以4,4’-联苯咪唑构筑的MOFs材料负载大黄素性能研究
|
摘要
以水热合成法合成了一种铜金属聚合物{Cu_2(CHOO)_3(bibp)_2·CHOO}_n,bibp=4,4’-双(咪唑基)联苯。以该聚合物为载体材料,采用物理浸泡法对药物进行装载,比较不同浸泡时间、不同药物材料质量比,筛选最佳药物装置实验参数。采用透析法对其释药性能进行研究。结果最佳浸泡时间为24小时,药物比例1∶1。在不同pH环境下,大黄素分子释放曲线趋势类似。在pH为7.4时,药物释放缓慢。
A functional coorsination polymers namely:{Cu_2(CHOO)_3(bibp)_2·CHOO}_n,(bibp=4,4’-bis(imdazolyl)biphenyl)was synthesized.The physical immersion method was used to investigate the drug loading performance.The optimal drug loading parameters can acquire through comparing the different soaking time and different drug materials quality.Its release characteristics was studied by the dialysis.Results,the optimal soaking time is 24 hours,the drug proportion is1∶1.The releasing curve of emodin molecules is similar under different pH conditions and the releasing behavior is more slow under the pH=7.4.
A functional coorsination polymers namely:{Cu_2(CHOO)_3(bibp)_2·CHOO}_n,(bibp=4,4’-bis(imdazolyl)biphenyl)was synthesized.The physical immersion method was used to investigate the drug loading performance.The optimal drug loading parameters can acquire through comparing the different soaking time and different drug materials quality.Its release characteristics was studied by the dialysis.Results,the optimal soaking time is 24 hours,the drug proportion is1∶1.The releasing curve of emodin molecules is similar under different pH conditions and the releasing behavior is more slow under the pH=7.4.
引文
[1]Janiak C.Engineering coordination polymers towards applications[J].Dalton transaction,2003,14:2781-2804.
[2]郝召民,杜利利,王中英,等.功能MOFs材料的研究进展[J].化学研究,2015,27(2):144-151.
[3]Couvreur P,Gref R,Andrieux K,et al.Nanotechnologies for drug delivery.Application to cancer and autionmmune diseases[J].Progress in Solid State Chemistry,2006,34(2-4):231-235.
[4]Wang Z,Wang P,Tang X.Synthesis of Light-Induced Expandable Photoresponsive Polymeric Nanoparticles for Triggered Release[J].Chem Plus Chem,2013,78(10):1273-1281.
[5]Stock N,Biswas S.Synthesis of metal-organic frameworks(MOFs):rout to various MOF topologies,morphologies,and composites[J].Chemical Reviews,2012,112(2):933-936.
[6]Bosch M,Zhang M,Zhou H C.Increasing the Stability of Metal-Organic Frameworks[J].Advances in Chemistry,2014,2014:1-8.
[7]Cohen S M.Postsynthetic methods for the functionalization of metal-organic frameworks[J].Chemical Reviews,2012,112(2):970-1000.
[8]Ferey G,Mellot-Draznieks C,Serre C,et al.A Chromium Terephthalate-Based Solid with Unusually Large Pore Volumes and Surface Area[J].Science,2005,309(5743):2040-2042.
[9]Horcajada P,Serre C,et al.Metal-Organic Frameworks as Efficient Materials for Drug Delivery[J].Angewandte Chemie-International Edition,2006,118(36):6120-6124.
[10]He Q J,Shi J L.Mesoporous silica nanoparticle based nano drug delivery systems:synthesis,controlled drug release and delivery,pharmacokinetics and biocompatibility[J].Journal of Materials Chemistry,2011,21:5845-5855.
[11]Sun C Y,Qin C,et al.Chiral Nanoporous Metal-Organic Frameworks with High Porosity as Materials for Drug Delivery[J].Advanced Materials,2011,23(47):5629-5632.
[12]Lin W X,Hu Q,Jiang K,et al.A porphyrin-based metal-organic framework as pH-responsive drug carrier[J].Journal of Solid State Chemistry,2016,237:307-312.
[13]林文鑫,生物相容性-有机框架材料的设计、制备及其药物控释性能研究[D].浙江:浙江大学,2016.
[14]Fang K,Zhang L,Hu Q,et al.A Biocompatible Ti-based metal-organic framework for pH responsive drug delivery[J].Materials Letters,2018,225:142-144.
