饱和水溶液法制备莫能菌素-β-环糊精包合物的研究
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摘要
为研究莫能菌素包合物的制备工艺,以β-环糊精为包合材料,采用饱和水溶液法制备莫能菌素β-环糊精包合物。用红外光谱法(IR)对包合物进行物相鉴定。以包合率为指标,运用正交设计法,确定最佳处方和工艺条件。IR结果表明,药物与环糊精形成了包合物。当投料比为3∶1,包合温度为40℃,搅拌时间1.5h时,该制备工艺最佳,包合率为57.54%。该制备工艺可行,扩大了莫能菌素的应用,为莫能菌素的剂型改进奠定了基础。
To study the preparation technology of inclusion compound carrying monensin,monensin was encapsulated withβ-cyclodextrin using saturated water solution.The phase identification of inclusion compound was examed by infra-red spectrum(IR).Based on a comprehensive evaluation of inclusion efficiency,the optimal formulation and process conditions of inclusion compound carrying monensin were determined by orthogonal design methods.IR result showed that inclusion compound carrying monensin was formed;The best optimum of the preparation technology were as follows:The proportion of the quality ofβ-cyclodextrin and monensin was3∶1,the temperature of inclusion was 40 ℃,and the time of inclusion was 1.5h.The inclusion rate was 57.54%.This preparation technology was feasible,and enlarged the use of monensin.The study laid a foundation for improvement about dosage form of monensin.
To study the preparation technology of inclusion compound carrying monensin,monensin was encapsulated withβ-cyclodextrin using saturated water solution.The phase identification of inclusion compound was examed by infra-red spectrum(IR).Based on a comprehensive evaluation of inclusion efficiency,the optimal formulation and process conditions of inclusion compound carrying monensin were determined by orthogonal design methods.IR result showed that inclusion compound carrying monensin was formed;The best optimum of the preparation technology were as follows:The proportion of the quality ofβ-cyclodextrin and monensin was3∶1,the temperature of inclusion was 40 ℃,and the time of inclusion was 1.5h.The inclusion rate was 57.54%.This preparation technology was feasible,and enlarged the use of monensin.The study laid a foundation for improvement about dosage form of monensin.
引文
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[2]杨娜,曾明华,吴丽君,等.三种抗球虫药对鸡球虫病的对比疗效[J].中国兽药杂志,2012,46(2):16-18.
[3]宁豫昌,陈忠杰,郭宏伟,等.莫能菌素的应用现状[J].郑州牧业工程高等专科学校学报,2007,27(3):21.
[4]隋世慧,胡兰.莫能菌素的研究概况及其应用[J].现代畜牧兽医,2013,2:52-55.
[5]杨晓燕,赵补军,国卫杰.莫能菌素在牛生产中的应用[J].新疆畜牧业,2011,z1:4-5.
[6]李峰,赵永星.兽药新剂型与新技术的应用与发展[J].北方牧业,2012,45(1):52-55.
[7]Dan W,Li H,Gu J,et al.Ternary system of dihydroartemisinin with hydroxypropyl-β-cyclodextrin and lecithin:Simultaneous enhancement of drug solubility and stability in aqueous solutions[J].Journal of Pharmaceutical&Biomedical Analysis,2013,83(83):141-148.
[8]廖才智.β-环糊精的应用研究进展[J].化工科技,2010,18(5):69-72.
[9]何爱明,范景鹏,林世明.阿司匹林-β-环糊精包合物的制备工艺优选[J].福建师大福清分校学报,2010,5:35-41.
[10]王慧竹,陈帅,常琳,等.阿司匹林-β-环糊精包合物的制备工艺优化研究[J].吉林化工学院学报,2012,29(9):55-58.
[11]尤思路,高秀蓉,廖昌军.饱和水溶液法制备葛根素-β-环糊精包合物研究[J].西南军医,2008,10(4):17-19.
[12]牛江秀,张小伟,张春雨.饱和水溶液法制备盐酸奈福泮-β-环糊精包合物工艺[J].黄山学院学报,2015,17(5):48-52.
[13]李振,高振珅,龙君江.盐酸沙拉沙星-β-环糊精包合物的制备[J].西北农林科技大学学报:自然科学版,2013,3:50-54.
[14]Xi J,Qian D,Duan J,et al.Preparation,characterization and pharmacokinetic study of Xiangfu Siwu decoction essential oil/β-cyclodextrin inclusion complex[J].Molecules,2015,20(6):10705-10720.
[15]张兴德,郁红礼,周玲玲,等.正交法筛选莪术油微球制备工艺[J].南京中医药大学学报(自然科学版),2007,23(5):304-306.
[16]崔福德,龙晓英.药剂学[M].第7版.北京:人民卫生出版社,2013.
[17]沈海民,纪红兵,武宏科,等.β-环糊精的固载及其应用最新研究进展[J].有机化学,2014,34(8):1549-1572.
[18]北京市华都峪口禽业有限责任公司.家禽常见药物新用法、用量介绍[J].北方牧业,2011,2:26.
[19]杨晋辉,周凌云,赵芸君,等.反刍动物抗生素替代物的研究进展[J].中国畜牧兽医,2011,38(7):162-167.