血管紧张素Ⅱ 1型受体基因多态性对动脉硬化影响的Meta分析
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摘要
目的研究血管紧张素Ⅱ1型受体基因(AGTR1) A1166C多态性对动脉硬化的影响。方法以脉搏波传导速度(PWV)为评价动脉硬化的指标。在Pub Med、EMBASE、Cochrane Library和Web of Science中检索与主题相关的英文文章。检索时限为建库至2018年10月。2位作者根据相应的纳入和排除标准独立选择合适的观察性研究。采用Revman 5. 2软件和STATA 11. 0软件进行Meta分析。结果共有7篇文章被纳入分析(n=1 687)。分析结果显示,在总体人群和白种人群中,AGTR1 A1166C多态性与PWV没有显著相关性;在亚洲人群中,等位基因C携带者的PWV显著高于AA基因型(AC+CC比AA:SMD=0. 33,95%CI 0. 06～0. 60,P=0. 02)。结论AGTR1 A1166C多态性可能与亚洲人的动脉硬化相关。等位基因C可能是亚洲人群PWV升高的危险因素。
Aim To study the effect of A1166 C polymorphism of angiotensin Ⅱ type 1 receptor gene( AGTR1 on arteriosclerosis. Methods Pulse wave velocity( PWV) was chosen as an index for evaluating arteriosclerosis.Topic-related English literatures were searched in Pub Med,EMBASE,Cochrane Library and Web of Science. The retrieval time was from the establishment of the database to October 2018. Two authors independently selected appropriate observational studies based on the corresponding inclusion and exclusion criteria. Revman 5. 2 software and STATA 11. 0 software were used for Meta-analysis. Results A total of seven literatures( n = 1 687) was included in the Meta-analysis. The results showed that there was no significant correlation between AGTR1 A1166 C polymorphism and PWV in general population and white population. In Asian population,the PWV of allele C carriers was significantly higher than that of AA genotype( AC+CC vs AA: SMD = 0. 33,95% CI 0. 06-0. 60,P = 0. 02). Conclusions AGTR1 A1166 C polymorphism may be associated with arteriosclerosis in Asians. Allele C may be a risk factor for PWV elevation in Asian population.
Aim To study the effect of A1166 C polymorphism of angiotensin Ⅱ type 1 receptor gene( AGTR1 on arteriosclerosis. Methods Pulse wave velocity( PWV) was chosen as an index for evaluating arteriosclerosis.Topic-related English literatures were searched in Pub Med,EMBASE,Cochrane Library and Web of Science. The retrieval time was from the establishment of the database to October 2018. Two authors independently selected appropriate observational studies based on the corresponding inclusion and exclusion criteria. Revman 5. 2 software and STATA 11. 0 software were used for Meta-analysis. Results A total of seven literatures( n = 1 687) was included in the Meta-analysis. The results showed that there was no significant correlation between AGTR1 A1166 C polymorphism and PWV in general population and white population. In Asian population,the PWV of allele C carriers was significantly higher than that of AA genotype( AC+CC vs AA: SMD = 0. 33,95% CI 0. 06-0. 60,P = 0. 02). Conclusions AGTR1 A1166 C polymorphism may be associated with arteriosclerosis in Asians. Allele C may be a risk factor for PWV elevation in Asian population.
引文
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[14]Lajemi M,Labat C,Gautier S,et al. Angiotensin II type1 receptor-153A/G and 1166A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjects[J]. J Hypertens,2001,19(3):407-413.
[15]Benetos A,Gautier S,Ricard S,et al. Influence of angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms on aortic stiffness in normotensive and hypertensive patients[J]. Circulation,1996,94(4):698-703.
[16]陈贻珊,李俊平,孔振兴,等.动脉硬化对成年人心脏结构、功能及运动变化特征的影响[J].中国动脉硬化杂志,2018,26(11):1140-1146.
[17]Cwynar M,Gasowski J,Gluszewska A,et al. Blood pressure,arterial stiffness and endogenous lithium clearance in relation to AGTR1 A1166C and AGTR2 G1675A gene polymorphisms[J]. J Renin Angiotensin Aldosterone Syst,2016,17(2):1607587787.
[18] Martin M,Buckenberger A,Jiang J,et al. The human angiotensin II type 1 receptor+1166 A/C polymorphism attenuates microRNA-155 binding[J]. J Biol Chem,2007,282(33):24262-24269.
[19]Goncharova L,Postnov AY,Sergutova NP. The estimation of the vascular status parameters,depending on the gene polymorphism carrier of the angiotensin II receptor type 1considering the ethnicity of patients with AH[J]. Eur Heart J,2014,35:369.
[20] Konopka A,Szperl M,Piotrowski W,et al. Polymorphisms of angiotensin II type 1 receptor gene and those of angiotensinogen point at culprit artery in ST-segment elevation myocardial infarction[J]. Gene,2012,500(1):148-150.
[21]Zhang JA,Li JR,Qiao YJ. Association of AGTR1 gene A1166C polymorphism with the risk of heart failure:a meta-analysis[J]. Genet Mol Res, 2015, 14(3):9163-9170.
