血清孕酮联合β-HCG、TSH检测对早期妊娠结局的预测意义
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摘要
目的探讨血清孕酮(P)、血β-人绒毛膜促性腺激素(β-HCG)、促甲状腺激素(TSH)联合检测在预测早期妊娠结局中的临床价值。方法回顾性分析2013年12月~2015年5月在山西医学科学院就诊的100例正常妊娠患者(正常妊娠组)、80例继续妊娠患者(继续妊娠组)和80例难免流产患者(难免流产组),采用美国贝克曼公司的DXI800化学发光免疫分析仪及配套试剂测定三组患者血清中的P、β-HCG、TSH值。结果 P、β-HCG、TSH的受试者工作特征曲线(ROC)下面积分别为0.702、0.776、0.468,联合检测的ROC曲线下面积为0.999。血清P、β-HCG、TSH预测活胎与难免流产的cut-off值分别为12.90 ng/ml、10 258 m IU/ml、2.5 m IU/L。将各项激素的cut-off值设定为临界值,得出难免流产组的P、β-HCG水平显著低于正常妊娠组和继续妊娠组,阳性率高于正常妊娠组和继续妊娠组,TSH水平和阳性率均显著高于正常妊娠组和继续妊娠组(P均<0.05);3项激素中,β-HCG的阳性率(68.00%)最高;P、β-HCG、TSH联合检测的灵敏度为68.75%,特异度为71.50%,阳性预测值为51.56%,阴性预测值为72.36%,各指标均高于单项检测(P<0.05)。结论单项激素预测早期妊娠结局的价值不高。P、β-HCG、TSH联合检测有助于提高难免流产的诊断性能和早期检出率,3项激素联合检测是预测难免流产较理想的标志物组合。
Objective To investigate the clinical value of combined detection of serum progesterone(P),blood β-human chorionic gonadotropin(β-HCG) and thyroid stimulating hormone(TSH) in the prediction of early pregnancy outcome.Methods 100 patients with normal pregnancy(normal pregnancy group),80 patients continuing pregnancy(continuing pregnancy group) and 80 patients with inevitable abortion(inevitable abortion group) treated by Shanxi Acadmey of Medical Science from December 2013 to May 2015 were retrospectively analyzed.DXI800 chemiluminescence immunoassay analyzer and supporting reagent in Beckman company of America was used to detect the serum P,β-HCG,and TSH value in three groups. Results The area under of receiver operating characteristic curve(ROC) was0.702,0.776,0.468 respectively,and the area under of ROC for combined detection was 0.999.Cut-off value of serum P,β-HCG,TSH predicting live birth and inevitable abortion was 12.90 ng/ml,102 58 m IU/ml,2.5 m IU/L respectively.Cutoff value of each hormone was set as the critical value,it showed that P and β-HCG level in inevitable abortion group was significantly lower than that of normal pregnancy group and continuing pregnancy group respectively,positive rate was higher than that of normal pregnancy group and continuing pregnancy group respectively,and TSH level and positive rate was significantly higher than that of normal pregnancy group and continuing pregnancy group respectively(all P<0.05).Among 3 kinds of hormone,positive rate of β-HCG was highest(68.00%);sensitivity was 68.75%,the specificity was 71.50%,the positive predictive value was 51.56%,the negative predictive value was 72.36% of combined detection of P,β-HCG and TSH,and each index was higher than that of single detection(P<0.05). Conclusion The value of single hormone predicting early pregnancy outcome is not high.Combined detection of P and h CG and TSH helps to improve the diagnostic performance and early detection rate of inevitable abortion.Combined detection of 3 hormone an more ideal marker combination predicting inevitable abortion.
Objective To investigate the clinical value of combined detection of serum progesterone(P),blood β-human chorionic gonadotropin(β-HCG) and thyroid stimulating hormone(TSH) in the prediction of early pregnancy outcome.Methods 100 patients with normal pregnancy(normal pregnancy group),80 patients continuing pregnancy(continuing pregnancy group) and 80 patients with inevitable abortion(inevitable abortion group) treated by Shanxi Acadmey of Medical Science from December 2013 to May 2015 were retrospectively analyzed.DXI800 chemiluminescence immunoassay analyzer and supporting reagent in Beckman company of America was used to detect the serum P,β-HCG,and TSH value in three groups. Results The area under of receiver operating characteristic curve(ROC) was0.702,0.776,0.468 respectively,and the area under of ROC for combined detection was 0.999.Cut-off value of serum P,β-HCG,TSH predicting live birth and inevitable abortion was 12.90 ng/ml,102 58 m IU/ml,2.5 m IU/L respectively.Cutoff value of each hormone was set as the critical value,it showed that P and β-HCG level in inevitable abortion group was significantly lower than that of normal pregnancy group and continuing pregnancy group respectively,positive rate was higher than that of normal pregnancy group and continuing pregnancy group respectively,and TSH level and positive rate was significantly higher than that of normal pregnancy group and continuing pregnancy group respectively(all P<0.05).Among 3 kinds of hormone,positive rate of β-HCG was highest(68.00%);sensitivity was 68.75%,the specificity was 71.50%,the positive predictive value was 51.56%,the negative predictive value was 72.36% of combined detection of P,β-HCG and TSH,and each index was higher than that of single detection(P<0.05). Conclusion The value of single hormone predicting early pregnancy outcome is not high.Combined detection of P and h CG and TSH helps to improve the diagnostic performance and early detection rate of inevitable abortion.Combined detection of 3 hormone an more ideal marker combination predicting inevitable abortion.
