长链非编码RNA与缺血缺氧性疾病的研究进展
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摘要
长链非编码RNA(long non-coding RNA,lnc RNA)是指转录本长度超过200 nt的不编码蛋白质的RNA。lnc RNA在细胞增殖分化、个体发育、干细胞活性与代谢等几乎所有重要生命活动中发挥关键的调控作用,与多种疾病的发生密切相关。近年研究表明,lnc RNA在多种器官缺血缺氧的发生及恢复中发挥着重要的作用。现探讨lnc RNA在缺血缺氧性疾病中的调控机制,重点介绍lnc RNA与缺血性脑卒中和缺血性心脏病的关系,以期为缺血缺氧相关心脑血管疾病的早期预防、诊断和治疗提供新策略。
Long non-coding RNA(lnc RNA) is a group of non-protein coding RNA molecule, and their transcripts are more than 200 nucleotide in length. lnc RNAs play a key regulatory role in a large range of biological processes, such as cell proliferation and differentiation, individual development, stem cell activity and metabolism, and lnc RNA dysfunction can lead to diverse human diseases. Recent studies have shown that lnc RNAs are associated with the occurrence and recovery of multiple organ ischemia and hypoxia. This paper reviews regulation mechanism of lnc RNAs in ischemic and hypoxic diseases and focuses on ischemic stroke and ischemic heart disease, providing a new strategy for early prevention, diagnosis and treatment of hypoxic ischemic cardio-cerebrovascular disease.
Long non-coding RNA(lnc RNA) is a group of non-protein coding RNA molecule, and their transcripts are more than 200 nucleotide in length. lnc RNAs play a key regulatory role in a large range of biological processes, such as cell proliferation and differentiation, individual development, stem cell activity and metabolism, and lnc RNA dysfunction can lead to diverse human diseases. Recent studies have shown that lnc RNAs are associated with the occurrence and recovery of multiple organ ischemia and hypoxia. This paper reviews regulation mechanism of lnc RNAs in ischemic and hypoxic diseases and focuses on ischemic stroke and ischemic heart disease, providing a new strategy for early prevention, diagnosis and treatment of hypoxic ischemic cardio-cerebrovascular disease.
引文
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[2]Ponting CP,Oliver PL,ReikW.Evolution and functions of long non-coding RNAs.Cell,2009,136:629-41
[3]Lipovich L,Johnson R,Lin CY.MacroRNA underdogs in a microRNA world:evolutionary,regulatory,and biomedical significance of mammalian long non proteincoding RNA.Biochim Biophys Acta,2010,1799:597-615
[4]Niazi F,Valadkhan S.Computational analysis of functional long non-coding RNAs reveals lack of peptidecoding capacity and parallels with 3'UTRs.RNA,2012,18:825-43
[5]Salmena L,Poliseno L,Tay Y,et al.A ceRNA hypothesis:the Rosetta Stone of a hidden RNA language.Cell,2011,146:353-8
[6]Venkatraman A,He XC,Thorvaldsen JL,et al.Maternal imprinting at the H19-Igf2 locus maintains adult haematopoietic stem cell quiescence.Nature,2013,500:345-9
[7]Hu W,Yuan B,Flygare J.Long non-coding RNA mediated antiapoptotic activity in murine erythroid terminal differentiation.Genes Dev,2011,25:2573-8
[8]Michalik KM,You X,Manavski Y,et al.Long noncoding RNA MALAT1 regulates endothelial cell function andvessel growth.Circ Res,2014,114:1389-97
[9]陈治,杜钰.血管内皮细胞特异性受体在肿瘤血管靶向治疗中的应用.世界华人消化杂志,2001,9:702-5
[10]Zhou Y,Zhang X,Klibanski A.MEG3 noncoding RNA:a tumor suppressor.Mol Endocrinol,2012,48:R45-53
[11]陈玉娟,欧泽金,常红恩,等.血管内皮功能与冠心病.分子影像学杂志,2014,37:272-3
[12]黄淑亚.长非编码RNA TGFB2-OT1的表达调控及其在血管内皮细胞自噬和炎症中的作用机制研究[D].山东:山东大学,2016
[13]Sawada M,Sawamoto K.Mechanisms of neurogenesis in the normal and injured adult brain.Keio J Med,2013,62:13-28
[14]Huang XP,Ding H,Lu JD,et al.Autophagy in cerebral ischemia and the effects of traditional Chinese medicine.J Intgr Med,2015,13:289-96
[15]Ng SY,Bogu GK,Soh BS,et al.The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis.Mol Cell,2013,51:349-59
[16]Dorn GW.LIPCAR:a mitochondrial lnc in the noncoding RNA chain.Circ Res,2014,114:1548-50
[17]Minger SL,Ekonomou A,Carta EM,et al.Endogenous neurogenesis in the human brain following cerebral infarction.Regen Med,2007,2:69-74
[18]Ng SY,Johnson R,Stanton LW.Human long non-coding RNAs promote pluripotency and neuronal differentiation by association with chromatin modifiers and transcription factors.EMBO J,2012,31:522-33
[19]Sims NR,Muyderman H.Mitochondria,oxidative metabolism and cell death in stroke.Biochim Biophys Acta,2010,1802:80-91
[20]Zhang A,Zhou N,Huang J,et al.The human long noncoding RNARoR is a p53 repressor in response to DNA damage.Cell Res,2013,23:340-50
[21]Thai P,Statt S,Chen CH,et al.Characterization of a novel long non-coding RNA,SCAL1,induced by cigarette smoke and elevated in lung cancer cell lines.Am J Respir Cell Mol Biol,2013,49:204-11
[22]Liu Y,LiG,Lu H,et al.Expression profiling and ontology analysis of long noncoding RNA in post-ischemic heart and their implied roles in ischemia/reperfusion injury.Gene,2014,543:15-21
[23]Liu F,Zhou LY,Long B,et al.A long noncoding RNA,CHRF regulates cardiac hypertrophy by targeting miR-489.Circ Res,2014,114:1377-88
[24]Ross R.Atherosclerosis is an inflammatory disease.Am Heart J,1999,138:S419-20
[25]Kino T,Hurt DE,Ichijo T,et al.Non-coding RNA gas5 is a growth arrestand starvation associated repressor of the glucocorticoid receptor.Sci Signal,2010,3:ra8
[26]李孟婷,李宏帆,杨彬,等.LncRNATUG1在血管内皮细胞功能紊乱中的作用研究.中国分子心脏病学杂志,2016,2:1649-52
[27]Sun L,GoffL A,Trapnell C,et al.Long noncoding RNAs regulate adipogenesis.Proc Natl Acad Sci USA,2013,110:3387-92
[28]Xu B,Gerin I,Miao H,et al.Multiple roles for the noncoding RNA SRA in regulation of adipo genesisand insulin sensitivity.PLoS One,2010,5:el4199
[29]张滨.长链非编码RNA(UCAl)在急性心肌梗死患者血浆中变化水平的研究[D].吉林:吉林大学.2015
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[32]陈真真,罗艳金,贾石,等.小鼠肝脏缺血再灌注损伤后血浆中长链非编码RNA的表达谱[C].上海:中国生理学会第24届全国会员代表大会暨生理学学术大会论文汇编,2014:44-5