丹红注射液对糖尿病足患者下肢动脉血液动力学的影响
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摘要
目的探讨丹红注射液治疗糖尿病足的临床疗效观察。方法选取我院内分泌科糖尿病足0～2级的患者66例。分为治疗组和对照组各33例。治疗组给予丹红注射液,对照组给予银杏叶注射液,疗程4周,以双下肢动脉B超分别对两组组内治疗前后和两组组间治疗后的血管内径、收缩期峰值流速、血流量进行比较分析。结果两组双侧腘动脉,胫后动脉,足背动脉治疗后比治疗前的血管内径均增加,峰值流速下降,血流量增加,差异均有统计学意义(P<0.01)。治疗组双侧腘动脉,胫后动脉,足背动脉的血管内径和血流量在治疗后增加的差值均较对照组明显,差异均有统计学意义(P<0.01)。结论丹红注射液在治疗糖尿病足患者下肢动脉血管内径和血流量增加方面的疗效均优于银杏叶,更值得临床推广。
Objective To explore the clinical effects of danhong injection on diabetic foot. Methods A total of66 patients of diabetic foot of 0 to 2 grades were collected from the Department of Endocrinology of the Hospital and divided into a treatment group and a control group,33 cases in each one. In the treatment group,danhong injection was used. In the control group,the ginkgo leaf injection was given. The duration of treatment was 4 weeks. The ultrasonic B test on the arteries of the lower extremities was adopted for the comparison and analysis on the intravascular diameter,the systolic peak velocity and blood flow in the inter-group before and after treatment and intra-group after treatment. Results For the bilateral popliteal arteries,the posterior tibial arteries and foot dorsal arteries,the intravascular diameter was increased,the peat velocity reduced and blood flow increased after treatment as compared with those before treatment in the two groups,indicating the significant differences( P < 0. 01). In the treatment group,for the bilateral popliteal arteries,the posterior tibial arteries and foot dorsal arteries,the increased values of intravascular diameter and blood flow after treatment were obvious as compared with those before treatment,indicating the significant difference( P < 0. 01). Conclusion The therapeutic effects of danhong injection are better than the ginkgo leaf injection for increasing intravascular diameter and blood flow of the arteries in the lower extremities. Hence,this injection deserves greatly to be promoted in clinical treatment.
Objective To explore the clinical effects of danhong injection on diabetic foot. Methods A total of66 patients of diabetic foot of 0 to 2 grades were collected from the Department of Endocrinology of the Hospital and divided into a treatment group and a control group,33 cases in each one. In the treatment group,danhong injection was used. In the control group,the ginkgo leaf injection was given. The duration of treatment was 4 weeks. The ultrasonic B test on the arteries of the lower extremities was adopted for the comparison and analysis on the intravascular diameter,the systolic peak velocity and blood flow in the inter-group before and after treatment and intra-group after treatment. Results For the bilateral popliteal arteries,the posterior tibial arteries and foot dorsal arteries,the intravascular diameter was increased,the peat velocity reduced and blood flow increased after treatment as compared with those before treatment in the two groups,indicating the significant differences( P < 0. 01). In the treatment group,for the bilateral popliteal arteries,the posterior tibial arteries and foot dorsal arteries,the increased values of intravascular diameter and blood flow after treatment were obvious as compared with those before treatment,indicating the significant difference( P < 0. 01). Conclusion The therapeutic effects of danhong injection are better than the ginkgo leaf injection for increasing intravascular diameter and blood flow of the arteries in the lower extremities. Hence,this injection deserves greatly to be promoted in clinical treatment.
引文
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[4]庄梅,杨俊杰.糖尿病足早期下肢动静脉血管变化及中药治疗研究[J].按摩与康复医学,2015,6(4):123-124.
[5]李津凯,张秀军.前列地尔联合舒血宁治疗早期糖尿病足的疗效观察[J].天津医学,2015,27(3):36-38.
[6]庞雅玲,蒋淑琰.阿加曲班联合葛根素治疗糖尿病动脉硬化闭塞症疗效观察[J].现代中西医结合杂志,2016,25(16):1766-1767.
[7]蔺虹,张媛华.丹红注射液对脑梗死患者血脂及血液流变学的影响[J].云南中医中药杂志,2007,28(6):20-21.
[8]刘会卿,王冬玉.丹红注射液治疗2型糖尿病患者下肢血管病变疗效观察[J].临床合理用药,2011,4(11B):50.
[9]张立.舒血宁制剂药理研究进展[J].中国中医基础医学杂志,2000,6(9):68-69.
[10]何雄文,牛美兰.活血生肌汤对糖尿病足末梢循环的干预作用[J].中国老年学杂志,2017,2(37):629-630.
[11]王建立.银杏叶提取物改善血液流变学及临床应用的研夯进展[J].世界临床药物,2006,27(10):604-611.
[2]Wagner FW Jr.The dysvascular foot:a system for diagnosis and treatment[J].Foot Ankle,1981,2(2):64-122.
[3]中华医学会糖尿病学分会.中国2型糖尿病防治指南(2013年版)[J].中华糖尿病杂志,2014,6(7):447-498.
[4]庄梅,杨俊杰.糖尿病足早期下肢动静脉血管变化及中药治疗研究[J].按摩与康复医学,2015,6(4):123-124.
[5]李津凯,张秀军.前列地尔联合舒血宁治疗早期糖尿病足的疗效观察[J].天津医学,2015,27(3):36-38.
[6]庞雅玲,蒋淑琰.阿加曲班联合葛根素治疗糖尿病动脉硬化闭塞症疗效观察[J].现代中西医结合杂志,2016,25(16):1766-1767.
[7]蔺虹,张媛华.丹红注射液对脑梗死患者血脂及血液流变学的影响[J].云南中医中药杂志,2007,28(6):20-21.
[8]刘会卿,王冬玉.丹红注射液治疗2型糖尿病患者下肢血管病变疗效观察[J].临床合理用药,2011,4(11B):50.
[9]张立.舒血宁制剂药理研究进展[J].中国中医基础医学杂志,2000,6(9):68-69.
[10]何雄文,牛美兰.活血生肌汤对糖尿病足末梢循环的干预作用[J].中国老年学杂志,2017,2(37):629-630.
[11]王建立.银杏叶提取物改善血液流变学及临床应用的研夯进展[J].世界临床药物,2006,27(10):604-611.