低强度脉冲超声波联合壮骨伸筋胶囊治疗膝骨性关节炎疗效及对关节滑液中IL-1β和VEGF水平影响
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摘要
目的探讨低强度脉冲超声波联合壮骨伸筋胶囊治疗膝骨性关节炎疗效及对关节滑液中IL-1β和VEGF水平影响。方法选择2017年5月～2018年5月在我院骨科康复门诊120例KOA患者,按采用随机数字法原则将患者随机分为对照组、观察组1、观察组2和观察组3,每组各30例;对照组给予布洛芬缓释胶囊口服,观察组1组给予低强度脉冲超声波治疗,观察组2给予壮骨伸筋胶囊口服,观察组3给予低强度脉冲超声波联合壮骨伸筋胶囊口服;比较四组疗效及关节滑液中IL-1β和VEGF浓度变化。结果四组总有效率有显著差异(χ~2=30.67,P<0.01);治疗后四组关节滑液中IL-1β和VEGF浓度差异有统计学意义(F=5.43、5.60,P<0.01)。结论低强度脉冲超声波联合壮骨伸筋胶囊能显著提高疗效,显著降低关节滑液中IL-1β和VEGF水平。
Objective To investigate the effect of low-intensity pulsed ultrasound combined with Zhuanggu Shenjin capsule on knee osteoarthritis and its effect on IL-1β and VEGF levels in synovial fluid of joint. Methods A total of120 patients with KOA in the orthopedic rehabilitation clinic in our hospital from May 2017 to May 2018 were randomly divided into control group, observation group 1, observation group 2 and observation group 3, with 30 cases in each group. The control group was given ibuprofen sustained-release capsules orally. The observation group 1 group was given low-intensity pulsed ultrasound treatment. The observation group 2 was given Zhuanggu Shenjin capsule orally. The observation group 3 was given low-intensity pulsed ultrasound treatment and Zhuanggu Shenjin capsule orally. The effects of 4 groups and the changes of IL-1β and VEGF in synovial fluid were compared. Results There were significant differences in the total effective rate between the four groups(χ~2=30.67, P<0.01). There were significant differences in the concentrations of IL-1β and VEGF in the synovial fluid between the four groups after treatment(F=5.43, 5.60, P<0.01).Conclusion Low-intensity pulsed ultrasound combined with Zhuanggu Shenjin capsule can significantly improve the efficacy and significantly reduce the levels of IL-1β and VEGF in synovial fluid.
Objective To investigate the effect of low-intensity pulsed ultrasound combined with Zhuanggu Shenjin capsule on knee osteoarthritis and its effect on IL-1β and VEGF levels in synovial fluid of joint. Methods A total of120 patients with KOA in the orthopedic rehabilitation clinic in our hospital from May 2017 to May 2018 were randomly divided into control group, observation group 1, observation group 2 and observation group 3, with 30 cases in each group. The control group was given ibuprofen sustained-release capsules orally. The observation group 1 group was given low-intensity pulsed ultrasound treatment. The observation group 2 was given Zhuanggu Shenjin capsule orally. The observation group 3 was given low-intensity pulsed ultrasound treatment and Zhuanggu Shenjin capsule orally. The effects of 4 groups and the changes of IL-1β and VEGF in synovial fluid were compared. Results There were significant differences in the total effective rate between the four groups(χ~2=30.67, P<0.01). There were significant differences in the concentrations of IL-1β and VEGF in the synovial fluid between the four groups after treatment(F=5.43, 5.60, P<0.01).Conclusion Low-intensity pulsed ultrasound combined with Zhuanggu Shenjin capsule can significantly improve the efficacy and significantly reduce the levels of IL-1β and VEGF in synovial fluid.
引文
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[6]艾金伟,李德胜,刘羽,等.中医辩证治疗膝骨性关节炎的网状Meta分析[J].中国循证医学杂志,2016,16(5):532-542.
[7]童静玲,陈雪芬,朱让腾,等.续断对兔膝骨性关节炎模型血清中IL-1β和VEGF影响的实验研究[J].中国卫生检验杂志,2015,25(19):3253-3255.
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[10]徐菲,杨克新,刘国恩,等.奇正消痛贴膏治疗骨性关节炎疼痛的药物经济学评价[J].中国全科医学,2017,20(36):4529-4533.
[11]郑洁,袁普卫.骨性关节炎的代谢机制研究进展[J].中国骨质疏松杂志,2018,24(3):406-410.
[12]聂新盼,王文波,王保新,等.骨性关节炎早期诊断方法的评价分析[J].医学综述,2012,18(14):2207-2209.
[13]裴璠,沈姗怡,刘保红.超短波治疗膝骨性关节炎作用机制研究进展[J].中国慢性病预防与控制,2018,26(7):542-545.
[14]刘新荣.超短波加运动疗法治疗膝关节骨性关节炎[J]临床医学,2016,36(7):55-56.
