镍铬合金义齿在人工唾液中镍离子析出行为的研究
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摘要
目的对镍铬烤瓷冠以及不同铬含量的镍铬金属冠在人工唾液中镍离子的析出行为进行研究。方法将镍铬烤瓷冠以及不同铬含量的镍铬金属冠分别浸泡在pH6.8恒温(37±1)℃的人工唾液环境中,每隔一周将试样取出采用火焰原子吸收光谱法测试镍离子的析出量。结果高铬组金属冠镍离子的析出速率随着时间的推移逐渐增加,于第2周达到高峰,之后逐渐下降;而低铬组在测试周期内(7周),镍离子的析出速率呈持续缓慢上升趋势;与镍铬金属冠相比,镍铬烤瓷冠镍离子的析出量显著降低。结论高铬金属冠具有耐腐蚀性,而镍铬烤瓷冠具有更好的生物安全性。
Objective To study the nickel ion precipitation behavior of Nickel-Chromium(Ni-Cr) alloy ceramic crowns and Ni-Cr alloy metal crowns with different Cr content in artificial saliva. Methods Ni-Cr alloy ceramic crowns and Ni-Cr alloy metal crowns with different Cr content were immersed in the artificial saliva under pH6.8 at a constant temperature(37±1)℃. The samples were taken out every other week, and the concentration of nickel ion was tested by flame atomic absorption spectrometry. Results The nickel ion precipitation rate of Ni-Cr alloy metal crowns with high Cr content increased gradually with time, and reached a peak at the second week,then decreased gradually. While the precipitation rate of nickel ions kept increasing slowly during the test period(7 weeks) in the low Cr content group. Compared with Ni-Cr alloy metal crowns, the amount of nickel ion released from Ni-Cr alloy ceramic crowns decreased significantly. Conclusion The high Cr metal crown has corrosion resistance, while the Ni-Cr ceramic crown has better biological safety.
Objective To study the nickel ion precipitation behavior of Nickel-Chromium(Ni-Cr) alloy ceramic crowns and Ni-Cr alloy metal crowns with different Cr content in artificial saliva. Methods Ni-Cr alloy ceramic crowns and Ni-Cr alloy metal crowns with different Cr content were immersed in the artificial saliva under pH6.8 at a constant temperature(37±1)℃. The samples were taken out every other week, and the concentration of nickel ion was tested by flame atomic absorption spectrometry. Results The nickel ion precipitation rate of Ni-Cr alloy metal crowns with high Cr content increased gradually with time, and reached a peak at the second week,then decreased gradually. While the precipitation rate of nickel ions kept increasing slowly during the test period(7 weeks) in the low Cr content group. Compared with Ni-Cr alloy metal crowns, the amount of nickel ion released from Ni-Cr alloy ceramic crowns decreased significantly. Conclusion The high Cr metal crown has corrosion resistance, while the Ni-Cr ceramic crown has better biological safety.
引文
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[12]Gatin E,Pirvu D,Cara RR.Biocompatibility and sensitization to nickel related corrosion process of Ni-Cr dental metal alloys[J]Dig J Nanomater Bios,2011,6(3):1333-1342.
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[15]Wataha JC,Lockwood PE,Nelson SK.Initial versus subsequent release of elements from dental casting alloys[J].J Oral Rehabil,2010,26(10):798-803.
[16]刘春秀,李瑞平,安峰.血清镍铬元素含量检测用于镍铬合金烤瓷冠修复的研究[J].神经药理学报,2007,24(2):13-15.
[17]杨允久.高金合金与镍铬合金冠桥修复体对牙周组织的远期影响[J].临床医学研究与实践,2016,1(23):69.
[2]孟贺,孙萌,张文茹,等.镍铬合金的细胞毒性及对L929细胞Bax和Bcl-2表达的影响[J].山西医科大学学报,2014,45(10):937-940.
[3]Jones SB,Taylor RL,Collogon JS,et al.Effect of element concentration on nickel release from dental alloys using a novel ion beam method[J].Dent Mater,2010,26(3):249-256.
[4]Borg W,Cassar G,Camilleri L,et al.Surface microstructural changes and release of ions from dental metal alloy removable prostheses in patients suffering from acid reflux[J].JProsthodont,2016,27(2):115-119.
[5]Denizo?lu S,Duymu?ZY.Evaluation of cobalt,chromium,and nickel concentrations in plasma and blood of patients with removable partial dentures[J].Dent MaterJ,2006,25(2):365-370
[6]Ming P,Shao S,Qiu J,et al.Corrosion behavior and cytocompatibility of a Co-Cr and two Ni-Cr dental alloys before and after the pretreatment with a biological saline solution[J]RSC Adv,2017,7(10):5843-5852.
[7]郝钢.齿科用镍铬合金材料的生物安全性能[J].中国组织工程研究,2013,17(8):1461-1464.
[8]金芮竹,赵驰.镍铬合金材料与口腔软组织的生物相容性[J]中国组织工程研究,2012,16(21):3949-3958.
[9]刘春秀,李瑞平,安峰.镍铬合金烤瓷冠修复6个月及1年后血清镍铬元素含量变化:与健康对照者比较(英文)[J].中国组织工程研究,2008,12(23):4583-4586.
[10]胡滨,张富强.镍铬合金在人工唾液中的电化学腐蚀行为[J]中华口腔医学杂志,2003,38(2):140-142.
[11]Lu Y,Chen W,Ke W,et al.Nickel-based(Ni-Cr and Ni-CrBe)alloys used in dental restorations may be a potential cause for immune-mediated hypersensitivity[J].Med Hypotheses,2009,73(5):716-717.
[12]Gatin E,Pirvu D,Cara RR.Biocompatibility and sensitization to nickel related corrosion process of Ni-Cr dental metal alloys[J]Dig J Nanomater Bios,2011,6(3):1333-1342.
[13]岳松龄.口腔内科学[M].第二版.北京:人民卫生出版社,1980.
[14]Collins LM,Dawes C.The surface area of the adult human mouth and thickness of the salivary film covering the teeth and oral mucosa[J].J Dent Res,1987,66(8):1300-1302.
[15]Wataha JC,Lockwood PE,Nelson SK.Initial versus subsequent release of elements from dental casting alloys[J].J Oral Rehabil,2010,26(10):798-803.
[16]刘春秀,李瑞平,安峰.血清镍铬元素含量检测用于镍铬合金烤瓷冠修复的研究[J].神经药理学报,2007,24(2):13-15.
[17]杨允久.高金合金与镍铬合金冠桥修复体对牙周组织的远期影响[J].临床医学研究与实践,2016,1(23):69.