药物与食疗联合治疗儿童缺铁性贫血的效果
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摘要
目的探讨药物与食疗联合治疗儿童缺铁性贫血(IDA)的治疗效果。方法选取2014年6月~2016年6月我院收治的IDA患儿63例作为研究对象,依家长意愿将其分为治疗组(32例)与对照组(31例)。治疗组患儿在补充铁基础上结合饮食干预和治疗,对照组患儿采用常规铁治疗。分析IDA患儿的病因,比较两组患儿的各项临床表现指标、实验室检查指标以及临床疗效。结果本研究的63例IDA患儿中,<1岁、1~3岁、>3岁患儿及不同性别例数比较,差异均无统计学意义(P>0.05)。63例IDA患儿中农村儿童占63.5%,城市儿童占36.5%,母乳喂养但未及时添加辅食者占66.7%,人工喂养和混合喂养者分别占15.9%和17.4%,患儿的居住所在地、喂养类型比较,差异有统计学意义(P<0.05)。两组患儿的各项临床表现指标(包括病程>3个月、面色苍白、食欲缺乏、肝大、脾大)比较,差异无统计学意义(P>0.05)。治疗后,治疗组患儿的Hb、MCHC、MCV、MCH和SF均高于对照组,差异有统计学意义(P<0.05)。治疗组患儿的治疗总有效率(96.9%)高于对照组(67.7%),差异有统计学意义(P<0.05)。结论 IDA好发婴幼儿中,农村儿童发病比例多于城市儿童,母乳喂养但未及时添加辅食者患病比例高于人工喂养、混合喂养者。小剂量铁剂与膳食治疗联合的方案效果好。
Objective To investigate clinical treatment effect of drug therapy and dietary therapy in children with irondeficiency anemia.Methods A total of 63 children with iron-deficiency anemia who treated in our hospital from June2014 to June 2016 were divided into treatment group(n=32) and controlled group(n=31) according to the parents′ will.The treatment group was supplemented with iron on the basis of diet intervention,the control group was received conventional iron treatment.The etiology of IDA children was analyzed and the clinical manifestations,laboratory test indexes and clinical efficacy of children in the two groups were compared.Results In the 63 children with IDA of this study,the children at the age of < 1 year old,1-3 years old and >3 years old and different gender were compared,the difference were not statistically significant(P>0.05).In the 63 children with IDA,the rural children accounted for 63.5%,children in the big cities accounted for 36.5%,breast-feeding without supplement on time accounted for 66.7%,artificial feeding and mixed feeding accounted for 15.9% and 17.4% respectively,the children′ s home areas and feeding type were compared,the differences were statistically significant(P<0.05).The clinical indicators of two groups of children(including course >3 months,pale complexion,appetite decreases,hepatomegaly,splenomegaly) were compared,the differences were not statistically significant(P>0.05).After treatment,the Hb,MCHC,MCV,MCH and SF in the treatment group were higher than those in the control group,and the differences were statistically significant(P<0.05).The total clinical effective rate of treatment group(96.9%) was higher than that of control group(67.7%),and the difference was statistically significant(P<0.05).Conclusion IDA is more prevalent in infants and children living in rural.Infants with breast-feeding without supplement are at higher risk for IDA.The children with small dose of iron combination of food are good therapeutic effect.
Objective To investigate clinical treatment effect of drug therapy and dietary therapy in children with irondeficiency anemia.Methods A total of 63 children with iron-deficiency anemia who treated in our hospital from June2014 to June 2016 were divided into treatment group(n=32) and controlled group(n=31) according to the parents′ will.The treatment group was supplemented with iron on the basis of diet intervention,the control group was received conventional iron treatment.The etiology of IDA children was analyzed and the clinical manifestations,laboratory test indexes and clinical efficacy of children in the two groups were compared.Results In the 63 children with IDA of this study,the children at the age of < 1 year old,1-3 years old and >3 years old and different gender were compared,the difference were not statistically significant(P>0.05).In the 63 children with IDA,the rural children accounted for 63.5%,children in the big cities accounted for 36.5%,breast-feeding without supplement on time accounted for 66.7%,artificial feeding and mixed feeding accounted for 15.9% and 17.4% respectively,the children′ s home areas and feeding type were compared,the differences were statistically significant(P<0.05).The clinical indicators of two groups of children(including course >3 months,pale complexion,appetite decreases,hepatomegaly,splenomegaly) were compared,the differences were not statistically significant(P>0.05).After treatment,the Hb,MCHC,MCV,MCH and SF in the treatment group were higher than those in the control group,and the differences were statistically significant(P<0.05).The total clinical effective rate of treatment group(96.9%) was higher than that of control group(67.7%),and the difference was statistically significant(P<0.05).Conclusion IDA is more prevalent in infants and children living in rural.Infants with breast-feeding without supplement are at higher risk for IDA.The children with small dose of iron combination of food are good therapeutic effect.
