2015-2017年北京市顺义区疑似预防接种异常反应监测数据分析
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摘要
目的分析2015-2017年北京市顺义区疑似预防接种异常反应(AEFI)发生特征,评价预防接种异常反应监测系统运转情况,为改善AEFI监测工作提供参考。方法收集2015-2017年顺义区AEFI监测系统报告的个案数据,用描述性流行病学方法对相关指标进行分析。结果 2015-2017年顺义区共接种疫苗1 576 926剂次,报告AEFI 582例,报告发生率为36.91/10万,其中严重AEFI报告1例,报告发生率为0.06/10万。AEFI 24 h内报告率为100%,24 h内调查率为100%,街乡覆盖率为100%。AEFI诊断分类中一般反应495例,报告发生率为32.30/10万;异常反应81例,报告发生率为5.14/10万。AEFI报告发生率前三位的疫苗分别为DTaP-IPV-Hib五联疫苗、23价肺炎疫苗、Hib疫苗,报告发生率分别为291.32/10万、127.26/10万和123.46/10万。AEFI报告男女性别比为1.36∶1,≤1岁儿童占75.77%,集中发生在4-9月。接种≤1 d发生的占91.41%。结论顺义区AEFI监测系统运转正常,目前所使用的疫苗安全性和预防接种服务质量良好,AEFI补偿政策的出台对于AEFI监测工作具有积极作用。
Objective To analyze the epidemiological characters of adverse events following immunization(AEFI) in Shunyi district of Beijing during 2015-2017 and evaluate the implementation of AEFI surveillance system, provide the reference for improving AEFI monitoring. Methods The data of AEFIs in Shunyi district during 2015-2017 were analyzed by descriptively epidemiological method. Results A total of 1 576 926 doses of vaccines were inoculated in Shunyi district during 2015-2017, and 582 cases of AEFIs were reported, the rate of reporting incidence was 36.91/100 000. 1 case of severe AEFI was reported and the rate of reporting incidence was 0.06/100 000. The proportion of cases reported within 24 h was 100.00%, while that investigated within 24 h was 100.00%, and the coverage rate in towns was 100.00%. A total of 495 cases of general adverse reactions were reported, the rate of reporting incidence was 32.30/100 000. 81 cases of paradoxical reaction were reported, the rate of reporting incidence was 5.14/100 000. The incidence rates of AEFI caused by DTaP-IPV/Hib、23 price pneumonia vaccine and Hib were higher than those caused by other vaccines, the rate of reporting incidence were 291.32/100 000, 127.26/100 000 and 123.46/100 000, respectively. Gender ratio was 1.36∶1. 75.77% cases occurred in age group less than 1 year. Most of cases were reported from April to September. 91.41% cases of the AEFIs occurred within one day after vaccination. Conclusions The quality of AEFI surveillance system in Shunyi district worked well in general, the current vaccine safety and vaccination services are of good quality. Relevant compensation policy plays active roles in monitoring of AEFIs.
Objective To analyze the epidemiological characters of adverse events following immunization(AEFI) in Shunyi district of Beijing during 2015-2017 and evaluate the implementation of AEFI surveillance system, provide the reference for improving AEFI monitoring. Methods The data of AEFIs in Shunyi district during 2015-2017 were analyzed by descriptively epidemiological method. Results A total of 1 576 926 doses of vaccines were inoculated in Shunyi district during 2015-2017, and 582 cases of AEFIs were reported, the rate of reporting incidence was 36.91/100 000. 1 case of severe AEFI was reported and the rate of reporting incidence was 0.06/100 000. The proportion of cases reported within 24 h was 100.00%, while that investigated within 24 h was 100.00%, and the coverage rate in towns was 100.00%. A total of 495 cases of general adverse reactions were reported, the rate of reporting incidence was 32.30/100 000. 81 cases of paradoxical reaction were reported, the rate of reporting incidence was 5.14/100 000. The incidence rates of AEFI caused by DTaP-IPV/Hib、23 price pneumonia vaccine and Hib were higher than those caused by other vaccines, the rate of reporting incidence were 291.32/100 000, 127.26/100 000 and 123.46/100 000, respectively. Gender ratio was 1.36∶1. 75.77% cases occurred in age group less than 1 year. Most of cases were reported from April to September. 91.41% cases of the AEFIs occurred within one day after vaccination. Conclusions The quality of AEFI surveillance system in Shunyi district worked well in general, the current vaccine safety and vaccination services are of good quality. Relevant compensation policy plays active roles in monitoring of AEFIs.
