NT和NF在胎儿染色体异常检测中的应用价值
|
摘要
目的分析颈项透明层(nuchal translucency,NT)与颈后皮肤皱褶(nuchal fold,NF)在胎儿染色体异常检测中的应用价值。方法选取2015年1月至2016年12月本院经产科超声检查提示为NT和NF增厚的孕妇69例作为研究对象,所有孕妇均行介入性产前诊断,分析NT和NF对染色体异常检出率的影响。结果超声检查提示:NT增厚孕妇共35例,绒毛培养发现染色体异常8例,检出率为22.9%。超声检查提示:NF增厚孕妇共34例,羊水培养发现染色体异常4例,检出率为11.8%。结论 NT和NF增厚在染色体异常胎儿筛查中具有重要的应用价值,能够尽早发现孕早/中期的染色体异常胎儿。
Objective To analyze the value of nuchal translucency(NT) and nuchal fold(NF) in the detection of fetal chromosomal abnormalities. Method From January 2015 to December 2016, 69 pregnant women who underwent obstetric ultrasonography for NT and NF in our hospital were selected as research subjects. All pregnant women underwent interventional prenatal diagnosis, the detection rates of NT and NF on chromosomal abnormalities were analyzed. Result Ultrasonography showed that there were 35 pregnant women with NT thickening, 8 cases of chromosomal abnormalities found in villus culture, the detection rate was 22.9%. Ultrasonography showed that there were 34 pregnant women with NF thickening, 4 cases of chromosomal abnormalities were found in amniotic fluid culture, the detection rate was 11.8%. Conclusion The thickening of NT and NF in fetal screening of chromosomal abnormalities has an important value in application. Early detection of fetal chromosomal abnormalities in early/middle gestational stages.
Objective To analyze the value of nuchal translucency(NT) and nuchal fold(NF) in the detection of fetal chromosomal abnormalities. Method From January 2015 to December 2016, 69 pregnant women who underwent obstetric ultrasonography for NT and NF in our hospital were selected as research subjects. All pregnant women underwent interventional prenatal diagnosis, the detection rates of NT and NF on chromosomal abnormalities were analyzed. Result Ultrasonography showed that there were 35 pregnant women with NT thickening, 8 cases of chromosomal abnormalities found in villus culture, the detection rate was 22.9%. Ultrasonography showed that there were 34 pregnant women with NF thickening, 4 cases of chromosomal abnormalities were found in amniotic fluid culture, the detection rate was 11.8%. Conclusion The thickening of NT and NF in fetal screening of chromosomal abnormalities has an important value in application. Early detection of fetal chromosomal abnormalities in early/middle gestational stages.
引文
[1]马涛,杨晓,岳军,等.妊娠中晚期超声软指标与胎儿染色体异常及其围生结局[J].实用妇产科杂志,2017,33(2):110-113.
[2]李载红,洪燕,覃伶伶,等.超声检查颈项透明层增厚在胎儿染色体异常诊断中的应用价值[J].实用医学杂志,2016,32(3):402-405.
[3]顾蔚蓉,李笑天,严英榴,等.产前诊断中胎儿超声软指标阳性的临床处理与预后分析[J].复旦学报(医学版),2010,37(2):180-183,188.
[4]朱继红.产前超声软指标检查与母体血清学联合检测筛查胎儿染色体异常[J].中国临床医学影像杂志,2016,27(1):38-41.
[5]黄竹娟,韦业平,黄燕.产前检查对妊娠结局和围生儿状况的影响[J].中国医药导报,2011,8(32):47-48.
[6]顾京红,蒋荣珍,沈国芳,等.598例妊娠中晚期胎儿超声异常与染色体异常的关系[J].实用妇产科杂志,2015,31(2):139-143.
[7]任芸芸,李笑天,严英榴,等.中孕期超声筛查胎儿染色体异常软指标的临床价值[J].中国实用妇科与产科杂志,2008,24(1):41-43.
[8]叶亚梅.孕早期不同超声异常指标在筛查胎儿染色体异常中的临床价值[J].中国医学前沿杂志(电子版),2017,9(2):154-158.
[9]王焱,陈佳,段钰萍,等.孕早期胎儿超声指标在21-三体综合征中的诊断价值[J].中国医学前沿杂志(电子版),2017,9(6):78-81
[10]周祎,鲁云涯,陈涌珍,等.颈项透明层增厚胎儿的产前诊断及预后分析[J].中山大学学报(医学科学版),2013,34(6):888-893.
[11]裴秋艳,张晓红,李建国,等.胎儿颈项透明层增厚及静脉导管血流频谱异常在先天性心脏畸形筛查中的价值[J].中国超声医学杂志,2011,27(2):169-172.
[12]孙丽娟,王欣,吴青青,等.超声检查胎儿颈项透明层厚度在筛查胎儿染色体异常中的价值[J].中华妇产科杂志,2013,48(11):819-823.
[13]刘丽华,卢小青,刘聪慧,等.胎儿颈项透明层厚度联合血清学检测在唐氏综合征筛查中的应用[J].中国妇幼保健,2013,28(17):2715-2717.
