非洛地平缓释片联合草酸艾司西酞普兰片对高血压病伴抑郁症患者血清甲状腺激素水平的影响
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摘要
目的:探讨非洛地平缓释片联合草酸艾司西酞普兰片对高血压病伴抑郁症患者血清甲状腺激素水平的影响。方法:选取2018年1月至2019年1月广西脑科医院收治的高血压病伴抑郁症患者120例,根据随机数字表法分为观察组和对照组,每组60例。对照组患者给予非洛地平缓释片,观察组患者给予非洛地平缓释片联合草酸艾司西酞普兰片。比较两组患者的临床疗效、血压[收缩压(SBP)、舒张压(DBP)]水平、焦虑抑郁评分、血清甲状腺激素[促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT3)及游离甲状腺素(FT4)]水平、生活质量评分及不良反应发生情况的差异。结果:观察组患者的总有效率为96.67%(58/60),明显高于对照组的83.33%(50/60),差异有统计学意义(P<0.05)。治疗后,观察组患者的SBP、DBP、FT3及FT4水平,汉密尔顿焦虑量表评分及汉密尔顿抑郁量表评分明显低于对照组,TSH水平和生理健康、心理健康、生活环境及社会关系评分明显高于对照组,上述差异均有统计学意义(P<0.05)。两组患者在治疗期间均未发生明显不良反应。结论:非洛地平缓释片联合草酸艾司西酞普兰片治疗高血压病伴抑郁症的疗效良好,可有效纠正甲状腺激素紊乱,控制血压,减轻抑郁症状,安全性好。
OBJECTIVE: To investigate the effects of Felodipine sustained-release tablets combined with Escitalopram oxalate tablets on serum thyroid hormone levels in patients with hypertension and depression. METHODS: Totally 120 patients with hypertension and depression admitted into Guangxi Brain Hospital from Jan. 2018 to Jan. 2019 were extracted to be divided into the observation group and the control group via the random number table, with 60 cases in each group. The control group was given Felodipine sustained-release tablets, while the observation group received Felodipine sustained-release tablets combined with Escitalopram oxalate tablets. Differences of clinical efficacy, blood pressure [systolic blood pressure(SBP), diastolic blood pressure(DBP)] level, anxiety and depression score, serum thyroid hormone [thyroid stimulating hormone(TSH), free triiodothyronine(FT3) and free thyroxine(FT4)] levels, quality of life scores and adverse drug reactions of two groups were compared. RESULTS: The total effective rate of the observation group was 96.67%(58/60), significantly higher than that of the control group [83.33%(50/60)], the difference was statistically significant(P<0.05). After treatment, the SBP, DBP, FT3, FT4 levels, Hamilton anxiety scale scores and Hamilton depression scale scores of the observation group were significantly lower than those of the control group, the TSH level, physical health, mental health, living environment and social relationship scores were significantly higher than those of the control group, and the differences were statistically significant(P<0.05). There were no significant adverse drug reactions in both groups of patients. CONCLUSIONS: The efficacy of Felodipine sustained-release tablets combined with Escitalopram oxalate tablets on serum thyroid hormone levels in treatment of patients with hypertension and depression is significant, which can effectively correct the thyroid hormone disorders, control the blood pressure, and reduce the depressive symptoms with higher safety.
OBJECTIVE: To investigate the effects of Felodipine sustained-release tablets combined with Escitalopram oxalate tablets on serum thyroid hormone levels in patients with hypertension and depression. METHODS: Totally 120 patients with hypertension and depression admitted into Guangxi Brain Hospital from Jan. 2018 to Jan. 2019 were extracted to be divided into the observation group and the control group via the random number table, with 60 cases in each group. The control group was given Felodipine sustained-release tablets, while the observation group received Felodipine sustained-release tablets combined with Escitalopram oxalate tablets. Differences of clinical efficacy, blood pressure [systolic blood pressure(SBP), diastolic blood pressure(DBP)] level, anxiety and depression score, serum thyroid hormone [thyroid stimulating hormone(TSH), free triiodothyronine(FT3) and free thyroxine(FT4)] levels, quality of life scores and adverse drug reactions of two groups were compared. RESULTS: The total effective rate of the observation group was 96.67%(58/60), significantly higher than that of the control group [83.33%(50/60)], the difference was statistically significant(P<0.05). After treatment, the SBP, DBP, FT3, FT4 levels, Hamilton anxiety scale scores and Hamilton depression scale scores of the observation group were significantly lower than those of the control group, the TSH level, physical health, mental health, living environment and social relationship scores were significantly higher than those of the control group, and the differences were statistically significant(P<0.05). There were no significant adverse drug reactions in both groups of patients. CONCLUSIONS: The efficacy of Felodipine sustained-release tablets combined with Escitalopram oxalate tablets on serum thyroid hormone levels in treatment of patients with hypertension and depression is significant, which can effectively correct the thyroid hormone disorders, control the blood pressure, and reduce the depressive symptoms with higher safety.
引文
[1] 张弭,黄健,莫新玲.氟西汀治疗老年高血压伴抑郁症患者的效果[J].中国医药导报,2014,11(14):70-73.
