HPLC法分析不同来源的红曲原料
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摘要
红曲是利用传统的固体发酵工艺而得到的天然产品,已成为目前保健食品中具有辅助降血脂功能产品的最重要原料,其安全性得到了广泛关注。采用不同的分析方法对不同厂家的功能性红曲米原料进行了检测,发现不同厂家的红曲原料中洛伐他汀的含量不尽相同,而且其原料的副产物也各不相同。但目前国家对红曲的副产物没有管理规范,因此消费者在选择红曲类保健食品时,尤其是长期服用红曲产品的消费者,应十分慎重。
Red fermented rice is a natural product obtained by traditional solid-state fermentation,the dietary supplement which are mainly composed of red fermented rice have occupied the biggest market share of natural products with auxiliary antihyperlipidemic action,the safety of red fermented rice has been garnered a lot of attention. Red fermented rice which come from different manufacturers were analyzed by different analytic procedures,the results showed the content of lovastatin and the varieties of by-components were different. Consumers should be very careful when they buy the dietary supplement of red fermented rice.
Red fermented rice is a natural product obtained by traditional solid-state fermentation,the dietary supplement which are mainly composed of red fermented rice have occupied the biggest market share of natural products with auxiliary antihyperlipidemic action,the safety of red fermented rice has been garnered a lot of attention. Red fermented rice which come from different manufacturers were analyzed by different analytic procedures,the results showed the content of lovastatin and the varieties of by-components were different. Consumers should be very careful when they buy the dietary supplement of red fermented rice.
引文
[1]李东,刘源,谢静,等.红曲的起源、分类学及生药学鉴定[J].中国药业,2009,18(3):1-2.
[2]邢旺兴,宓鹤鸣,贺祥.红曲考证[J].中药材,2000,23(3):175-177.
[3]Endo A,Monacolin K.A new hypocholesterolemic agent produced by a Monascus species[J].J.Antibiotics,1979,32:852-854.
[4]Juzlova P,Martinkova L,Kren V.Secondary metabolites of the fungus Monascus:a review[J].J Ind Microbiol,1996,16:163-170.
[5]陈平,罗金亮,周礼红.红曲代谢产物的研究现状和前景[J].酿造与检测,2009,26(4):26-29.
[6]Lin Y L,Wang T H,Lee M H,et al.Biologically active components and nutraceuticals in the Monascus fermented rice:a review[J].Appl Microbiol Biotechnol,2008,77:965-973.
[7]文镜,刘迪,金宗濂.洛伐他汀检测方法研究进展[J].北京联合大学学报(自然科学版),2003,17(3):70-74.
[8]谢静,李东,王敏,等.HPLC法测定血脂康胶囊中洛伐他汀的含量[J].中国药房,2010,21(45):4287-4289.
[9]国家药典委员会.中华人民共和国药典[M].北京.中国医药科技出版社,2010.
[10]段震文,马学敏,郭树仁.一种红曲药材的质量检测方法:中国ZL200610145837.0[P].2009-02-04.
[11]宋洪涛,实鹤鸣,郭涛,等.HPLC法对不同来源红曲中洛伐他汀的定量分析[J].中草药,1999,30(2):100-102.
[12]葛锋,王艳,王剑平,等.红曲中主要活性成分的研究[J].昆明理工大学学报(自然科学版),2012,37(2):61-64.
[2]邢旺兴,宓鹤鸣,贺祥.红曲考证[J].中药材,2000,23(3):175-177.
[3]Endo A,Monacolin K.A new hypocholesterolemic agent produced by a Monascus species[J].J.Antibiotics,1979,32:852-854.
[4]Juzlova P,Martinkova L,Kren V.Secondary metabolites of the fungus Monascus:a review[J].J Ind Microbiol,1996,16:163-170.
[5]陈平,罗金亮,周礼红.红曲代谢产物的研究现状和前景[J].酿造与检测,2009,26(4):26-29.
[6]Lin Y L,Wang T H,Lee M H,et al.Biologically active components and nutraceuticals in the Monascus fermented rice:a review[J].Appl Microbiol Biotechnol,2008,77:965-973.
[7]文镜,刘迪,金宗濂.洛伐他汀检测方法研究进展[J].北京联合大学学报(自然科学版),2003,17(3):70-74.
[8]谢静,李东,王敏,等.HPLC法测定血脂康胶囊中洛伐他汀的含量[J].中国药房,2010,21(45):4287-4289.
[9]国家药典委员会.中华人民共和国药典[M].北京.中国医药科技出版社,2010.
[10]段震文,马学敏,郭树仁.一种红曲药材的质量检测方法:中国ZL200610145837.0[P].2009-02-04.
[11]宋洪涛,实鹤鸣,郭涛,等.HPLC法对不同来源红曲中洛伐他汀的定量分析[J].中草药,1999,30(2):100-102.
[12]葛锋,王艳,王剑平,等.红曲中主要活性成分的研究[J].昆明理工大学学报(自然科学版),2012,37(2):61-64.