引文
[1]谢辛,苟文丽.妇产科学[M].8版.北京:人民卫生出版社,2013:34-35.
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[4]王文立,王亚凡,孙艳华,等.血清孕酮、促绒毛膜性腺激素水平检测与早期继续妊娠妊娠预后临床研究[J].河北医药,2007,29(12):1323-1324.
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[9]张凤兰.血清β-HCG、雌二醇和孕酮对异位妊娠的诊断意义[J].中国当代医药,2010,17(28):22-23.
[10]龚翠花.子宫内膜厚度、血清β-绒毛膜促性腺激素、雌二醇和孕酮对疑似异位妊娠的预测价值[J].中国妇幼保健,2010,25(22):3142-3143.
[11]王薇薇,单忠艳.妊娠期甲状腺疾病筛查策略[J].中国实用内科杂志,2010,30(4):386-388.
[12]中华医学会内分泌学分会《中国甲状腺疾病诊治指南》编写组.甲状腺疾病诊治指南---甲状腺功能减退症[J].中华内科杂志,2007,46(11):967-971.
[13]Shan ZY,Chen YY,Teng WP,et al.A study for maternal thyroid hormone deficiency during the first half of pregnancy in China[J].Eur J Clin Invest,2009,39(1):37-42.
[14]Dosiou C,Sanders GD,Araki SS,et al.Screening pregnant women for autoimmune thyroid disease:a cost-effectiveness analysis[J].Eur J Endocrinol,2008,158(6):841-851.
[15]Negro R,Greco G,Mangieri T,et al.The influence of selenium supplementation on postpartum thyroid status in pregnant woman with thyroid peroxidase autoantibodies[J].J Clin Endocrinol Metab,2007,92(4):1263-1268.
[2]张颖辉,钟梅.血清β绒毛膜促性腺激素、孕酮及雌二醇检测用于早期异位妊娠诊断的价值[J].中华临床医师杂志(电子版),2011,5(23):7112-7114.
[3]梁指荣,李颖嫦.血清孕酮、HCG检测在继续妊娠中的临床诊断意义[J].中国优生与遗传杂志,2007,15(1):65-67.
[4]王文立,王亚凡,孙艳华,等.血清孕酮、促绒毛膜性腺激素水平检测与早期继续妊娠妊娠预后临床研究[J].河北医药,2007,29(12):1323-1324.
[5]蒋小平.CA125、β-HCG、孕酮对早期继续妊娠结局的预测[J].中国临床医学,2013,20(2):189-190.
[6]刘霓,刘炜培,张羽虹,等.妊娠早期绒毛膜促性腺激素和孕酮的临床意义分析[J].中国优生与遗传杂志,2006,14(2):48-49.
[7]张莉.β-HCG,P,E2联合检测在早期妊娠的应用价值[J].中国优生与遗传杂志,2015,23(4):76-77.
[8]曹小秋,顾猛.孕早期血清β-HCG、E2、P联合测定及E2/P比值的临床意义[J].中华全科医学,2008,6(11):1191-1192.
[9]张凤兰.血清β-HCG、雌二醇和孕酮对异位妊娠的诊断意义[J].中国当代医药,2010,17(28):22-23.
[10]龚翠花.子宫内膜厚度、血清β-绒毛膜促性腺激素、雌二醇和孕酮对疑似异位妊娠的预测价值[J].中国妇幼保健,2010,25(22):3142-3143.
[11]王薇薇,单忠艳.妊娠期甲状腺疾病筛查策略[J].中国实用内科杂志,2010,30(4):386-388.
[12]中华医学会内分泌学分会《中国甲状腺疾病诊治指南》编写组.甲状腺疾病诊治指南---甲状腺功能减退症[J].中华内科杂志,2007,46(11):967-971.
[13]Shan ZY,Chen YY,Teng WP,et al.A study for maternal thyroid hormone deficiency during the first half of pregnancy in China[J].Eur J Clin Invest,2009,39(1):37-42.
[14]Dosiou C,Sanders GD,Araki SS,et al.Screening pregnant women for autoimmune thyroid disease:a cost-effectiveness analysis[J].Eur J Endocrinol,2008,158(6):841-851.
[15]Negro R,Greco G,Mangieri T,et al.The influence of selenium supplementation on postpartum thyroid status in pregnant woman with thyroid peroxidase autoantibodies[J].J Clin Endocrinol Metab,2007,92(4):1263-1268.