引文
[1]张强,范歆,何升,等.儿童地中海贫血复合缺铁性贫血表型及临床[J].中国小儿血液与肿瘤杂志,2015,20(1):14-16.
[2]吴颖,黄淑红.儿童缺铁性贫血的治疗及临床分析[J].中国现代药物应用,2015,9(12):163-164.
[3]沈晓明,王卫平.儿科学[M].7版.北京:人民卫生出版社,2008,349.
[4]齐共健.140例儿童缺铁性贫血的疗效分析[J].中外妇儿健康,2011,19(9):126-127.
[5]中华人民共和国卫生部.儿童营养性疾病管理技术规范[J].中国儿童保健杂志,2012,20(11):1052-1054.
[6]《中华儿科杂志》编辑委员会,中华医学会儿科学分会血液学组,中华医学会儿科学分会儿童保健学组,等.儿童缺铁和缺铁性贫血防治建议[J].中华儿科杂志,2008,46(7):502-504.
[7]努尔古丽.吾拉孜霍加,古娜娜·托列提别克.新疆伊犁哈萨克族儿童缺铁性贫血住院患儿临床分析[J].系统医学,2016,1(8):88-90.
[8]章昌敏.小儿缺铁性贫血78例临床分析[J].中国现代药,2016,1(16):49-51.
[9]张彦春,武明辉.婴儿缺铁性贫血的研究进展[J].中国妇幼保健,2017,32(8):1806-1808.
[10]杨冬华.婴儿营养性缺铁性贫血的影响因素分析和防治措施探析[J].中国现代药物应用,2016,10(16):89-90.
[11]Qasem WA,Friel JK.An overview of iron in term breastfed infants[J].Clin Med Insights Pediatr,2015,6(9):79-84.
[12]赵玮婷,傅弦琴,杜兆辉.社区儿保婴幼儿营养性缺铁性贫血筛查与高危因素分析[J].中国初级卫生保健,2015,29(12):36-38.
[13]徐康,张翠梅,黄连红,等.6~12月龄婴儿缺铁性贫血的危险因素分析及对神经心理发育的影响[J].中国当代儿科杂志,2015,17(8):830-836.
[14]黄中炎,陈勇,孙佳,等.1658例婴幼儿缺铁性贫血调查分析[J].中国妇幼保健,2015,30(2):266-269.
[15]Menon KC,Ferguson EL,Thomson CD,et al.Effects of anemia at different stages of gestation on infant outcomes[J].Nutrition,2016,32(1):61-65.
[2]吴颖,黄淑红.儿童缺铁性贫血的治疗及临床分析[J].中国现代药物应用,2015,9(12):163-164.
[3]沈晓明,王卫平.儿科学[M].7版.北京:人民卫生出版社,2008,349.
[4]齐共健.140例儿童缺铁性贫血的疗效分析[J].中外妇儿健康,2011,19(9):126-127.
[5]中华人民共和国卫生部.儿童营养性疾病管理技术规范[J].中国儿童保健杂志,2012,20(11):1052-1054.
[6]《中华儿科杂志》编辑委员会,中华医学会儿科学分会血液学组,中华医学会儿科学分会儿童保健学组,等.儿童缺铁和缺铁性贫血防治建议[J].中华儿科杂志,2008,46(7):502-504.
[7]努尔古丽.吾拉孜霍加,古娜娜·托列提别克.新疆伊犁哈萨克族儿童缺铁性贫血住院患儿临床分析[J].系统医学,2016,1(8):88-90.
[8]章昌敏.小儿缺铁性贫血78例临床分析[J].中国现代药,2016,1(16):49-51.
[9]张彦春,武明辉.婴儿缺铁性贫血的研究进展[J].中国妇幼保健,2017,32(8):1806-1808.
[10]杨冬华.婴儿营养性缺铁性贫血的影响因素分析和防治措施探析[J].中国现代药物应用,2016,10(16):89-90.
[11]Qasem WA,Friel JK.An overview of iron in term breastfed infants[J].Clin Med Insights Pediatr,2015,6(9):79-84.
[12]赵玮婷,傅弦琴,杜兆辉.社区儿保婴幼儿营养性缺铁性贫血筛查与高危因素分析[J].中国初级卫生保健,2015,29(12):36-38.
[13]徐康,张翠梅,黄连红,等.6~12月龄婴儿缺铁性贫血的危险因素分析及对神经心理发育的影响[J].中国当代儿科杂志,2015,17(8):830-836.
[14]黄中炎,陈勇,孙佳,等.1658例婴幼儿缺铁性贫血调查分析[J].中国妇幼保健,2015,30(2):266-269.
[15]Menon KC,Ferguson EL,Thomson CD,et al.Effects of anemia at different stages of gestation on infant outcomes[J].Nutrition,2016,32(1):61-65.