调节性T细胞与脑出血的研究进展
摘要
调节性T细胞(Treg)是目前发现唯一一种具有抑制免疫功能的负调控细胞亚群,对于抑制炎症反应、维持免疫稳态、防止自身免疫病起着重要作用。目前认为,炎症反应可以加重脑出血后的二次脑损伤,并在其中发挥重要作用。Treg细胞作为负性免疫调节细胞,能够抑制脑部炎症反应、减轻脑损伤的程度。因此,Treg细胞可以被用来作为急性脑出血细胞免疫治疗的工具和目标。本文将对Treg细胞的生物学特性和功能以及Treg细胞对脑出血影响的最新研究进展作一综述。
引文
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[23]CAI Q,ZHANG H,ZHAO D,et al.Analysis of three surgical treatments for spontaneous supratentorial intracerebral hemorrhage[J].Medicine,2017,96(43):e8435.
[24]CHUNG E S,LEE G,LEE C,et al.Bee venom phospholipase A2,a novel Foxp3+regulatory T cell inducer,protects dopaminergic neurons by modulating neuroinflammatory responses in a mouse model of Parkinson′s disease[J].J Immunol,2015,195(10):4853-4860.
[25]OU H X,GUO B B,LIU Q,et al.Regulatory T cells as a new therapeutic target for atherosclerosis[J].Acta Pharmacol Sin,2018,39(8):1249-1258.
[26]史莉瑾.急性脑出血患者外周血调节性T细胞与脑相关抗原的特征及其相关性研究[D].郑州:郑州大学,2015.
[27]LI P,GAN Y,SUN B L,et al.Adoptive regulatory T-cell therapy protects against cerebral ischemia[J].Ann Neurol,2013,74(3):458-471.
[2]ZHOU Y,WANG Y,WANG J,et al.Inflammation in intracerebral hemorrhage:from mechanisms to clinical translation[J].Prog Neurobiol,2014,115:25-44.
[3]CHEN S,YANG Q,CHEN G,et al.An Update on inflammation in the acute phase of intracerebral hemorrhage[J].Transl Stroke Res,2015,6(1):4-8.
[4]LAN X,HAN X,LI Q,et al.Modulators of microglial activation and polarization after intracerebral haemorrhage[J].Nat Rev Neurol,2017,13(7):420-433.
[5]XU H,QIN W,Hu X,et al.Lentivirus-mediated overexpression of OTULIN ameliorates microglia activation and neuroinflammation by depressing the activation of the NF-κB signaling pathway in cerebral ischemia/reperfusion rats[J].J Neuroinflammation,2018,15(1):83.
[6]YANG Z,LIU Y,YUAN F,et al.Sinomenine inhibits microglia activation and attenuates brain injury in intracerebral hemorrhage[J].Mol Immunol,2014,60(2):109-114.
[7]MRACSKO E,VELTKAMP R.Neuroinflammation after intracerebral hemorrhage[J].Front Cell Neurosci,2014,8(8):388.
[8]JIANG C,ZUO F,WANG Y,et al.Progesterone exerts neuroprotective effects and improves long-term neurologic outcome after intracerebral hemorrhage in middle-aged mice[J].Neurobiol Aging,2016,42:13-24.
[9]ASKENASE M H,SANSING L H.Stages of the inflammatory response in pathology and tissue repair after intracerebral hemorrhage[J].Semin Neurol,2016,36(3):288-297.
[10]ROLLAND W B,LEKIC T,KRAFFT P R,et al.Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage[J].Exp Neurol,2013,241:45-55.
[11]SMIGIEL K S,SRIVASTAVA S,STOLLEY J M,et al.Regulatory T-cell homeostasis:steady-state maintenance and modulation during inflammation[J].Immunol Rev,2014,259(1):40-59.
[12]DEVARAJAN P,MISKA J,LUI J B,et al.Opposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue[J].Am J Immunol,2014,193(9):4368-4380.
[13]GALGANI M,ROSA V D,CAVA A L,et al.Role of metabolism in the immunobiology of regulatory T cells[J].Am J Immunol,2016,197(7):2567.
[14]ZHOU K,ZHONG Q,WANG Y C,et al.Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia/macrophage polarization through the IL-10/GSK3beta/PTEN axis[J].J Cereb Blood Flow Metab,2017,37(3):967-979.
[15]YANG Z,YU A,LIU Y,et al.Regulatory T cells inhibit microglia activation and protect against inflammatory injury in intracerebral hemorrhage[J].Int Immunopharmacol,2014,22(2):522.
[16]MAO L,YUAN H,WANG W,et al.Adoptive regulatory T-cell therapy attenuates perihematomal inflammation in a mouse model of experimental intracerebral hemorrhage[J].Cell Mol Neurobiol,2017,37(5):919-929.
[17]GAO L,LU Q,HUANG L,et al.Transplanted neural stem cells modulate regulatory T,γδT cells and corresponding cytokines after intracerebral hemorrhage in rats[J].Int J Mol Sci,2014,15(12):4431-4441.
[18]EWEN T,QIUTING L,CHAOGANG T,et al.Neuroprotective effect of atorvastatin involves suppression of TNF-alpha and upregulation of IL-10 in a rat model of intracerebral hemorrhage[J].Cell Biochem Biophys,2013,66(2):337-346.
[19]XIE L,CHOUDHURY G R,WINTERS A,et al.Cerebral regulatory T cells restrain microglia/macrophage-mediated inflammatory responses via IL-10[J].Eur J Immunol,2015,45(1):180-191.
[20]王玉静.外源性调节性T细胞减轻小鼠脑出血后炎症并改善长期神经功能预后[D].泰安:泰山医学院,2014.
[21]MENDELOW A D,GREGSON B A,ROWAN E N,et al.Early surgery versus initial conservative treatment in patients with traumatic intracerebral hemorrhage(STITCH[Trauma]):the first randomized trial[J].J Neurotrauma,2015,32(17):1312-1323.
[22]MENDELOW A D,GREGSON B A,ROWAN E N,et al.Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas(STICH II):a randomised trial[J].Lancet,2013,382(9890):397-408.
[23]CAI Q,ZHANG H,ZHAO D,et al.Analysis of three surgical treatments for spontaneous supratentorial intracerebral hemorrhage[J].Medicine,2017,96(43):e8435.
[24]CHUNG E S,LEE G,LEE C,et al.Bee venom phospholipase A2,a novel Foxp3+regulatory T cell inducer,protects dopaminergic neurons by modulating neuroinflammatory responses in a mouse model of Parkinson′s disease[J].J Immunol,2015,195(10):4853-4860.
[25]OU H X,GUO B B,LIU Q,et al.Regulatory T cells as a new therapeutic target for atherosclerosis[J].Acta Pharmacol Sin,2018,39(8):1249-1258.
[26]史莉瑾.急性脑出血患者外周血调节性T细胞与脑相关抗原的特征及其相关性研究[D].郑州:郑州大学,2015.
[27]LI P,GAN Y,SUN B L,et al.Adoptive regulatory T-cell therapy protects against cerebral ischemia[J].Ann Neurol,2013,74(3):458-471.