核因子-κB与肝纤维化中医药治疗研究进展
|
摘要
<正>肝纤维化(alcoholic liver fibrosis,ALF)是各种原因所引起的慢性肝病共同的病理性特征,是指肝细胞发生坏死及炎症刺激时,肝脏中胶原蛋白等细胞外基质(extracellular matrix,ECM)的增生与降解失去平衡,致使ECM在肝脏内过度沉积的纤维增生性疾病[1]。肝纤维化持续发展最终可导致肝硬化,如不及时治疗则可能进展为失代偿期肝硬化并出现各种终末期肝病的并发症,如肝硬化腹水、门脉高压出血、失血性
引文
[1]Su X,Wang Y,Zhou G,et al.Probucol attenuates ethanol-induced liver fibrosis in rats by inhibiting oxidative stress,extracellular matrix protein accumulation and cytokine production[J].Clin Exp Pharmacol Physiol,2014,41(1):73-80
[2]Zhao WX,Wang L,Yang JL,et,al.Caffeic acid phenethyl ester attenuates pro-inflammatory and fibrogenic phenotypes of LPS-stimulated hepatic stellate cells through the inhibition of NF-κB signaling[J].Int J Mol Med,2014,33(3):687-694
[3]Sun K,Chen Y,Liang SY,et al.Effect of taurine on IRAK4 and NFkappa B in Kupffer cells from rat liver grafts after ischemia-reperfusion injury[J].Am J Surg,2012,204(3):389-395
[4]Kang KH,Qian ZJ,Ryu B,et al.Hepatic fibrosis inhibitory effect of peptides isolated from navicula incerta on TGF-β1induced activation of LX-2 human hepatic stellate cells[J].Prev Nutr Food Sci,2013,18(2):124-32.
[5]Wang R,Yu XY,Guo ZY,et al.Inhibitory effects of salvianolic acid B on CCl(4)-induced hepatic fibrosis through regulating NF-κB/IκBαsignaling[J].J Ethnopharmacol,2012,18:144(3):592-598
[6]Kisseleva T,Brenner DA.Role of Hepatic stellate cells in fibrogenesis and reversal of fibrosis[J].J Gastroenterol Hepatol,2007,22(Suppl 1):S73-78
[7]Cui D,Zhong S,Ma J,et al.Short interfering RNA targetting NFkappa B induces apoptosis of hepatic stellate cells and attenuates extracellular matrix production[J].Diq Liver Dis,2010,42(11):813-817
[8]Mao Z,Li Y,Peng Y,et al.Lipopolysaccharide down-regulates carbolesterases 1and 2 and reduces hydrolysis activity in vitro and in vivo via p38MAPK-NF-κB pathway[J].Toxicol Lett,2011,201(3):213-220
[9]Sehoemaker MH,Ros JE,Homan M,et al.Cytokine regulation of pro-and anti-apoptotic genes in rat hepatocytes:NF-kappa B regulated inhibitor of apoptosis protein 2(CIAP-2)prevents apoptosis[J].J Hepatol,2002,36(6):742-750
[10]Szuster-Ciesielska A,Mizerska-Dudka M,Daniluk J,et,al.Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β,NFκB,p38,and JNK signaling pathways and inhibition of oxidative stress[J].J Gastroenterol,2013,48(2):222-237
