PI3K抑制剂对正常人外周血单个核细胞糖皮质激素抵抗的作用
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摘要
<正>慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是以气流受限为特征的全身慢性进行性疾病,炎症是重要的发病机制之一,糖皮质激素作为一种有效的抗炎药物,在炎症性疾病的治疗中起着至关重要的作用,但由于COPD患者体内存在糖皮质激素抵抗,使激素对COPD慢性炎症的疗效较差[1]。有研究显示氧化应激可激活炎症细胞的磷脂酰肌醇3-激酶(phosphoinositide-3-kinase,PI3K)信
引文
[1]孙雪皎,钟小宁,何志义,等.慢性阻塞性肺疾病患者外周血单个和细胞糖皮质激素抵抗的体外观察[J].细胞与分子免疫学杂志,2013,29(5):535-537.
[2]Wada H,Takizawa H.Future treatment for COPD:targeting oxidative stress and its related signal[J].Recent Pat Inflamm Allergy Drug Discov,2013,7(1):1-11.
[3]Wu JP,Wu Q,Sun X,et al.Corticosteroid resistance in chronic obstructive pulmonary diease:new uses of theophylline[J].Chin Med J(Engl),2013,126(5):965-970.
[4]Yang SR,Chida AS,Bauter MR,et al.Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages[J].Am J Physiol Lung Cel l Mol Physio1,2006,291(1):L46-L57.
[5]NakamuraY,Romberger DJ,Tate L,et al.Cigarette smoke inhibits lung fibroblast proliferation and chemotaxis[J].Am J Respir Crit Care Med,1995,151(5):1497-1503.
[6]Culpitt SV,Rogers DF,Shah P,et al.Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2003,167(1):24-31.
[7]Barnes PJ.Glucocorticosteroids:current and future directions[J].Br J Pharmacol,2011,163(1):29-43.
[8]Adenuga D,Yao H,March TH,et al.Histone deacetylase 2 is phosphorylated,ubiquitinated,and degraded by cigarette smoke[J].Am J Repir Cell Mol Biol,2009,40(4):464-473.
[9]Mostefai HA,Agouni A,Carusio N,et al.Phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen spiecies production by apoptotic lymphocyte microparticles in endothelial cells[J].J Immunol,2008,180(7):5028-5035.
[10]Mercado N,To Y,Ito K,et al.Nortriptyline reverses corticosteroid insensitivity by of phosphoinositide-3-kinase-δ[J].J Pharmacol Exp Ther,2011,337(2):465-470.
[11]Marwick JA,Caramori G,Stevenson CS,et al.Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice[J].Am J Respir Crit Care Med,2009,179(7):542-548.
[12]Kobayashi Y,Wada H,Rossios C,et al.A novel macrolide/fluoroketolide,solithromycin(CEM-101),reversescorticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition[J].Br J Pharmacol,2013,169(5):1024-1034.
[13]Kobayashi Y,Mercado N,Miller-Larsson A,et al.Increased corticosteroid sensitivity by a long acting b2 agonist formoterol via b2adrenoceptor independent protein phosphatase 2A activation[J].Pulm Pharmacol Ther,2012,25(3):201-207.
[14]To Y,Ito K,Kizama Y,et al.Targeting phosphoinositide-3-kinasedelta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary diease[J].Am J Respir Crit Care Med,2010,182(7):897-904.
[15]Kao TC,Wu CH,Yen GC.Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1,CRE and NFAT activation[J].Phytomedicine,2013,20(3-4):295-302.
[2]Wada H,Takizawa H.Future treatment for COPD:targeting oxidative stress and its related signal[J].Recent Pat Inflamm Allergy Drug Discov,2013,7(1):1-11.
[3]Wu JP,Wu Q,Sun X,et al.Corticosteroid resistance in chronic obstructive pulmonary diease:new uses of theophylline[J].Chin Med J(Engl),2013,126(5):965-970.
[4]Yang SR,Chida AS,Bauter MR,et al.Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages[J].Am J Physiol Lung Cel l Mol Physio1,2006,291(1):L46-L57.
[5]NakamuraY,Romberger DJ,Tate L,et al.Cigarette smoke inhibits lung fibroblast proliferation and chemotaxis[J].Am J Respir Crit Care Med,1995,151(5):1497-1503.
[6]Culpitt SV,Rogers DF,Shah P,et al.Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease[J].Am J Respir Crit Care Med,2003,167(1):24-31.
[7]Barnes PJ.Glucocorticosteroids:current and future directions[J].Br J Pharmacol,2011,163(1):29-43.
[8]Adenuga D,Yao H,March TH,et al.Histone deacetylase 2 is phosphorylated,ubiquitinated,and degraded by cigarette smoke[J].Am J Repir Cell Mol Biol,2009,40(4):464-473.
[9]Mostefai HA,Agouni A,Carusio N,et al.Phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen spiecies production by apoptotic lymphocyte microparticles in endothelial cells[J].J Immunol,2008,180(7):5028-5035.
[10]Mercado N,To Y,Ito K,et al.Nortriptyline reverses corticosteroid insensitivity by of phosphoinositide-3-kinase-δ[J].J Pharmacol Exp Ther,2011,337(2):465-470.
[11]Marwick JA,Caramori G,Stevenson CS,et al.Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice[J].Am J Respir Crit Care Med,2009,179(7):542-548.
[12]Kobayashi Y,Wada H,Rossios C,et al.A novel macrolide/fluoroketolide,solithromycin(CEM-101),reversescorticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition[J].Br J Pharmacol,2013,169(5):1024-1034.
[13]Kobayashi Y,Mercado N,Miller-Larsson A,et al.Increased corticosteroid sensitivity by a long acting b2 agonist formoterol via b2adrenoceptor independent protein phosphatase 2A activation[J].Pulm Pharmacol Ther,2012,25(3):201-207.
[14]To Y,Ito K,Kizama Y,et al.Targeting phosphoinositide-3-kinasedelta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary diease[J].Am J Respir Crit Care Med,2010,182(7):897-904.
[15]Kao TC,Wu CH,Yen GC.Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1,CRE and NFAT activation[J].Phytomedicine,2013,20(3-4):295-302.