化疗联合髓白1号方治疗急性髓系白血病对Th17细胞相关细胞因子的影响
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摘要
目的探讨化疗联合髓白1号方对急性髓系白血病患者骨髓上清液白介素-6(IL-6)、转化生长因子β(TGF-β1)、白介素-23(IL-23)、白介素-17(IL-17)的影响。方法 2016年9月—2018年8月对本院住院的36例急性髓系白血病患者随机分为观察组和对照组,两组应用相同的化疗方案化疗,观察组在对照组基础上联合髓白1号方,比较两组治疗前、后的疗效及骨髓上清液IL-6、TGF-β1、IL-23、IL-17。结果 (1)治疗后实验组的完全缓解率高于对照组;(2)治疗后两组IL-6、TGF-β1、IL-23、IL-17降低,且实验组降低显著(P<0.05)。结论化疗联合髓白1号方提高缓解率,可改善急性髓系白血病患者骨髓免疫环境,可干预Th17细胞的增殖、分化的调控作用。
Objective To investigate the effects of chemotherapy combined with medullary 1 prescription on interleukin 6(IL-6),transforming growth factorβ(TGF-β),interleukin-23(IL-23)and interleukin-17(IL-17)in bone marrow supernatant of patients with acute myeloid leukemia.Methods From September 2016 to August 2018,Thirty-six patients with acute myeloid leukemia in our department were randomly divided into two groups(the observation group and the control group).Both groups were treated with the same chemotherapy,the observation group was combined with medullary 1 prescription.The curative effect and the levels of bone marrow supernatant IL-6,TGF-β,IL-23 and IL-17 were compared before and after treatment.Results(1) the rate of complete remission was higher in the experimental group than in the control group after treatment.(2) after treatment the levels of IL-6,TGF-β,IL-23 and IL-17 were decreased in the two groups,and the decrease was more obvious in the experimental group(P<0.05).Conclusion chemotherapy combined with medullary 1 prescription can improve the remission rate,improve the bone marrow immune environment and interfere the regulation of proliferation and differentiation of Th17 cells.
Objective To investigate the effects of chemotherapy combined with medullary 1 prescription on interleukin 6(IL-6),transforming growth factorβ(TGF-β),interleukin-23(IL-23)and interleukin-17(IL-17)in bone marrow supernatant of patients with acute myeloid leukemia.Methods From September 2016 to August 2018,Thirty-six patients with acute myeloid leukemia in our department were randomly divided into two groups(the observation group and the control group).Both groups were treated with the same chemotherapy,the observation group was combined with medullary 1 prescription.The curative effect and the levels of bone marrow supernatant IL-6,TGF-β,IL-23 and IL-17 were compared before and after treatment.Results(1) the rate of complete remission was higher in the experimental group than in the control group after treatment.(2) after treatment the levels of IL-6,TGF-β,IL-23 and IL-17 were decreased in the two groups,and the decrease was more obvious in the experimental group(P<0.05).Conclusion chemotherapy combined with medullary 1 prescription can improve the remission rate,improve the bone marrow immune environment and interfere the regulation of proliferation and differentiation of Th17 cells.
引文
[1]李海亮,刘礼平,赖文鸿,等.HAG方案治疗难治、复发急性非淋巴细胞白血病[J].赣南医学院学报,2012,32(1):93-94.
[2]黄建霞,张连生,等.急性白血病患者外周血Treg细胞与Th17细胞的相关性[J].中国肿瘤生物治疗杂志.2011,18(4):430-433.
[3]沈梯,赵永强.血液病诊断及疗效标准[M].第4版.北京:科学出版社,2018:87-110.
[4]Cella D,Jensen SE,Webster K,et al.Measuring health related quality of life in leukemia:the functional assessment of cancer therapy leukemia(FACT-Leu)questionnaire[J].Value Health,2012,15(8):1051-1058.
[5]苏凤哲.中医药治疗急性白血病临床探讨[J].世界中西医结合杂志.2007,2(8):435-437.
[6]陈毅宁,廖斌,皇甫真萍.复方君子汤治疗气阴两虚型急性白血病20例[J].福建中医药,2012,43(4):11-12.
[7]Lee YK,Turner H,Maynard CL,et al.Late developmental plasticity in the T helper 17 lineage[J].Immunity.2009,30(2):102-107.
[8]李全林,顾方明.辅助性T细胞17与肿瘤免疫[J].复旦学报(医学版),2010,37(4):498-501.
[9]Leslie,Guéry,Stéphanie,et al.Th17 cell plasticity and functions in cancer immunity[J].Bio Med Res Int,2015,20(8):314620.
[10]潘铭,黄建霞,王宁,等,探Th17细胞在急性髓细胞白血病中的作用[J].临床血液学杂志,2016(3):389-391.
[11]吴学忠,魏海明.Th17细胞与TGF-β1相关性的研究进展[J].细胞与分子免疫学杂志,2008,24(1):92-93.
[12]郭振兴,郑翠玲,陈振萍,等,白介素6对人Th17细胞的免疫调节作用[J].中国实验血液学杂志.2011,19(2):496-498.
[13]李敏敏,邹亚伟,彭淑梅,等.白血病患儿骨髓及分离培养MSC的IL-6水平[J].中国输血杂志,2015,28(5):549-552.
[14]Marcin Kortylewski,Hong Xin,Maciej,et al.Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment[J].Cancer cell,2009,15(2):114-123.
[2]黄建霞,张连生,等.急性白血病患者外周血Treg细胞与Th17细胞的相关性[J].中国肿瘤生物治疗杂志.2011,18(4):430-433.
[3]沈梯,赵永强.血液病诊断及疗效标准[M].第4版.北京:科学出版社,2018:87-110.
[4]Cella D,Jensen SE,Webster K,et al.Measuring health related quality of life in leukemia:the functional assessment of cancer therapy leukemia(FACT-Leu)questionnaire[J].Value Health,2012,15(8):1051-1058.
[5]苏凤哲.中医药治疗急性白血病临床探讨[J].世界中西医结合杂志.2007,2(8):435-437.
[6]陈毅宁,廖斌,皇甫真萍.复方君子汤治疗气阴两虚型急性白血病20例[J].福建中医药,2012,43(4):11-12.
[7]Lee YK,Turner H,Maynard CL,et al.Late developmental plasticity in the T helper 17 lineage[J].Immunity.2009,30(2):102-107.
[8]李全林,顾方明.辅助性T细胞17与肿瘤免疫[J].复旦学报(医学版),2010,37(4):498-501.
[9]Leslie,Guéry,Stéphanie,et al.Th17 cell plasticity and functions in cancer immunity[J].Bio Med Res Int,2015,20(8):314620.
[10]潘铭,黄建霞,王宁,等,探Th17细胞在急性髓细胞白血病中的作用[J].临床血液学杂志,2016(3):389-391.
[11]吴学忠,魏海明.Th17细胞与TGF-β1相关性的研究进展[J].细胞与分子免疫学杂志,2008,24(1):92-93.
[12]郭振兴,郑翠玲,陈振萍,等,白介素6对人Th17细胞的免疫调节作用[J].中国实验血液学杂志.2011,19(2):496-498.
[13]李敏敏,邹亚伟,彭淑梅,等.白血病患儿骨髓及分离培养MSC的IL-6水平[J].中国输血杂志,2015,28(5):549-552.
[14]Marcin Kortylewski,Hong Xin,Maciej,et al.Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment[J].Cancer cell,2009,15(2):114-123.