摘要
目的对无柄灵芝Ganodermaresinaceum子实体的化学成分进行研究,以期发现新的化合物。方法利用硅胶、MCI-GEL树脂及PR-HPLC等多种色谱技术进行分离纯化,并根据理化性质和波谱数据鉴定化合物的结构。结果从云南瑞丽产无柄灵芝子实体中分离得到4个化合物,分别鉴定为无柄灵芝素F(1)、3β,7β,15β-三羟基-11,23-二酮基-羊毛脂-8,16-二烯-26-羧酸(2)、灵芝酸XL_2(3)和2,3-二氢-4(1H)-喹诺酮(4)。结论其中化合物1为1个新的杂萜类成分,命名为无柄灵芝素F。
Objective For the purpose of finding new agents, the chemical study on Ganoderma resinaceum was carried out. Methods The chemical constituents from the dried fruiting bodies of G. resinaceum were isolated by column chromatographic methods of silica gel, MCI-Gel resin, and high performance liquid chromatography. The structures were elucidated by spectroscopic methods, including extensive 1 D and 2 D NMR techniques. Results Four compounds including one new meroterpenoid were isolated from this fungus. Their structures were identified as ganoresinains F(1), 3β,7β,15β-trihydroxy-11,23-dioxo-lanost-8,16-dien-26-oic acid(2), ganoderic acid XL_2(3) and 2,3-dihydro-4(1 H)-quinolone(4). Conclusion Compound 1 is a new compound and named as ganoresinains F(1).
引文
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