中药化学成分PK/PD研究进展
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摘要
PK/PD结合模型是研究药物时间-浓度、浓度-效应、时间-效应三者之间关系的有力工具,PK/PD研究对指导临床用药具有重要意义。中药成分复杂,其药效物质基础尚未完全明确,因此将PK/PD结合模型应用于中药研究,有利于阐明药效物质基础及作用机制,对中药及其制剂的开发研究具有指导性意义。本文通过查阅文献综述了近年来PK/PD结合模型在中药单体成分及有效部位、单味中药和中药复方中的应用,为今后中药化学成分PK/PD研究提供参考。
PK-PD binding model is a powerful tool to study the relationship between drug time-concentration,concentration-effect and time-effect, which is of great significance and widely used in guiding clinical medicine. The PK-PD binding model is applied to the study of traditional Chinese medicine(TCM), which is helpful to elucidate the basis of drug substance and its mechanism. It is of great significance to the development of TCM and its preparation. In this paper, recent applications of PK-PD binding model in the composition and effective part of TCM, single herbal medicine and TCM compound were made, which could provide references for future PK-PD study of chemical constituent.
PK-PD binding model is a powerful tool to study the relationship between drug time-concentration,concentration-effect and time-effect, which is of great significance and widely used in guiding clinical medicine. The PK-PD binding model is applied to the study of traditional Chinese medicine(TCM), which is helpful to elucidate the basis of drug substance and its mechanism. It is of great significance to the development of TCM and its preparation. In this paper, recent applications of PK-PD binding model in the composition and effective part of TCM, single herbal medicine and TCM compound were made, which could provide references for future PK-PD study of chemical constituent.
引文
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3 任欣怡,陈渊成,王琰,等.丹酚酸A对大鼠血浆中同型半胱氨酸调节作用的药动学-药效学结合模型.中国药科大学学报,2012,43(3):260-265.
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6 于宜平,张艳,李红,等.黄芩苷对角叉菜胶致热大鼠解热作用的PK-PD模型研究.中草药,2014,45(4):527-531.
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12 张泉龙.乌头碱经皮给药药代动力学和药效动力学结合研究.上海:第二军医大学硕士学位论文,2009.
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15 Shi S J,Chen H,Gu S F,et al.Pharmacokinetic-Pharmacodynamic modeling of daurisoline in beagle doges.Chin Hosp Pharm J,2003,23(12):713-714.
16 陈琼,冬雪川,师少军,等.蝙蝠葛苏林碱和蝙蝠葛碱犬体内药动学-药效学结合研究.中国药学杂志,2004,40(5):53-56.
17 Shi S J,Gu S F,Chen H,et al.Pharmacokinetic-Pharmacodynamic modeling of dauricine in beagle doges.China Pharmacological Bull,2005,21(4):464-467.
18 Yan T,Wang H,Zhao M,et al.Glycyrrhizin protects against acetaminophen-Induced acute liver injury via alleviating tumor necrosis factor amediated apoptosis.Drug Metab Dispos,2016,44(5):720-731.
19 王丽,胡樱凡,童东,等.黄连碱对内毒素发热大鼠解热作用的PKPD研究.中国药理学通报,2017,33(4):552-556.
20 黄芳,陈渊成,刘晓东.板蓝根总生物碱中表告依春在发热大鼠体内的药动学-药效学结合模型研究.中草药,2007,38(10):1514-1519.
21 田瑶.青藤碱关节腔局部PK-PD结合模型研究.广州:广州中医药大学硕士学位论文,2012.
22 邵继征,田瑶,周莉玲.利用微透析技术进行青藤碱治疗类风湿性关节炎药动-药效学考察.中国医院药学杂志,2013,33(19):1576-1580.
23 戴亮,郝海平,汪玉馨,等.松果菊苷药动/药效研究进展与思考.中国临床药理学与治疗学,2010,15(3):342-349.
24 杨永茂.大黄蒽醌保护肠粘膜屏障损伤的PK-PD结合模型研究.成都:成都中医药大学硕士学位论文,2011.
25 柳晓泉.丹参水溶性成份的多靶点心血管保护作用的PK-PD研究.第十届全国药物和化学异物代谢学术会议暨第三届国际ISSX/CSSX联合学术会议论文集,2015.
26 刘晓,汤道权,印晓星,等.银杏叶提取物含药血清在大鼠体内药动学与药效学相关性研究.徐州医学院学报,2009,29(8):491-496.
27 刘佳丽.逍遥散抗抑郁有效部位的PK-PD结合研究.太原:山西大学硕士学位论文,2014.
28 Zhou S,Meng J,Liu B.Investigation into the pharmacokineticpharmacodynamic model of Zingiberis Rhizoma/Zingiberis Rhizoma Carbonisata and contribution to their therapeutic material basis using artificial neural networks.RSC Adv,2017,7,25488-25496.
29 严龙.中药仙茅在大鼠体内的PK-PD模型初探.曲阜:曲阜师范大学硕士学位论文,2014.
30 Li H,Zhang Y,Yu Y P,et al.Pharmacokinetic/pharmacodynamic modeling of antipyretic and reducing plasma concentration of NO effects of Rheum palmatum in rat.Zhongguo Zhong Yao Za Zhi,2013,38(8):1231-1236.
31 Wang X,Lee W Y,Zhou X,et al.A pharmacodynamic-pharmacokinetic(PD-PK)study on the effects of Danshen(Salvia miltiorrhiza)on midazolam,a model CYP3A probe substrate,in the rat.Phytomedicine,2010,17(11):876-883.
32 Lau C,Mooiman K D,Maas-Bakker R F,et al.Effect of Chinese herbs on CYP3A4 activity and expression in vitro.J Ethnopharmacol,2013,149(2):543-549.
33 吕俊兰.基于PD/PK模型的中药日服用次数研究模式的探索.成都:成都中医药大学硕士学位论文,2012.
34 Lv J,Fu S,Guo J,et al.Primary research on daily administration times of rhubarb used to treat experimental jaundice in rats.Zhongguo Zhong Yao Za Zhi,2011,36(24):3506-3510.
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