[22]Wen W,Luo R,Tang X,et al. Age-related progression of arterial stiffness and its elevated positive association with blood pressure in healthy people[J]. Atherosclerosis,2015,238(1):147-152.
[2]Liu W,Zhou J,Chen J,et al. Ambulatory arterial stiffness index and its role in assessing arterial stiffness in dialysis patients[J]. J Hypertens,2017,35(6):1297-1301.
[3]Saiki A,Sato Y,Watanabe R,et al. The role of a novel arterial stiffness parameter, cardio-ankle vascular index(CAVI),as a surrogate marker for cardiovascular diseases[J]. J Atheroscler Thromb,2016,23(2):155-168.
[4]Logan JG,Engler MB,Kim H. Genetic determinants of arterial stiffness[J]. J Cardiovasc Transl Res,2015,8(1):23-43.
[5]Aroor AR,Demarco VG,Jia G,et al. The role of tissue renin-angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness[J]. Front Endocrinol(Lausanne),2013,4:161.
[6]潘绍义,李利华,张雷,等.血管紧张素Ⅱ1型受体A1166C多态与血压的关系[J].中国动脉硬化杂志,2013,21(7):623-626.
[7]曾宪涛,刘慧,陈曦,等. Meta分析系列之四:观察性研究的质量评价工具[J].中国循证心血管医学杂志,2012,4(4):297-299.
[8]Zeng X,Zhang Y,Kwong JS,et al. The methodological quality assessment tools for preclinical and clinical studies,systematic review and meta-analysis,and clinical practice guideline:a systematic review[J]. J Evid Based Med,2015,8(1):2-10.
[9]Gardier S,Vincent M,Lantelme P,et al. A1166C polymorphism of angiotensin II type 1 receptor,blood pressure and arterial stiffness in hypertension[J]. J Hypertens,2004,22(11):2135-2142.
[10]Benetos A,Giron A,Joly L,et al. Influence of the AGTR1A1166C genotype on the progression of arterial stiffness:A 16-year longitudinal study[J]. Am J Hypertens,2013,26(12):1421-1427.
[11]Lee JA,Sohn JA,Hong YM. Polymorphism of the angiotensin II type 1 receptor A1166C in Korean hypertensive adolescents[J]. Korean Circ J,2008,38(8):405-410.
[12]Mayer OJ,Filipovsky J,Pesta M,et al. Synergistic effect of angiotensin II type 1 receptor and endothelial nitric oxide synthase gene polymorphisms on arterial stiffness[J].J Hum Hypertens,2008,22(2):111-118.
[13]Rehman A,Rasool AH,Naing L,et al. Influence of the angiotensin II type I receptor gene 1166A>C polymorphism on BP and aortic pulse wave velocity among Malays[J].Ann Hum Genet,2007,71(Pt 1):86-95.
[14]Lajemi M,Labat C,Gautier S,et al. Angiotensin II type1 receptor-153A/G and 1166A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjects[J]. J Hypertens,2001,19(3):407-413.
[15]Benetos A,Gautier S,Ricard S,et al. Influence of angiotensin-converting enzyme and angiotensin II type 1 receptor gene polymorphisms on aortic stiffness in normotensive and hypertensive patients[J]. Circulation,1996,94(4):698-703.
[16]陈贻珊,李俊平,孔振兴,等.动脉硬化对成年人心脏结构、功能及运动变化特征的影响[J].中国动脉硬化杂志,2018,26(11):1140-1146.
[17]Cwynar M,Gasowski J,Gluszewska A,et al. Blood pressure,arterial stiffness and endogenous lithium clearance in relation to AGTR1 A1166C and AGTR2 G1675A gene polymorphisms[J]. J Renin Angiotensin Aldosterone Syst,2016,17(2):1607587787.
[18] Martin M,Buckenberger A,Jiang J,et al. The human angiotensin II type 1 receptor+1166 A/C polymorphism attenuates microRNA-155 binding[J]. J Biol Chem,2007,282(33):24262-24269.
[19]Goncharova L,Postnov AY,Sergutova NP. The estimation of the vascular status parameters,depending on the gene polymorphism carrier of the angiotensin II receptor type 1considering the ethnicity of patients with AH[J]. Eur Heart J,2014,35:369.
[20] Konopka A,Szperl M,Piotrowski W,et al. Polymorphisms of angiotensin II type 1 receptor gene and those of angiotensinogen point at culprit artery in ST-segment elevation myocardial infarction[J]. Gene,2012,500(1):148-150.
[21]Zhang JA,Li JR,Qiao YJ. Association of AGTR1 gene A1166C polymorphism with the risk of heart failure:a meta-analysis[J]. Genet Mol Res, 2015, 14(3):9163-9170.
[22]Wen W,Luo R,Tang X,et al. Age-related progression of arterial stiffness and its elevated positive association with blood pressure in healthy people[J]. Atherosclerosis,2015,238(1):147-152.