黄樟素类化合物分析检测研究进展
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摘要
黄樟素类化合物主要包括黄樟素、异黄樟素和二氢黄樟素等,研究表明其对老鼠有致肝肿瘤的效果,2005年实施的《易制毒化学品管理条例》中也将黄樟素列为第一类易制毒化学品。由于该类化合物的毒副作用,建立准确、快速、简便的分析检测方法,对于评估食品、化妆品及烟草的安全性有着重要作用。综述了国内外关于黄樟素类化合物分析检测方面的研究进展,介绍了国内现行标准法规,总结出黄樟素类化合物的研究主要集中在香精香料及化妆品方面。鉴于该类化合物可用作天然除虫菊酯农药增效剂,随着除虫菊酯类农药的大量使用,必将造成它在食品特别是茶叶中的残留;黄樟素也曾是很多食品的添加剂,因其对人体毒害较大,已禁止作为食品添加剂使用,显示出食品中黄樟素类化合物的分析检测的必要性。
Safrole compounds include safrole,isosafrole and dihydrosafrol. Experiments showed that they have liver tumor effect on mice.The implementation of Regulations for Administration of Precursors and Chemicals used in Production of Narcotic Drugs and Psychotropic Substances in 2005 listed safrole as the first class of easy precursor chemical. Because of the toxic and side effects of these compounds,establishing the analysis detection method is accurate,rapid,simple,and playing an important role for the safety assessment of food,cosmetics and tobacco. This paper reviews the domestic and international research on the progress of the detection analysis of safrole compounds,introduces the domestic current standards,summarizes that the research of safrole compounds were mainly concentrated in the flavor fragrance and cosmetics. Safrole compounds can be used as natural pyrethrin pesticide synergist. Along with the extensive use of pyrethroid pesticides,safrole is bound to bring in food especially residues in tea. Safrole was used as food additives,but forbidden for its big toxicity. The necessity for analysis and detection of safrole compounds in food was proposed.
Safrole compounds include safrole,isosafrole and dihydrosafrol. Experiments showed that they have liver tumor effect on mice.The implementation of Regulations for Administration of Precursors and Chemicals used in Production of Narcotic Drugs and Psychotropic Substances in 2005 listed safrole as the first class of easy precursor chemical. Because of the toxic and side effects of these compounds,establishing the analysis detection method is accurate,rapid,simple,and playing an important role for the safety assessment of food,cosmetics and tobacco. This paper reviews the domestic and international research on the progress of the detection analysis of safrole compounds,introduces the domestic current standards,summarizes that the research of safrole compounds were mainly concentrated in the flavor fragrance and cosmetics. Safrole compounds can be used as natural pyrethrin pesticide synergist. Along with the extensive use of pyrethroid pesticides,safrole is bound to bring in food especially residues in tea. Safrole was used as food additives,but forbidden for its big toxicity. The necessity for analysis and detection of safrole compounds in food was proposed.
引文
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[4]MIGLIERINI G.Sassafras oil,a key raw material now largely banned from the market[J].Chemistry today,2008,26(5):59-62.
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[8]SCF.Scientific Committee on Food,European Commission:Opinion of the Scientific Committee on Food on the safety of the presence of safrole(1-allyl-3,4-methylene dioxy benzene)in flavourings and other food ingredients with flavouring properties[S].2002.
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[12]HERP.Ranking Possible Cancer Hazards from Rodent Carcinogens,Using the Human Exposure/Rodent Potency Index(HERP)[S].2011.
[13]HEIKES D L.SFE with GC and MS determination of safrole and related allylbenzenes in sassafras teas[J].Journal of chromatographic science,1994,32(7):253-258.
[14]ZHOU G D,MOORTHY B,BI J,et al.DNA adducts from alkoxyallylbenzene herb and spice constituents in cultured human(Hep G2)cells[J].Environmental and molecular mutagenesis,2007,48(9):715-721.
[15]CHOONG Y M,LIN H J.A rapid and simple gas chromatographic method for direct determination of safrole in soft drinks[J].Journal of food and drug analysis,2001,9(1):27-32.
[16]CURRP,MICALI G,LANUZZA F.Determination ofβ-asarone,safrole,isosafrole,and anethole in alchoholic drinks by high-performance liquid chromatography[J].Journal of chromotography,1987,404:273-278.
[17]吴婷,金其璋.不同食品中侧柏酮、龙蒿脑、黄樟素和甲基丁香酚的含量测定[J].中国食品添加剂,2010(1):223-228.
[18]王星,蔡天培,王超,等.化妆品中黄樟素和6-甲基香豆素的气相色谱-质谱测定法[J].环境与健康杂志,2007,24(5):358-359.
[19]周贻兵,滕明德,张明时.毛细管柱气相色谱法测定烟用香精中黄樟素和香豆素[J].理化检验-化学分册,2011,47(1):39-43.
[20]李长于,李祖光,周示玉,等.气相色谱-串联质谱法测定香精香料中的香豆素和黄樟素[J].质谱学报,2011,32(5):265-270.
[21]MAHESH P,RAJESH KUMAR V.Anti-termite activity of essential oil and its components from Myristica fragrans against Microcerotermes beesoni[J].Journal of applied sciences and environmental management,2011,15(3):559-561.
[22]BARBOSA Q P S,DA CMARA C A G,RAMOS C S,et al.Chemical composition,circadian rhythm and antibacterial activity of essential oils of Piper divaricatum:A new source of safrole[J].Quim nova,2012,35(9):1806-1808.
