中医综合疗法治疗睑板腺功能障碍致蒸发过强型干眼临床观察
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摘要
目的探究采用中医综合疗法治疗睑板腺功能障碍致蒸发过强型干眼的临床疗效。方法 22例(40只眼)睑板腺功能障碍致蒸发过强型干眼患者,随机分为观察组和对比组,每组11例(20只眼)。对比组采用0.2%卡波姆滴眼液加妥布霉素地塞米松眼膏进行联合治疗,观察组采用中医综合疗法治疗。比较两组患者眼表疾病指数(OSDI)评分、泪膜破裂时间、睑缘异常评分及治疗效果。结果治疗前,两组患者OSDI评分、泪膜破裂时间、睑缘异常评分比较差异无统计学意义(P>0.05);治疗后,观察组OSDI评分、睑缘异常评分低于对比组,泪膜破裂时间长于对比组,差异具有统计学意义(P<0.05)。观察组患者总有效率为90.00%,高于对比组的60.00%,差异具有统计学意义(P<0.05)。结论采用中医综合疗法治疗睑板腺功能障碍致蒸发过强型干眼,有利于患者睑板腺功能恢复,疗效显著,具有良好的临床价值。
Objective To investigate the clinical efficacy of comprehensive therapy of traditional Chinese medicine in the treatment of evaporative dry eye caused by meibomian gland dysfunction. Methods A total of 22 patients(44 involved eyes) with evaporative dry eye caused by meibomian gland dysfunction were randomly divided into observation group and control group, with 11 cases in each group. The contrast group was treated with 0.2% carbomer eye drops and tobramycin and dexamethasone ophthalmic ointment, and the observation group was treated with comprehensive therapy of traditional Chinese medicine. Comparison were made on ocular surface disease index(OSDI) score, tear film rupture time, margin abnormality score and treatment effect between the two groups. Results Before treatment, both groups had no statistically significant difference in OSDI score, tear film rupture time, margin abnormality score(P>0.05). After treatment, the observation group had lower OSDI score and margin abnormality score, and longer tear film rupture time than the control group. Their difference was statistically significant(P<0.05). The observation group had higher total effective rate as 90.00% than 60.00% in the control group, and the difference was statistically significant(P<0.05). Conclusion Application of comprehensive therapy of traditional Chinese medicine shows remarkable efficacy and good clinical value in treating evaporative dry eye caused by meibomian gland dysfunction, and it is beneficial to the recovery of the function of the eyelid gland.
Objective To investigate the clinical efficacy of comprehensive therapy of traditional Chinese medicine in the treatment of evaporative dry eye caused by meibomian gland dysfunction. Methods A total of 22 patients(44 involved eyes) with evaporative dry eye caused by meibomian gland dysfunction were randomly divided into observation group and control group, with 11 cases in each group. The contrast group was treated with 0.2% carbomer eye drops and tobramycin and dexamethasone ophthalmic ointment, and the observation group was treated with comprehensive therapy of traditional Chinese medicine. Comparison were made on ocular surface disease index(OSDI) score, tear film rupture time, margin abnormality score and treatment effect between the two groups. Results Before treatment, both groups had no statistically significant difference in OSDI score, tear film rupture time, margin abnormality score(P>0.05). After treatment, the observation group had lower OSDI score and margin abnormality score, and longer tear film rupture time than the control group. Their difference was statistically significant(P<0.05). The observation group had higher total effective rate as 90.00% than 60.00% in the control group, and the difference was statistically significant(P<0.05). Conclusion Application of comprehensive therapy of traditional Chinese medicine shows remarkable efficacy and good clinical value in treating evaporative dry eye caused by meibomian gland dysfunction, and it is beneficial to the recovery of the function of the eyelid gland.
引文
[1]顾宇亮.蒸发过强型干眼的中医辨证分型及相关性研究.南京中医药大学,2017.
[2]袁进英.清眩润目饮内外并用治疗MGD所致干眼的临床观察.黑龙江中医药大学,2016.
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[4]宋立,唐万华,俞兴源,等.雷火灸治疗干眼临床验证方案疗效的多中心观察.中国中医眼科杂志,2015,25(2):98-101.
[5]王磊,张磊,王亚娜,等.补肾丸合明目五子治疗干眼症的临床疗效.国际眼科杂志,2017,17(8):1593-1595.
[6]王佳娣,姚靖.中医综合疗法治疗睑板腺功能障碍致蒸发过强型干眼疗效观察.中医药学报,2016,44(4):130-132.
[7]姚靖,王佳娣,谢广芳.中药清眩润目饮治疗睑板腺功能障碍致蒸发过强型干眼60例的临床观察.中医药学报,2014,42(5):51-53.
[8]高珺禛.综合疗法治疗睑板腺功能障碍致蒸发过强性干眼的临床观察.中国中医眼科杂志,2013,23(6):436-438.
[9]吴樨,胡雪飞,刘静.物理疗法治疗睑板腺功能障碍所致干眼168例.贵阳医学院学报,2012,37(5):568-569.
[10]陈媛.中药热奄包联合睑板腺按摩治疗睑板腺功能障碍合并蒸发过强型干眼.中医眼耳鼻喉杂志,2014,4(2):79-80.
[2]袁进英.清眩润目饮内外并用治疗MGD所致干眼的临床观察.黑龙江中医药大学,2016.
[3]杨帆,曾庆延.睑板腺功能障碍治疗进展.眼科新进展,2016,36(10):996-1000.
[4]宋立,唐万华,俞兴源,等.雷火灸治疗干眼临床验证方案疗效的多中心观察.中国中医眼科杂志,2015,25(2):98-101.
[5]王磊,张磊,王亚娜,等.补肾丸合明目五子治疗干眼症的临床疗效.国际眼科杂志,2017,17(8):1593-1595.
[6]王佳娣,姚靖.中医综合疗法治疗睑板腺功能障碍致蒸发过强型干眼疗效观察.中医药学报,2016,44(4):130-132.
[7]姚靖,王佳娣,谢广芳.中药清眩润目饮治疗睑板腺功能障碍致蒸发过强型干眼60例的临床观察.中医药学报,2014,42(5):51-53.
[8]高珺禛.综合疗法治疗睑板腺功能障碍致蒸发过强性干眼的临床观察.中国中医眼科杂志,2013,23(6):436-438.
[9]吴樨,胡雪飞,刘静.物理疗法治疗睑板腺功能障碍所致干眼168例.贵阳医学院学报,2012,37(5):568-569.
[10]陈媛.中药热奄包联合睑板腺按摩治疗睑板腺功能障碍合并蒸发过强型干眼.中医眼耳鼻喉杂志,2014,4(2):79-80.