MYC retards cancer cell migration through suppressing fibronectin expression
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摘要
<正>The oncoprotein MYC is a transcription factor that regulates a range of genes involved in various biological processes including cell cycle arrest, cell proliferation, metabolism, protein synthesis and genomic instability. Recently, MYC has been shown playing a role in regulating cancer cell metastasis, while outcomes of this regulation remain controversial. In some breast tumors, MYC
引文
[1] Ma L, Young J, Prabhala H, et al. miR-9, a MYC/MYCN-activated microRNA,regulates E-cadherin and cancer metastasis. Nat Cell Biol 2010;12:247–56.
[2] Waikel RL, Kawachi Y, Waikel PA, et al. Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet 2001;28:165–8.
[3] Liu H, Radisky DC, Yang D, et al. MYC suppresses cancer metastasis by direct transcriptional silencing of alphav and beta3 integrin subunits. Nat Cell Biol2012;14:567–74.
[4] Cappellen D, Schlange T, Bauer M, et al. Novel c-MYC target genes mediate differential effects on cell proliferation and migration. EMBO Rep 2007;8:70–6.
[5] Ma X, Huang J, Tian Y, et al. Myc suppresses tumor invasion and cell migration by inhibiting JNK signaling. Oncogene 2017;36:3159–67.
[6] Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 2004;5:816–26.
[7] Hood JD, Cheresh DA. Role of integrins in cell invasion and migration. Nat Rev Cancer 2002;2:91–100.
[8] Li T, Kon N, Jiang L, et al. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell 2012;149:1269–83.
[9] Pankov R, Yamada KM. Fibronectin at a glance. J Cell Sci 2002;115:3861–3.
[10] Grinnell F. Fibronectin and wound healing. J Cell Biochem 1984;26:107–16.
[11] Valenick LV, Hsia HC, Schwarzbauer JE. Fibronectin fragmentation promotes alpha4beta1 integrin-mediated contraction of a fibrin-fibronectin provisional matrix. Exp Cell Res 2005;309:48–55.
[12] Grinnell F, Billingham RE, Burgess L. Distribution of fibronectin during wound healing in vivo. J Invest Dermatol 1981;76:181–9.
[13] Han S, Khuri FR, Roman J. Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways. Cancer Res 2006;66:315–23.
[2] Waikel RL, Kawachi Y, Waikel PA, et al. Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet 2001;28:165–8.
[3] Liu H, Radisky DC, Yang D, et al. MYC suppresses cancer metastasis by direct transcriptional silencing of alphav and beta3 integrin subunits. Nat Cell Biol2012;14:567–74.
[4] Cappellen D, Schlange T, Bauer M, et al. Novel c-MYC target genes mediate differential effects on cell proliferation and migration. EMBO Rep 2007;8:70–6.
[5] Ma X, Huang J, Tian Y, et al. Myc suppresses tumor invasion and cell migration by inhibiting JNK signaling. Oncogene 2017;36:3159–67.
[6] Guo W, Giancotti FG. Integrin signalling during tumour progression. Nat Rev Mol Cell Biol 2004;5:816–26.
[7] Hood JD, Cheresh DA. Role of integrins in cell invasion and migration. Nat Rev Cancer 2002;2:91–100.
[8] Li T, Kon N, Jiang L, et al. Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence. Cell 2012;149:1269–83.
[9] Pankov R, Yamada KM. Fibronectin at a glance. J Cell Sci 2002;115:3861–3.
[10] Grinnell F. Fibronectin and wound healing. J Cell Biochem 1984;26:107–16.
[11] Valenick LV, Hsia HC, Schwarzbauer JE. Fibronectin fragmentation promotes alpha4beta1 integrin-mediated contraction of a fibrin-fibronectin provisional matrix. Exp Cell Res 2005;309:48–55.
[12] Grinnell F, Billingham RE, Burgess L. Distribution of fibronectin during wound healing in vivo. J Invest Dermatol 1981;76:181–9.
[13] Han S, Khuri FR, Roman J. Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways. Cancer Res 2006;66:315–23.