[15]Nadizadeh Z,Naimi-Jamal M R,Panahi L.Mechanochemical solvent-free in situ synthesis of drug-loaded{Cu2(1,4-bdc)2(dabco)}n MOFs for controlled drug delivery[J].Journal of Solid State Chemistry,2018,259:35-42.
[16]张斯时.大黄素的药理作用研究状况[J].中国医药导报,2006,23:12-14.
[17]戴肖南,王其鹏.大黄素/Mg-Al-LDHs纳米杂化物的制备及缓释性能研究[J].无机化学学报,2012,3:560-564.
[18]王其鹏.抗癌药物/LDHs纳米杂化物的制备及性能研究[D].山东:山东轻工业学院,2012.
[19]Zhu Z,Meng X M,Zhang D M,et al,Syntheses,structures and selective dye adsorption of five formic-based coordination polymers prepared by in-situ ydrolysis of N,N′-dimethylformamide[J].Journal of Solid State Chemistry,2017,248:109-118.
[2]郝召民,杜利利,王中英,等.功能MOFs材料的研究进展[J].化学研究,2015,27(2):144-151.
[3]Couvreur P,Gref R,Andrieux K,et al.Nanotechnologies for drug delivery.Application to cancer and autionmmune diseases[J].Progress in Solid State Chemistry,2006,34(2-4):231-235.
[4]Wang Z,Wang P,Tang X.Synthesis of Light-Induced Expandable Photoresponsive Polymeric Nanoparticles for Triggered Release[J].Chem Plus Chem,2013,78(10):1273-1281.
[5]Stock N,Biswas S.Synthesis of metal-organic frameworks(MOFs):rout to various MOF topologies,morphologies,and composites[J].Chemical Reviews,2012,112(2):933-936.
[6]Bosch M,Zhang M,Zhou H C.Increasing the Stability of Metal-Organic Frameworks[J].Advances in Chemistry,2014,2014:1-8.
[7]Cohen S M.Postsynthetic methods for the functionalization of metal-organic frameworks[J].Chemical Reviews,2012,112(2):970-1000.
[8]Ferey G,Mellot-Draznieks C,Serre C,et al.A Chromium Terephthalate-Based Solid with Unusually Large Pore Volumes and Surface Area[J].Science,2005,309(5743):2040-2042.
[9]Horcajada P,Serre C,et al.Metal-Organic Frameworks as Efficient Materials for Drug Delivery[J].Angewandte Chemie-International Edition,2006,118(36):6120-6124.
[10]He Q J,Shi J L.Mesoporous silica nanoparticle based nano drug delivery systems:synthesis,controlled drug release and delivery,pharmacokinetics and biocompatibility[J].Journal of Materials Chemistry,2011,21:5845-5855.
[11]Sun C Y,Qin C,et al.Chiral Nanoporous Metal-Organic Frameworks with High Porosity as Materials for Drug Delivery[J].Advanced Materials,2011,23(47):5629-5632.
[12]Lin W X,Hu Q,Jiang K,et al.A porphyrin-based metal-organic framework as pH-responsive drug carrier[J].Journal of Solid State Chemistry,2016,237:307-312.
[13]林文鑫,生物相容性-有机框架材料的设计、制备及其药物控释性能研究[D].浙江:浙江大学,2016.
[14]Fang K,Zhang L,Hu Q,et al.A Biocompatible Ti-based metal-organic framework for pH responsive drug delivery[J].Materials Letters,2018,225:142-144.
[15]Nadizadeh Z,Naimi-Jamal M R,Panahi L.Mechanochemical solvent-free in situ synthesis of drug-loaded{Cu2(1,4-bdc)2(dabco)}n MOFs for controlled drug delivery[J].Journal of Solid State Chemistry,2018,259:35-42.
[16]张斯时.大黄素的药理作用研究状况[J].中国医药导报,2006,23:12-14.
[17]戴肖南,王其鹏.大黄素/Mg-Al-LDHs纳米杂化物的制备及缓释性能研究[J].无机化学学报,2012,3:560-564.
[18]王其鹏.抗癌药物/LDHs纳米杂化物的制备及性能研究[D].山东:山东轻工业学院,2012.
[19]Zhu Z,Meng X M,Zhang D M,et al,Syntheses,structures and selective dye adsorption of five formic-based coordination polymers prepared by in-situ ydrolysis of N,N′-dimethylformamide[J].Journal of Solid State Chemistry,2017,248:109-118.