[23]王海利,孟昭宇,汤建国,等.超高效液相色谱法测定天然提取物中的黄樟素[J].香料香精化妆品,2009(6):11-13.
[24]REYNERTSON K A,BALICK M J,LEE R,et al.A traditional method of Cinnamomum carolinense preparation eliminates safrole from a therapeutic Pohnpean tea[J].Journal of ethnopharmacology,2005,102:269-274.
[25]CHEN C,SPRIANO D,LEHMANN T.Reduction of safrole and methyleugenol in Asari radix et rhizoma by decoction[J].Forsch komplementmed,2009,16(3):162-166.
[26]CUMMINGS K.Sassafras tea:Using a traditional method of preparation to reduce the carcinogenic compound safrole[D].South Carolina Clemson City,United States,Clemson University,2012.
[2]BURDOCK G A.Encyclopedia of food and color additives[M].Florida:CRC Press,1997.
[3]CARLSON M R,THOMPSON D.Liquid chromatographic determination of safrole in sassafras-derived herbal products[J].Journal of AOAC international,1997,80(5):1023-1028.
[4]MIGLIERINI G.Sassafras oil,a key raw material now largely banned from the market[J].Chemistry today,2008,26(5):59-62.
[5]OLTRAMARI A C,WOOD K V,BONHAM C,et al.Safrole analysis by GC-MS of prototrophic(Ocotea odorifera(Vell.)Rohwer)cell cultures[J].Plant cell,tissue,and organ culture,2004,78(3):231-235.
[6]RATSCH C.The encyclopedia of psychoactive plants[M].Vermont:Parkstreet Press,1998.
[7]CFR,Sec.189:Code of Federal Regulations[S].2011.
[8]SCF.Scientific Committee on Food,European Commission:Opinion of the Scientific Committee on Food on the safety of the presence of safrole(1-allyl-3,4-methylene dioxy benzene)in flavourings and other food ingredients with flavouring properties[S].2002.
[9]SCF.Scientific Committee on Food,European Commission:Opinion of the Scientific Committee on Food on Isosafrole[S].2003.
[10]CD-P-SP.Council of Experts on Flavouring Substances(P-SP-AR)[C]//53rd Meeting.Strasbourg,2005:12-14.
[11]WHO.World Health Organization:WHO Food Additives Series:60.Safety evaluation of certain food additives.The 69th Meeting of Joint FAO/WHO Expert Committee on Food Additives[S].2009.
[12]HERP.Ranking Possible Cancer Hazards from Rodent Carcinogens,Using the Human Exposure/Rodent Potency Index(HERP)[S].2011.
[13]HEIKES D L.SFE with GC and MS determination of safrole and related allylbenzenes in sassafras teas[J].Journal of chromatographic science,1994,32(7):253-258.
[14]ZHOU G D,MOORTHY B,BI J,et al.DNA adducts from alkoxyallylbenzene herb and spice constituents in cultured human(Hep G2)cells[J].Environmental and molecular mutagenesis,2007,48(9):715-721.
[15]CHOONG Y M,LIN H J.A rapid and simple gas chromatographic method for direct determination of safrole in soft drinks[J].Journal of food and drug analysis,2001,9(1):27-32.
[16]CURRP,MICALI G,LANUZZA F.Determination ofβ-asarone,safrole,isosafrole,and anethole in alchoholic drinks by high-performance liquid chromatography[J].Journal of chromotography,1987,404:273-278.
[17]吴婷,金其璋.不同食品中侧柏酮、龙蒿脑、黄樟素和甲基丁香酚的含量测定[J].中国食品添加剂,2010(1):223-228.
[18]王星,蔡天培,王超,等.化妆品中黄樟素和6-甲基香豆素的气相色谱-质谱测定法[J].环境与健康杂志,2007,24(5):358-359.
[19]周贻兵,滕明德,张明时.毛细管柱气相色谱法测定烟用香精中黄樟素和香豆素[J].理化检验-化学分册,2011,47(1):39-43.
[20]李长于,李祖光,周示玉,等.气相色谱-串联质谱法测定香精香料中的香豆素和黄樟素[J].质谱学报,2011,32(5):265-270.
[21]MAHESH P,RAJESH KUMAR V.Anti-termite activity of essential oil and its components from Myristica fragrans against Microcerotermes beesoni[J].Journal of applied sciences and environmental management,2011,15(3):559-561.
[22]BARBOSA Q P S,DA CMARA C A G,RAMOS C S,et al.Chemical composition,circadian rhythm and antibacterial activity of essential oils of Piper divaricatum:A new source of safrole[J].Quim nova,2012,35(9):1806-1808.
[23]王海利,孟昭宇,汤建国,等.超高效液相色谱法测定天然提取物中的黄樟素[J].香料香精化妆品,2009(6):11-13.
[24]REYNERTSON K A,BALICK M J,LEE R,et al.A traditional method of Cinnamomum carolinense preparation eliminates safrole from a therapeutic Pohnpean tea[J].Journal of ethnopharmacology,2005,102:269-274.
[25]CHEN C,SPRIANO D,LEHMANN T.Reduction of safrole and methyleugenol in Asari radix et rhizoma by decoction[J].Forsch komplementmed,2009,16(3):162-166.
[26]CUMMINGS K.Sassafras tea:Using a traditional method of preparation to reduce the carcinogenic compound safrole[D].South Carolina Clemson City,United States,Clemson University,2012.