[2] 陈健.运动疗法在高血压合并抑郁症患者中的干预性研究[J].中国医学创新,2016,13(15):103-105.
[3] 刘晓峥,陈勤.西酞普兰联合降压药治疗原发性高血压伴焦虑抑郁患者疗效观察[J].现代医药卫生,2016,32(6):839-841.
[4] 王晓勇,吕东岭,梁森.人参果总皂苷联合舍曲林治疗原发性高血压合并抑郁症的临床观察[J].安徽医药,2016,20(8):1557-1559,1560.
[5] 钟海兰,卢新政,孙海,等.文拉法辛对高血压伴抑郁症患者外周血干细胞因子和炎性因子表达的影响[J].江苏医药,2014,40(16):1902-1905.
[6] 马晓英,赵晓玲,金明磊,等.合并抑郁症的高血压患者不同药物治疗效果[J].中国老年学杂志,2014,34(22):6475-6476.
[7] 李海聪,李求兵,杨毅玲,等.抗抑郁治疗对老年高血压合并抑郁障碍患者血压的影响[J].中华老年心脑血管病杂志,2016,18(2):143-148.
[8] 刘东升,韩海莉,张军.非洛地平缓释片(Ⅱ)对比硝苯地平缓释片控制围绝经期高血压患者血压晨峰现象的临床观察[J].中国药房,2018,29(21):2976-2979.
[9] 李健.卡托普利联合非洛地平治疗原发性高血压的临床疗效观察[J].实用心脑肺血管病杂志,2014,22(4):10-11.
[10] 隗建鑫.非洛地平缓释片联合天麻钩藤颗粒治疗高血压64例[J].中国药业,2014,23(20):111-112.
[11] 张兵倩,王明.艾司西酞普与非洛地平联合治疗高血压合并抑郁的效果观察[J].中国现代医生,2016,54(35):93-96.
[12] 卢转娣,王要有.不同剂量艾司西酞普兰联合氯沙坦对高血压合并抑郁患者的疗效观察[J].安徽医学,2016,37(6):687-689.
[13] 许巧玲,袁泽刚,田祥,等.联用草酸艾司西酞普兰与降压药治疗高血压合并抑郁疗效观察[J].中国急救医学,2016,36(z1):79-80.
[14] 于妍,杜启峰,张建龙,等.难治性抑郁症的临床特征与血清甲状腺激素相关性研究[J].中华行为医学与脑科学杂志,2014,23(11):989-992.
[15] 刘玉娇,周洪海,王承敏,等.甲状腺激素及抗体与抑郁症的相关性[J].神经疾病与精神卫生,2015,15(4):368-371.
[2] 陈健.运动疗法在高血压合并抑郁症患者中的干预性研究[J].中国医学创新,2016,13(15):103-105.
[3] 刘晓峥,陈勤.西酞普兰联合降压药治疗原发性高血压伴焦虑抑郁患者疗效观察[J].现代医药卫生,2016,32(6):839-841.
[4] 王晓勇,吕东岭,梁森.人参果总皂苷联合舍曲林治疗原发性高血压合并抑郁症的临床观察[J].安徽医药,2016,20(8):1557-1559,1560.
[5] 钟海兰,卢新政,孙海,等.文拉法辛对高血压伴抑郁症患者外周血干细胞因子和炎性因子表达的影响[J].江苏医药,2014,40(16):1902-1905.
[6] 马晓英,赵晓玲,金明磊,等.合并抑郁症的高血压患者不同药物治疗效果[J].中国老年学杂志,2014,34(22):6475-6476.
[7] 李海聪,李求兵,杨毅玲,等.抗抑郁治疗对老年高血压合并抑郁障碍患者血压的影响[J].中华老年心脑血管病杂志,2016,18(2):143-148.
[8] 刘东升,韩海莉,张军.非洛地平缓释片(Ⅱ)对比硝苯地平缓释片控制围绝经期高血压患者血压晨峰现象的临床观察[J].中国药房,2018,29(21):2976-2979.
[9] 李健.卡托普利联合非洛地平治疗原发性高血压的临床疗效观察[J].实用心脑肺血管病杂志,2014,22(4):10-11.
[10] 隗建鑫.非洛地平缓释片联合天麻钩藤颗粒治疗高血压64例[J].中国药业,2014,23(20):111-112.
[11] 张兵倩,王明.艾司西酞普与非洛地平联合治疗高血压合并抑郁的效果观察[J].中国现代医生,2016,54(35):93-96.
[12] 卢转娣,王要有.不同剂量艾司西酞普兰联合氯沙坦对高血压合并抑郁患者的疗效观察[J].安徽医学,2016,37(6):687-689.
[13] 许巧玲,袁泽刚,田祥,等.联用草酸艾司西酞普兰与降压药治疗高血压合并抑郁疗效观察[J].中国急救医学,2016,36(z1):79-80.
[14] 于妍,杜启峰,张建龙,等.难治性抑郁症的临床特征与血清甲状腺激素相关性研究[J].中华行为医学与脑科学杂志,2014,23(11):989-992.
[15] 刘玉娇,周洪海,王承敏,等.甲状腺激素及抗体与抑郁症的相关性[J].神经疾病与精神卫生,2015,15(4):368-371.