半导体激光治疗复发性阿弗他溃疡的临床观察
摘要
目的对比半导体激光与复方氯己定含漱液治疗复发性阿弗他溃疡(RAU)的疗效,并探讨同一波长不同功率激光与其疗效的关系。方法 2015年3月至2016年7月选择临床确诊的90例RAU患者,随机分成3组,每组30例。激光治疗组分别采用810nm、300mw和810nm、500mw半导体激光局部照射RAU,对照组采用复方氯己定含漱液治疗RAU,比较3组治疗前后患者的疼痛缓解率、溃疡愈合时间和面积及治疗的有效率。结果激光治疗组和对照组治疗前后比较,激光治疗组的疼痛缓解率高于对照组,溃疡愈合时间和面积均少于对照组,比较差异具有统计学意义(P<0.05);810nm、300mw激光治疗组缓解疼痛效果优于810nm、500mw组和对照组。激光治疗组总有效率优于对照组(P<0.05),810nm、300mw和810nm、500mw组差异无统计学意义(P>0.05)。结论半导体激光治疗RAU的止痛效果显著,能有效促进溃疡愈合。
引文
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[2]Matranga D,Di Fede O,Paderni C,et al.Demographic and behavioural profiles of patients with common oral mucosal lesions by a homogeneity analysis[J].Oral Dis,2012,18(4):396-401.
[3]陈谦明.口腔黏膜病学[M].北京:人民卫生出版社,2014:64-71.
[4]Aggarwal H,Singh MP,Nahar P,et al.Efficacy of lowlevel laser therapy in treatment of recurrent aphthous ulcers-a sham controlled,split mouth follow up study[J].J Clin Dia Res,2014,8(2):218-221.
[5]Yarak S,Okamoto OK.Biostimulation effects of low power laser in the repair process[J].An Bras Dermatol,2010,85(6):849-855.
[6]王国忠,姜行康,孙佳玉,等.阿司匹林对大鼠胃溃疡愈合的影响及其机制[J].中国老年学杂志,2011,31(15):2906-2908.
[7]马缨卫,董莉莉,刘同军,等.660nm激光口腔治疗仪对阿弗他溃疡的疗效评价[J].中国医科大学学报,2015,44(5):443-447.
[8]黎淑芳,李俊,黄敏,等.Er,Cr:YSGG激光治疗轻型复发性阿弗他溃疡短期疗效评价[J].实用口腔医学杂志,2013,29(3):428-430.
[9]李非,李竹,杨牧,等.3A类半导体激光治疗仪的作用机理研究[J].中国医疗器械信息,2013,46(8):46-50.
[10]Misra N,Maiti D,Misra P,et al.940nm diode laser therapy in management of recurrent apthous ulcer[J].BMJ Case Reports,2013(4):1136.
[11]Albrektson M,Hedstr9m L,Bergh H.Recurrent aphthous stomatitis and pain management with low-level laser therapy:a randomized controlled trial[J].Oral Surg Oral Med Oral Pathol Oral Radiol,2014,117(5):590-594.
[12]李凤丽,林松杉,刘世森,等.低功率半导体激光对口腔溃疡局部β-EP的影响[J].军医进修学院学报,2012,33(3):280-281.
[13]李凤丽,林松杉,谷静,等.650nm半导体激光照射对口腔溃疡组织中NO及NOS含量的影响[J].中国激光医学杂志,2012,21(2):90-92.
[14]李晓泓,宋晓琳,徐莉莉,等.不同介入时机针刺三阴交穴对痛经大鼠下丘脑,垂体β-EP含量和HSP70表达的影响研究[J].中华中医药杂志,2010,25(9):1456-14584.
[15]周海娟,顾磊,张玉.氯吡格雷对乙酸诱导大鼠胃溃疡愈合的影响及机制[J].复旦学报(医学版),2013,40(1):50-54.
[16]Lalabonova H,Daskalov H.Clinical assessment of the therapeutic effect of low-level laser therapy on chronic recurrent aphthous stomatitis[J].Biotechnol Biotechnol Equip,2014,28(5):929-933.