑筱萸.中药新药临床研究指导原则[M].北京.中国医药科技出版社,2002:233-237.
[8]杨秀颖,张莉,陈熙,等.2型糖尿病周围神经病变机制研究进展[J].中国药理学通报,2016,32(5):598-602.
[9]Callaghan BC,Cheng HT,Stables CL,et al.Diabetic neuropathy:clinical manifestations and current treatments[J].Lancet Neurol,2012,11(6):521-534.
[10]高宏艳.甲钴胺治疗糖尿病周围神经病变疗效观察[J].糖尿病新世界,2017,20(3):158-159.
[11]邢诗敏.甲钴胺注射液治疗糖尿病周围神经病变的研究[J].中国医药指南,2017,15(24):22-23.
[12]廖二元.内分泌代谢病学[M].3版.北京:人民卫生出版社,2012:1375.
[13]周仲英.中医内科学[M].北京:中国中医药出版社,2004:427,481,500.
[14]袁锡林.中西医结合治疗糖尿病周围神经病变概况[J].实用中医内科杂志,2016,30(12):118-121.
[15]任辉.针罐联合治疗糖尿病周围神经病变疗效观察[J].内蒙古中医药,2013,32(4):59-60.
[16]赵卫东.针刺联合经络导平治疗语言发育迟缓的临床研究[J].中国实用医药,2016,11(14):281-282.
[17]冯丽萍,李科信,苏国华,等.经络导平仪在脑卒中后偏瘫康复中的应用[J].中国中医急症,2014,23(7):1386-1387.
[18]王佩玲.针刺结合经络导平治疗儿童过敏性鼻炎临床疗效观察[J].中医临床研究,2016,8(3):100-101,106.
[19]庄伊洢,黄晓卿,陈玄,等.电刺激参数在电针疗法中的选用现状及存在问题[J].中医临床研究,2015,7(23):139-141.
[20]刘川.语言训练联合经络导平仪治疗语言发育迟缓的临床研究[J].中国社区医师,2017,33(3):81-82.
[2]王鸿庆,孙继飞,徐云生.糖尿病周围神经病变的中医研究进展[J].江苏中医药,2015,47(1):83-85.
[3]缪軻軻,葛静.中西医治疗糖尿病周围神经病变研究进展[J].河南中医,2017,37(4):742-743.
[4]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014(7):447-498.
[5]中华人民共和国中医药行业标准中医病证诊断疗效标准[M].北京:中国医药科技出版社,2012:38.
[6]方朝晖,吴以岭,赵进东.糖尿病周围神经病变中医临床诊疗指南(2016年版)[J].中医杂志,2017,58(7):625-630.
[7]郑筱萸.中药新药临床研究指导原则[M].北京.中国医药科技出版社,2002:233-237.
[8]杨秀颖,张莉,陈熙,等.2型糖尿病周围神经病变机制研究进展[J].中国药理学通报,2016,32(5):598-602.
[9]Callaghan BC,Cheng HT,Stables CL,et al.Diabetic neuropathy:clinical manifestations and current treatments[J].Lancet Neurol,2012,11(6):521-534.
[10]高宏艳.甲钴胺治疗糖尿病周围神经病变疗效观察[J].糖尿病新世界,2017,20(3):158-159.
[11]邢诗敏.甲钴胺注射液治疗糖尿病周围神经病变的研究[J].中国医药指南,2017,15(24):22-23.
[12]廖二元.内分泌代谢病学[M].3版.北京:人民卫生出版社,2012:1375.
[13]周仲英.中医内科学[M].北京:中国中医药出版社,2004:427,481,500.
[14]袁锡林.中西医结合治疗糖尿病周围神经病变概况[J].实用中医内科杂志,2016,30(12):118-121.
[15]任辉.针罐联合治疗糖尿病周围神经病变疗效观察[J].内蒙古中医药,2013,32(4):59-60.
[16]赵卫东.针刺联合经络导平治疗语言发育迟缓的临床研究[J].中国实用医药,2016,11(14):281-282.
[17]冯丽萍,李科信,苏国华,等.经络导平仪在脑卒中后偏瘫康复中的应用[J].中国中医急症,2014,23(7):1386-1387.
[18]王佩玲.针刺结合经络导平治疗儿童过敏性鼻炎临床疗效观察[J].中医临床研究,2016,8(3):100-101,106.
[19]庄伊洢,黄晓卿,陈玄,等.电刺激参数在电针疗法中的选用现状及存在问题[J].中医临床研究,2015,7(23):139-141.
[20]刘川.语言训练联合经络导平仪治疗语言发育迟缓的临床研究[J].中国社区医师,2017,33(3):81-82.