摘要
以水热合成法合成了一种铜金属聚合物{Cu_2(CHOO)_3(bibp)_2·CHOO}_n,bibp=4,4’-双(咪唑基)联苯。以该聚合物为载体材料,采用物理浸泡法对药物进行装载,比较不同浸泡时间、不同药物材料质量比,筛选最佳药物装置实验参数。采用透析法对其释药性能进行研究。结果最佳浸泡时间为24小时,药物比例1∶1。在不同pH环境下,大黄素分子释放曲线趋势类似。在pH为7.4时,药物释放缓慢。
A functional coorsination polymers namely:{Cu_2(CHOO)_3(bibp)_2·CHOO}_n,(bibp=4,4’-bis(imdazolyl)biphenyl)was synthesized.The physical immersion method was used to investigate the drug loading performance.The optimal drug loading parameters can acquire through comparing the different soaking time and different drug materials quality.Its release characteristics was studied by the dialysis.Results,the optimal soaking time is 24 hours,the drug proportion is1∶1.The releasing curve of emodin molecules is similar under different pH conditions and the releasing behavior is more slow under the pH=7.4.
引文
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