枸橼酸他莫昔芬片治疗乳腺囊性增生症的临床疗效观察
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摘要
目的探讨枸缘酸他莫昔芬片在治疗乳腺囊性增生症中的临床疗效。方法选取在本院接受治疗的乳腺囊性增生患者88例作为研究对象,对患者进行编号,并将其随机分为对照组与观察组,对照组应用乳癖消治疗,观察组应用枸缘酸他莫昔芬片治疗,对比分析两组患者临床治疗效果与不良反应情况。结果对照组患者临床治疗总有效率与不良反应率分别为68.18%、6.81%,观察组患者临床治疗总有效率与不良反应率分别为95.45%、11.36%,在临床疗效比较差异具有统计学意义(P<0.05),在不良反应率方面观察组虽高于对照组,但差异无统计学意义。结论应用枸缘酸他莫昔芬片治疗乳腺囊性增生症临床疗效显著,但不良反应率相对较多,临床用药应根据患者情况选择。
Objective To investigate the clinical efficacy of tamoxifen sputum in the treatment of cystic hyperplasia of the breast. Methods Eightyeight patients with cystic hyperplasia of the breast who were treated in our hospital were selected as the study subjects. The patients were numbered and randomly divided into the control group and the observation group. The control group was treated with chylomicron. The treatment of tamoxifen rimmed tablets was used to compare the clinical treatment effects and adverse reactions of the two groups. Results The total effective rate and adverse reaction rate of the control group were 68.18% and 6.81%, respectively. The total effective rate and adverse reaction rate of the observation group were 95.45% and 11.36%, respectively. The difference in clinical efficacy was statistically significant(P<0.05), and the adverse reaction rate in the observation group was higher than that in the control group, but the difference was not statistically significant. Conclusion The clinical efficacy of tamoxifen sputum in the treatment of cystic hyperplasia of the breast is significant, but the adverse reaction rate is relatively high. The clinical medication should be selected according to the patient' s condition.
Objective To investigate the clinical efficacy of tamoxifen sputum in the treatment of cystic hyperplasia of the breast. Methods Eightyeight patients with cystic hyperplasia of the breast who were treated in our hospital were selected as the study subjects. The patients were numbered and randomly divided into the control group and the observation group. The control group was treated with chylomicron. The treatment of tamoxifen rimmed tablets was used to compare the clinical treatment effects and adverse reactions of the two groups. Results The total effective rate and adverse reaction rate of the control group were 68.18% and 6.81%, respectively. The total effective rate and adverse reaction rate of the observation group were 95.45% and 11.36%, respectively. The difference in clinical efficacy was statistically significant(P<0.05), and the adverse reaction rate in the observation group was higher than that in the control group, but the difference was not statistically significant. Conclusion The clinical efficacy of tamoxifen sputum in the treatment of cystic hyperplasia of the breast is significant, but the adverse reaction rate is relatively high. The clinical medication should be selected according to the patient' s condition.
引文
[1]陈凯.中西医结合治疗乳腺囊性增生症和乳痛症4370例[J].医药论坛杂志,2003,23(17):22-23,25.
[2]李秀楠.鹿鳖汤治疗乳腺囊性增生症56例临床观察[J].浙江中医学院学报,2004,27(3):29.
[3]赵凯华,颜政,宫磊,等.象限切除法治疗重度乳腺囊性增生症伴乳房下垂[J].现代肿瘤医学,2014,21(10):2340-2342.
[4]王颖,陈飞,孙鹤庆,等.乳腺囊性增生症与大汗腺在临床上的相关性分析[J].世界临床医学,2017,11(13):52.
[5]韩晶,全红,严伟国,等.乳晕双环切口治疗乳腺囊性增生症伴乳房下垂[J].中华乳腺病杂志,2012,5(6):657-663.
[6]王丽芳,陈正连.中西医结合治疗乳腺囊性增生症141例疗效观察与护理[J].时珍国医国药,1999,9(4):Ⅵ.
[7]郭宇飞,吕娟,王书勤.岩鹿乳康胶囊对乳腺增生大鼠乳腺组织及雌孕激素受体表达的影响[J].中国现代医学杂志,2017,26(13):14-18.
[8]卢强.他莫昔芬与托瑞米芬治疗复发或转移性乳腺癌的临床对比研究[J].当代医学,2011,17(26):128-129.
[9]张琳,林红.早期乳腺癌患者术后应用托瑞米芬和他莫昔芬的对比研究[J].当代医学,2010,16(16):36-37.
[2]李秀楠.鹿鳖汤治疗乳腺囊性增生症56例临床观察[J].浙江中医学院学报,2004,27(3):29.
[3]赵凯华,颜政,宫磊,等.象限切除法治疗重度乳腺囊性增生症伴乳房下垂[J].现代肿瘤医学,2014,21(10):2340-2342.
[4]王颖,陈飞,孙鹤庆,等.乳腺囊性增生症与大汗腺在临床上的相关性分析[J].世界临床医学,2017,11(13):52.
[5]韩晶,全红,严伟国,等.乳晕双环切口治疗乳腺囊性增生症伴乳房下垂[J].中华乳腺病杂志,2012,5(6):657-663.
[6]王丽芳,陈正连.中西医结合治疗乳腺囊性增生症141例疗效观察与护理[J].时珍国医国药,1999,9(4):Ⅵ.
[7]郭宇飞,吕娟,王书勤.岩鹿乳康胶囊对乳腺增生大鼠乳腺组织及雌孕激素受体表达的影响[J].中国现代医学杂志,2017,26(13):14-18.
[8]卢强.他莫昔芬与托瑞米芬治疗复发或转移性乳腺癌的临床对比研究[J].当代医学,2011,17(26):128-129.
[9]张琳,林红.早期乳腺癌患者术后应用托瑞米芬和他莫昔芬的对比研究[J].当代医学,2010,16(16):36-37.