引文
[1] WHO and WPRO.Immunization safety surveillance:guidelines for immunization program managers on surveillance of adverse events following immunization(Second Edition)[S].Manila:Philippines,2013.
[2] 国家卫生部,食品药品监督管理局.全国疑似预防接种异常反应监测方案[S].中国疫苗和免疫,2011,17(1):72-81.
[3] 张向阳,汪萍,王维维.黄山市2010-2013年疑似预防接种异常反应监测分析[J].中国生物制品学杂志,2015,28(2):155-159.
[4] 叶加楷,李克莉,许涤沙,等.中国2014年疑似预防接种异常反应信息管理系统监测数据分析[J].中国疫苗和免疫,2016,22(2):125-137.
[5] 林宝妮,方琼,曹丽,等.深圳市福田区2009-2011年疑似预防接种异常反应监测分析[J].中华疾病控制杂志,2013,17(4):346-348.
[6] 陈艳军,徐邵和,曲帅征,等.鞍山市2009-2013年疑似预防接种异常反应监测分析[J].中国公共卫生,2015,31(2):252-254.
[7] 孙美平,顾凯辰,苗良,等.2011年北京市疑似预防接种异常反应监测系统运行质量评价与报告病例分析[J].药物不良反应杂志,2012,14(6):345-350.
[8] VAN WALRAVEN C,MUSSELMAN R.The surgical site infection risk score (SSIRS):A model to predict the risk of surgical site infections[J].PLoS One,2013,8(6):e67167.DOI:10.1371/journal.pone.0067167.
[9] 李书华,赵明江,王兆良,等.湖北省2010年疑似预防接种异常反应监测分析[J].公共卫生与预防医学,2011,22(6):9-18.
[2] 国家卫生部,食品药品监督管理局.全国疑似预防接种异常反应监测方案[S].中国疫苗和免疫,2011,17(1):72-81.
[3] 张向阳,汪萍,王维维.黄山市2010-2013年疑似预防接种异常反应监测分析[J].中国生物制品学杂志,2015,28(2):155-159.
[4] 叶加楷,李克莉,许涤沙,等.中国2014年疑似预防接种异常反应信息管理系统监测数据分析[J].中国疫苗和免疫,2016,22(2):125-137.
[5] 林宝妮,方琼,曹丽,等.深圳市福田区2009-2011年疑似预防接种异常反应监测分析[J].中华疾病控制杂志,2013,17(4):346-348.
[6] 陈艳军,徐邵和,曲帅征,等.鞍山市2009-2013年疑似预防接种异常反应监测分析[J].中国公共卫生,2015,31(2):252-254.
[7] 孙美平,顾凯辰,苗良,等.2011年北京市疑似预防接种异常反应监测系统运行质量评价与报告病例分析[J].药物不良反应杂志,2012,14(6):345-350.
[8] VAN WALRAVEN C,MUSSELMAN R.The surgical site infection risk score (SSIRS):A model to predict the risk of surgical site infections[J].PLoS One,2013,8(6):e67167.DOI:10.1371/journal.pone.0067167.
[9] 李书华,赵明江,王兆良,等.湖北省2010年疑似预防接种异常反应监测分析[J].公共卫生与预防医学,2011,22(6):9-18.