[14]宋桂宁,梁梅英,魏艳秋,等.胎儿颈项透明层增厚与染色体异常的关系[J].中国妇产科临床杂志,2011,12(4):265-267.
[15]李晓霞,张丽明,刘继凤,等.彩超检测胎儿颈项透明层厚度与胎儿发育异常的应用研究[J].实用妇产科杂志,2012,28(8):688-691.
[16]朱继红,文珂.胎儿鼻骨、颈项透明层厚度与母体血清学检测联合筛查唐氏综合征[J].中国现代医学杂志,2016,26(22):50-53.
[17]刘灿,王坤,李丽霞,等.胎儿颈项透明层联合中孕产前无创DNA检测在胎儿染色体疾病产前筛查中的应用[J].实用医学杂志,2015,31(22):3753-3755.
[18]王挺,郭莉,陈汉彪,等.早期产前筛查中胎儿颈项透明层厚度与绒毛染色体异常的相关性研究[J].中华医学遗传学杂志,2016,33(2):264-265.
[19]王丽,杨青松.孕11-13+6周超声软指标在胎儿染色体异常筛查中的应用效果[J].中国全科医学,2017,20(S1):249-251.
[20]江洪,何心勤,林元.不同类型先天性心脏病胎儿染色体异常特征分析[J].山东医药,2016,56(46):65-68.
[2]李载红,洪燕,覃伶伶,等.超声检查颈项透明层增厚在胎儿染色体异常诊断中的应用价值[J].实用医学杂志,2016,32(3):402-405.
[3]顾蔚蓉,李笑天,严英榴,等.产前诊断中胎儿超声软指标阳性的临床处理与预后分析[J].复旦学报(医学版),2010,37(2):180-183,188.
[4]朱继红.产前超声软指标检查与母体血清学联合检测筛查胎儿染色体异常[J].中国临床医学影像杂志,2016,27(1):38-41.
[5]黄竹娟,韦业平,黄燕.产前检查对妊娠结局和围生儿状况的影响[J].中国医药导报,2011,8(32):47-48.
[6]顾京红,蒋荣珍,沈国芳,等.598例妊娠中晚期胎儿超声异常与染色体异常的关系[J].实用妇产科杂志,2015,31(2):139-143.
[7]任芸芸,李笑天,严英榴,等.中孕期超声筛查胎儿染色体异常软指标的临床价值[J].中国实用妇科与产科杂志,2008,24(1):41-43.
[8]叶亚梅.孕早期不同超声异常指标在筛查胎儿染色体异常中的临床价值[J].中国医学前沿杂志(电子版),2017,9(2):154-158.
[9]王焱,陈佳,段钰萍,等.孕早期胎儿超声指标在21-三体综合征中的诊断价值[J].中国医学前沿杂志(电子版),2017,9(6):78-81
[10]周祎,鲁云涯,陈涌珍,等.颈项透明层增厚胎儿的产前诊断及预后分析[J].中山大学学报(医学科学版),2013,34(6):888-893.
[11]裴秋艳,张晓红,李建国,等.胎儿颈项透明层增厚及静脉导管血流频谱异常在先天性心脏畸形筛查中的价值[J].中国超声医学杂志,2011,27(2):169-172.
[12]孙丽娟,王欣,吴青青,等.超声检查胎儿颈项透明层厚度在筛查胎儿染色体异常中的价值[J].中华妇产科杂志,2013,48(11):819-823.
[13]刘丽华,卢小青,刘聪慧,等.胎儿颈项透明层厚度联合血清学检测在唐氏综合征筛查中的应用[J].中国妇幼保健,2013,28(17):2715-2717.
[14]宋桂宁,梁梅英,魏艳秋,等.胎儿颈项透明层增厚与染色体异常的关系[J].中国妇产科临床杂志,2011,12(4):265-267.
[15]李晓霞,张丽明,刘继凤,等.彩超检测胎儿颈项透明层厚度与胎儿发育异常的应用研究[J].实用妇产科杂志,2012,28(8):688-691.
[16]朱继红,文珂.胎儿鼻骨、颈项透明层厚度与母体血清学检测联合筛查唐氏综合征[J].中国现代医学杂志,2016,26(22):50-53.
[17]刘灿,王坤,李丽霞,等.胎儿颈项透明层联合中孕产前无创DNA检测在胎儿染色体疾病产前筛查中的应用[J].实用医学杂志,2015,31(22):3753-3755.
[18]王挺,郭莉,陈汉彪,等.早期产前筛查中胎儿颈项透明层厚度与绒毛染色体异常的相关性研究[J].中华医学遗传学杂志,2016,33(2):264-265.
[19]王丽,杨青松.孕11-13+6周超声软指标在胎儿染色体异常筛查中的应用效果[J].中国全科医学,2017,20(S1):249-251.
[20]江洪,何心勤,林元.不同类型先天性心脏病胎儿染色体异常特征分析[J].山东医药,2016,56(46):65-68.