利培酮不同给药频率治疗精神分裂症的临床疗效
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摘要
目的探讨利培酮不同服药频率治疗精神分裂症的临床疗效。方法选取重庆市九龙坡区精神卫生中心2016年1—6月收治的首发精神分裂症患者72例,采用随机数字表法分为一次组37例和两次组35例。一次组患者给药频率为1次/晚,中午投用外观相同的安慰剂。两次组患者给药频率为2次/d,两组患者均持续治疗8周。比较两组患者的临床疗效,阳性症状评分、阴性症状评分、精神病理评分及阳性与阴性症状量表(PANSS)总分,不良反应发生情况及用药剂量。结果两组患者治疗总有效率、阳性症状评分、阴性症状评分、精神病理评分及PANSS总分比较,差异无统计学意义(P>0.05)。两组患者不良反应发生率、用药剂量及TESS评分比较,差异无统计学意义(P>0.05)。结论利培酮不同服药频率治疗精神分裂症的临床疗效相当,且不会增加不良反应,而一次给药方式有助于提高患者服药依从性。
Objective To evaluate the clinical effect of different dose-frequency of risperidone on schizophrenia.Methods A total of 72 cases of schizophrenia patients were selected from January to June in 2016 in Jiulongpo Mental Health Center of Chongqing,which were divided into once-daily dosing group(n=37) and twice-daily dosing group(n=35) according to random number table.Once-daily dosing group was given once per night,and given placebo with the same appearance at the noon.Twice-daily dosing group was given twice per day,both groups were treated for 8 weeks.The clinical effect,positive symptom score,negative symptom score,psychopathology score and PANSS score,the incidence of adverse reactions and medicine doses were compared between the two groups.Results No statistically significant differences of total efficiency rate,positive symptom score,negative symptom score,psychopathology score or PANSS score was found between the two groups(P>0.05).No statistically significant differences of the incidence of adverse reactions or medicine doses was found between the two groups(P>0.05).Conclusion Different dose-frequency of risperidone have an same clincial effect on schizophrenia,and will not increase adverse reactions,but once-daily dosing is benefit for the compliance of patients with medication.
Objective To evaluate the clinical effect of different dose-frequency of risperidone on schizophrenia.Methods A total of 72 cases of schizophrenia patients were selected from January to June in 2016 in Jiulongpo Mental Health Center of Chongqing,which were divided into once-daily dosing group(n=37) and twice-daily dosing group(n=35) according to random number table.Once-daily dosing group was given once per night,and given placebo with the same appearance at the noon.Twice-daily dosing group was given twice per day,both groups were treated for 8 weeks.The clinical effect,positive symptom score,negative symptom score,psychopathology score and PANSS score,the incidence of adverse reactions and medicine doses were compared between the two groups.Results No statistically significant differences of total efficiency rate,positive symptom score,negative symptom score,psychopathology score or PANSS score was found between the two groups(P>0.05).No statistically significant differences of the incidence of adverse reactions or medicine doses was found between the two groups(P>0.05).Conclusion Different dose-frequency of risperidone have an same clincial effect on schizophrenia,and will not increase adverse reactions,but once-daily dosing is benefit for the compliance of patients with medication.
引文
[1]张庭青.利培酮治疗康复期精神分裂症的疗效及认知功能和情感障碍与精神症状关系的研究[J].临床合理用药杂志,2015,8(9):68-69.
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[7]Agarwal V,Chadda RK.Once daily risperidone in treatment of schizophrenia[J].Indian Journal of Psychiatry,2001,43(1):32-35.
[8]Takeuchi H,Fervaha G,Lee J,et al.Effectiveness of different dosing regimens of risperidone and olanzapine in schizophrenia[J].European Neuropsychopharmacology the Journal of the European College of Neuropsychopharmacology,2015,25(3):295-302.
[2]Jauhar S,Guloksuz S,Andlauer O,et al.Choice of antipsychotic treatment by European psychiatry trainees:are decisions based on evidence?[J].BMC Psychiatry,2012,12(1):1-8.
[3]赵晶媛,黄光彪,顾小静.4种第二代抗精神病药物治疗精神分裂症急性期的临床观察[J].药物与临床,2016,27(20):2790-2794.
[4]Correll CU,Ca1as F,Larmo I,et al.Individualizing antipsychotic treatment selection in schizophrenia:characteristics of empirically derived patient subgroups[J].European Psychiatry,2011,26(1):3-16.
[5]Patteet L,Morrens M,Maudens KE,et al.Therapeutic drug monitoring of common antipsychotics[J].Therapeutic Drug Monitoring,2012,34(6):629-651.
[6]赵靖平,施慎逊.中国精神分裂症防治指南[M].北京:中华医学电子音像出版社,2015:57.
[7]Agarwal V,Chadda RK.Once daily risperidone in treatment of schizophrenia[J].Indian Journal of Psychiatry,2001,43(1):32-35.
[8]Takeuchi H,Fervaha G,Lee J,et al.Effectiveness of different dosing regimens of risperidone and olanzapine in schizophrenia[J].European Neuropsychopharmacology the Journal of the European College of Neuropsychopharmacology,2015,25(3):295-302.