[11]Yang J,Su Y,Richmond A.Antioxidants tiron and N-acetyl-Lcysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species independent NF-kappa B pathway[J].Free Radic Biol Med.2007,42(9):1369-1380
[12]杨沈秋,张金良,张禹,等.软肝散治疗慢性乙型肝炎肝纤维化的临床研究[J].中国中医药科技,2012,19(4):301-302
[13]刘绍能,刘为民.从络脉理论探讨肝纤维化证治规律[J].中国中医药信息杂志,2003,7(10):4
[14]贺松其,张绪富,蔡红兵.吕志平教授辨治慢性肝炎肝纤维化经验介绍[J].新中医,2005,37(3):16-17
[15]中国中西医结合学会肝病专业委员会.肝纤维化中西医结合诊疗指南[J].中西医结合杂志,2006,26(11):866-869
[16]高志扬,易向明.慢性乙型肝炎防治肝纤维化的中医论治对策[J].光明中医,2007,22(10):10-11
[17]付月箫.肝纤维化的辨证思路的探讨[J].光明中医,2008,23(10):1430-1431
[18]孙晓慧,罗玮敏,宋霆,等.疏肝健脾化瘀法对乙型肝炎早期肝硬化患者相关血清学指标的影响[J].中西医结合肝病杂志,2012,22(5):268-270
[19]王继,陈俊红,李兵顺.活血、益气、软坚不同中医治则逆转大鼠肝纤维化的实验观察[J].中国中医基础医学杂志,2006,12(6):420-422
[20]陈丹丹,龚作炯.小柴胡汤治疗慢性乙型肝炎肝纤维化的临床研究[J].现代中西医结合杂志,2011,20(31):3928-3930
[21]王付,尚立芝,苗小玲,等.四逆散加味治疗肝纤维化的临床疗效观察[J].中医药通报,2012,11(1):42-44
[22]谢鸿昌,吴昊星,程建书.鳖甲煎丸治疗血吸虫病肝纤维化临床观察[J].湖北中医杂志,2012,34(9):37
[23]黄正明.丹参酮A联合苦参素抗肝纤维化43例临床观察[J].吉林医学,2010,31(31):5549-5550
[24]Féher J,Lengyel G.Silymarin in the prevention and treatment of liver diseases and primary liver cancer[J].Curr Pharm Biotechnol,2012,Jan,13(1):210-217
[25]张小斌,曾令兰,陈莎燕,等.姜黄素对肝纤维化模型大鼠肝纤维化组织细胞因子的影响[J].医药导报,2011,30(4):443-446
[26]刘珺,徐选福,郭传勇,等.贝母辛抗大鼠肝纤维化的作用研究[J].中草药,2013,44(11):1455-1459
[27]董妙先,綦艳秋,朱兰芹,等.大黄素对肝纤维化大鼠肝脏组织中I型前胶原mRNA表达的影响[J].齐齐哈尔医学院学报,2013,34(14):2029-2030
[28]路赛,张诗剑,李静,等.柴胡皂苷-d抑制大鼠肝星状细胞增殖的实验研究[J].承德医学院学报,2013,30(4):346-347
[29]高淑俊,常丽萍.六味五灵片联合阿德福韦酯治疗HBe Ag阴性慢性乙型肝炎[J].传染病信息,2011,24(1):214-216
[30]梁贤栋,刘美静,李园园.鳖甲煎丸联合恩替卡韦对乙肝肝纤维化的疗效观察[J].中国现代药物应用,2015,9(7):6-8
[31]周立文,葛伟伟,张雅丽.复方鳖甲软肝方血清防治肝纤维化作用机制的实验研究[J].中国生化药物杂志,2015,35(1):60-67
[32]白辰,车念聪,刘文兰.一贯煎对大鼠肝纤维化拮抗作用的影响[J].中华中医药杂志,2015,30(3):815-817
[2]Zhao WX,Wang L,Yang JL,et,al.Caffeic acid phenethyl ester attenuates pro-inflammatory and fibrogenic phenotypes of LPS-stimulated hepatic stellate cells through the inhibition of NF-κB signaling[J].Int J Mol Med,2014,33(3):687-694
[3]Sun K,Chen Y,Liang SY,et al.Effect of taurine on IRAK4 and NFkappa B in Kupffer cells from rat liver grafts after ischemia-reperfusion injury[J].Am J Surg,2012,204(3):389-395
[4]Kang KH,Qian ZJ,Ryu B,et al.Hepatic fibrosis inhibitory effect of peptides isolated from navicula incerta on TGF-β1induced activation of LX-2 human hepatic stellate cells[J].Prev Nutr Food Sci,2013,18(2):124-32.
