无溶剂条件下通过锌铜偶促进的Barbier反应合成羧酸酯
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摘要
在锌酮偶的促进下,通过Barbier反应以醛、溴代烃和酸酐为原料,在无溶剂非催化条件下三组分"一锅法"反应合成了一系列高烯丙基酯、高炔丙基酯和β-乙酰氧基酯类化合物.对反应条件及历程也进行了探讨.该方法具有反应条件温和、操作简单、产率高、原料易得、反应迅速的特点.
A series of homoallyl esters, homopropargyl esters and β-acetoxyl esters were obtained via Barbier reaction from one pot three component reaction of aldehydes, bromohydrocarbons and anhydrides mediated by zinc copper couple under non-catalytic and solvent-free conditions. The studies on the reaction conditions and the reaction mechanism were also carried out. This protocol has advantages of mild conditions, simple work-up, high yield, easily available starting materials and fast reaction rate.
A series of homoallyl esters, homopropargyl esters and β-acetoxyl esters were obtained via Barbier reaction from one pot three component reaction of aldehydes, bromohydrocarbons and anhydrides mediated by zinc copper couple under non-catalytic and solvent-free conditions. The studies on the reaction conditions and the reaction mechanism were also carried out. This protocol has advantages of mild conditions, simple work-up, high yield, easily available starting materials and fast reaction rate.
引文
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