[15]陈文锋,黄海,申文龙.膝骨性关节炎不同中医证型与血清和关节液MMP-3、MMP-7表达的关系[J].浙江中西医结合杂志,2018,28(8):660-663.
[16]丰哲,闫腾龙,韦坚,等.韦贵康分期辨证治疗膝骨性关节炎[J].中华中医药杂志,2014,29(7):2234-2237.
[17]黄明辉,宋进良,陈彦军,等.膝关节骨性关节炎的治疗[J].医学综述,2017,23(16):3250-3260.
[18]邵洁琦,曾志江,杨敏,等.右归丸联合隔姜灸治疗阳虚寒凝型膝骨性关节炎的临床效果[J].中国医药导报,2018,15(10):106-109.
[19]张莹,朱志杰,李萍,等.壮骨伸筋胶囊的抗炎镇痛作用研究[J].中国药房,2016,27(1):35-37.
[20]白斌,李燕琴,李曙明,等.丹参对兔骨性关节炎关节软骨白介素-1β、白介素-6和胰岛素样生长因子-Ⅰ表达的影响[J].中国康复医学杂志,2015,30(10):990-994.
[21]朱让腾,童静玲,罗利飞,等.膝骨性关节炎关节滑液中OPN与VEGF的含量检测及其意义[J].中国卫生检验杂志,2014,24(21):3096-3101.
[2]Wang Y,Wluka AE,Simpson JA,et al.Body weight at early and middle adulthood,weight gain and persistent overweight from early adulthood are predictors of the risk of total knee and hip replacement for osteoarthritis[J]Rheumatology(Oxford),2013,52(6):1033-1041.
[3]杨渠平,范宁,何仁建.膝关节骨性关节炎的性别差异及相关因素[J].中国老年学杂志,2016,36(1):144-146.
[4]刘强,洪加源,胡维界.膝骨性关节炎治疗进展[J].医学综述,2015,21(3):474-476.
[5]高明霞,林强,陈安亮,等.低强度脉冲超声联合药物治疗创伤性膝关节骨性关节炎的临床研究[J].中国康复医学杂志,2016,31(8):862-867.
[6]艾金伟,李德胜,刘羽,等.中医辩证治疗膝骨性关节炎的网状Meta分析[J].中国循证医学杂志,2016,16(5):532-542.
[7]童静玲,陈雪芬,朱让腾,等.续断对兔膝骨性关节炎模型血清中IL-1β和VEGF影响的实验研究[J].中国卫生检验杂志,2015,25(19):3253-3255.
[8]中华医学会骨科学分会.骨关节炎诊治指南(2007年版)[J].中国临床医生杂志,2008,36(1):28-30.
[9]刘秀剑.壮膝祛湿汤治疗老年性膝关节骨性关节炎临床疗效观察[J].辽宁中医药大学学报,2018,20(5):95-98.
[10]徐菲,杨克新,刘国恩,等.奇正消痛贴膏治疗骨性关节炎疼痛的药物经济学评价[J].中国全科医学,2017,20(36):4529-4533.
[11]郑洁,袁普卫.骨性关节炎的代谢机制研究进展[J].中国骨质疏松杂志,2018,24(3):406-410.
[12]聂新盼,王文波,王保新,等.骨性关节炎早期诊断方法的评价分析[J].医学综述,2012,18(14):2207-2209.
[13]裴璠,沈姗怡,刘保红.超短波治疗膝骨性关节炎作用机制研究进展[J].中国慢性病预防与控制,2018,26(7):542-545.
[14]刘新荣.超短波加运动疗法治疗膝关节骨性关节炎[J]临床医学,2016,36(7):55-56.
[15]陈文锋,黄海,申文龙.膝骨性关节炎不同中医证型与血清和关节液MMP-3、MMP-7表达的关系[J].浙江中西医结合杂志,2018,28(8):660-663.
[16]丰哲,闫腾龙,韦坚,等.韦贵康分期辨证治疗膝骨性关节炎[J].中华中医药杂志,2014,29(7):2234-2237.
[17]黄明辉,宋进良,陈彦军,等.膝关节骨性关节炎的治疗[J].医学综述,2017,23(16):3250-3260.
[18]邵洁琦,曾志江,杨敏,等.右归丸联合隔姜灸治疗阳虚寒凝型膝骨性关节炎的临床效果[J].中国医药导报,2018,15(10):106-109.
[19]张莹,朱志杰,李萍,等.壮骨伸筋胶囊的抗炎镇痛作用研究[J].中国药房,2016,27(1):35-37.
[20]白斌,李燕琴,李曙明,等.丹参对兔骨性关节炎关节软骨白介素-1β、白介素-6和胰岛素样生长因子-Ⅰ表达的影响[J].中国康复医学杂志,2015,30(10):990-994.
[21]朱让腾,童静玲,罗利飞,等.膝骨性关节炎关节滑液中OPN与VEGF的含量检测及其意义[J].中国卫生检验杂志,2014,24(21):3096-3101.