[5]Wang R,Yu XY,Guo ZY,et al.Inhibitory effects of salvianolic acid B on CCl(4)-induced hepatic fibrosis through regulating NF-κB/IκBαsignaling[J].J Ethnopharmacol,2012,18:144(3):592-598
[6]Kisseleva T,Brenner DA.Role of Hepatic stellate cells in fibrogenesis and reversal of fibrosis[J].J Gastroenterol Hepatol,2007,22(Suppl 1):S73-78
[7]Cui D,Zhong S,Ma J,et al.Short interfering RNA targetting NFkappa B induces apoptosis of hepatic stellate cells and attenuates extracellular matrix production[J].Diq Liver Dis,2010,42(11):813-817
[8]Mao Z,Li Y,Peng Y,et al.Lipopolysaccharide down-regulates carbolesterases 1and 2 and reduces hydrolysis activity in vitro and in vivo via p38MAPK-NF-κB pathway[J].Toxicol Lett,2011,201(3):213-220
[9]Sehoemaker MH,Ros JE,Homan M,et al.Cytokine regulation of pro-and anti-apoptotic genes in rat hepatocytes:NF-kappa B regulated inhibitor of apoptosis protein 2(CIAP-2)prevents apoptosis[J].J Hepatol,2002,36(6):742-750
[10]Szuster-Ciesielska A,Mizerska-Dudka M,Daniluk J,et,al.Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β,NFκB,p38,and JNK signaling pathways and inhibition of oxidative stress[J].J Gastroenterol,2013,48(2):222-237
[11]Yang J,Su Y,Richmond A.Antioxidants tiron and N-acetyl-Lcysteine differentially mediate apoptosis in melanoma cells via a reactive oxygen species independent NF-kappa B pathway[J].Free Radic Biol Med.2007,42(9):1369-1380
[12]杨沈秋,张金良,张禹,等.软肝散治疗慢性乙型肝炎肝纤维化的临床研究[J].中国中医药科技,2012,19(4):301-302
[13]刘绍能,刘为民.从络脉理论探讨肝纤维化证治规律[J].中国中医药信息杂志,2003,7(10):4
[14]贺松其,张绪富,蔡红兵.吕志平教授辨治慢性肝炎肝纤维化经验介绍[J].新中医,2005,37(3):16-17
[15]中国中西医结合学会肝病专业委员会.肝纤维化中西医结合诊疗指南[J].中西医结合杂志,2006,26(11):866-869
[16]高志扬,易向明.慢性乙型肝炎防治肝纤维化的中医论治对策[J].光明中医,2007,22(10):10-11
[17]付月箫.肝纤维化的辨证思路的探讨[J].光明中医,2008,23(10):1430-1431
[18]孙晓慧,罗玮敏,宋霆,等.疏肝健脾化瘀法对乙型肝炎早期肝硬化患者相关血清学指标的影响[J].中西医结合肝病杂志,2012,22(5):268-270
[19]王继,陈俊红,李兵顺.活血、益气、软坚不同中医治则逆转大鼠肝纤维化的实验观察[J].中国中医基础医学杂志,2006,12(6):420-422
[20]陈丹丹,龚作炯.小柴胡汤治疗慢性乙型肝炎肝纤维化的临床研究[J].现代中西医结合杂志,2011,20(31):3928-3930
[21]王付,尚立芝,苗小玲,等.四逆散加味治疗肝纤维化的临床疗效观察[J].中医药通报,2012,11(1):42-44
[22]谢鸿昌,吴昊星,程建书.鳖甲煎丸治疗血吸虫病肝纤维化临床观察[J].湖北中医杂志,2012,34(9):37
[23]黄正明.丹参酮A联合苦参素抗肝纤维化43例临床观察[J].吉林医学,2010,31(31):5549-5550
[24]Féher J,Lengyel G.Silymarin in the prevention and treatment of liver diseases and primary liver cancer[J].Curr Pharm Biotechnol,2012,Jan,13(1):210-217
[25]张小斌,曾令兰,陈莎燕,等.姜黄素对肝纤维化模型大鼠肝纤维化组织细胞因子的影响[J].医药导报,2011,30(4):443-446
[26]刘珺,徐选福,郭传勇,等.贝母辛抗大鼠肝纤维化的作用研究[J].中草药,2013,44(11):1455-1459
[27]董妙先,綦艳秋,朱兰芹,等.大黄素对肝纤维化大鼠肝脏组织中I型前胶原mRNA表达的影响[J].齐齐哈尔医学院学报,2013,34(14):2029-2030
[28]路赛,张诗剑,李静,等.柴胡皂苷-d抑制大鼠肝星状细胞增殖的实验研究[J].承德医学院学报,2013,30(4):346-347
[29]高淑俊,常丽萍.六味五灵片联合阿德福韦酯治疗HBe Ag阴性慢性乙型肝炎[J].传染病信息,2011,24(1):214-216
[30]梁贤栋,刘美静,李园园.鳖甲煎丸联合恩替卡韦对乙肝肝纤维化的疗效观察[J].中国现代药物应用,2015,9(7):6-8
[31]周立文,葛伟伟,张雅丽.复方鳖甲软肝方血清防治肝纤维化作用机制的实验研究[J].中国生化药物杂志,2015,35(1):60-67
[32]白辰,车念聪,刘文兰.一贯煎对大鼠肝纤维化拮抗作用的影响[J].中华中医药杂志,2015,30(3):815-817