莫西沙星治疗对耐药肺结核患者血清对氧磷酶活性、PCT水平及生活质量的影响分析

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英文篇名：Effect analysis of moxifloxacin on serum paraoxonase activity, PCT level and life quality on patients with drug-resistant pulmonary tuberculosis 作者：张瑾麟 ; 马世伟 ; 薛庆亮 ; 苏瑞雪 英文作者：ZHANG Jinlin;MA Shiwei;XUE Qingliang;SU Ruixue;Department of Immunization, Center for Disease Control and Prevention in Chengguan District of Lanzhou City;Center for Disease Control and Prevention in Chengguan District of Lanzhou City;Department of Respiratory, the 940th of Joint Logistics Support Force of the Chinese People′s Liberation Army;Department of Anesthesiology, Pulmonary Hospital of Lanzhou; 关键词：莫西沙星 ; 耐药肺结核 ; 氧磷酶活性 ; 血清降钙素原 ; 治疗 英文关键词：Moxifloxacin;;Drug-resistant tuberculosis;;Paraoxonase activity;;Serum procalcitonin;;Treatment 中文刊名：NKYT 英文刊名：Internal Medicine 机构：兰州市城关区疾病预防控制中心免疫规划科;兰州市城关区疾病预防控制中心;解放军联勤保障部队940医院呼吸内科;兰州市肺科医院麻醉科; 出版日期：2019-06-25 出版单位：内科 年：2019 期：v.14 语种：中文; 页：NKYT201903015 页数：4 CN：03 ISSN：45-1347/R 分类号：45-47+50

摘要

目的探讨莫西沙星治疗对耐药肺结核患者血清对氧磷酶1(PON1)活性、降钙素原(PCT)水平以及生活质量的影响。方法选取2018年1～12月我院收治的耐药肺结核患者78例为研究对象,采用随机数字表法分为两组。对照组患者39例,接受常规化疗;观察组39例,在常规化疗的基础上接受莫西沙星治疗。比较两组患者的PON1活性、PCT水平以及生活质量。结果治疗18个月后,观察组患者的PON1活性明显高于对照组,血清PCT水平明显低于对照组,差异有统计学意义(P<0.05)。观察组患者的生活质量评分明显高于对照组,差异有统计学意义(P<0.05)。结论莫西沙星治疗能够提高耐药肺结核患者血清PONI活性,降低血清PCT水平,改善患者生活质量。
        Objective To investigate the effect of moxifloxacin on serum paraoxonase 1(PON1) activity, procalcitonin(PCT) levels and life quality on patients with drug-resistant pulmonary tuberculosis. Methods A total of 78 patients with drug-resistant tuberculosis admitted to our hospital from January 2018 to December 2018 were enrolled and randomly divided into two groups. The control group(39 cases) received conventional chemotherapy and the observation group(39 cases) received moxifloxacin on the basis of conventional chemotherapy. PON1 activity, PCT levels and life quality were compared between the two groups. Results After 18 months of treatment, the observation group had significantly higher PON1 activity and life quality score as well as lower serum PCT level in comparison with the control group, and the difference was statistically significant(P<0.05). Conclusion Moxifloxacin treatment can improve the PON1 activity on patients with drug-resistant tuberculosis, reduce serum PCT levels and improve their life quality.

引文

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