摘要
目的:了解单采血小板献血者体内铁储备状况,为研究和制定更细致和更完善的单采血小板献血者健康检查标准提供有力的实验依据。方法:采用横断面调查,选取2018年10月符合标准的297例单采血小板献血者样本,分析影响铁储备指标的相关性因子,从年度单采血小板次数方面,探讨其对献血者体内血红蛋白(Hb)、血清铁蛋白(SF)及铁缺乏率的影响,全面调查献血者的铁储备状况。结果:单采血小板献血者SF水平与年度单采血小板次数呈负相关(r=-0. 416,P <0. 01);随着年度献血次数的增加,SF水平不断下降,差异具有统计学意义(P <0. 05);随着年度献血次数增加,单采血小板献血者铁缺乏比率有增加的趋势。男性18-23次组铁缺乏比率为12. 5%(8/64),女性18-23次组的铁缺乏比率为40%(6/15)。结论:采供血机构对重复单采血小板献血者可适当减少招募次数,有必要增加SF的检测。
Objective: To understand the iron stores of the plateletpheresis donors,so as to provide some new experimental data for further exploration and more perfect health examination criteria of the plateletpheresis donors.Methods: A total of 297 plateletheresis donors conformed to standard in October 2018 were selected by the cross sectional study. The related factors affecting iron stores were analyzed; the effect of plateletpheresis times of donation on the levels of the hemoglobin(Hb) and serum ferritin(SF) as well as the iron deficency rate in the blood donors was also analyzed;the iron stores in the blood donors was evaluated. Results: The SF level in plateletpheresis donors negatively correlated with annual plateletphersis times of donation(r =-0.416, P <0. 001); The SF level decreased with the increase of annual times of donation(P <0. 05); The iron deficiency rate in plateletpheresis donors showed the increase trend with the increase of annual times of donation. The iron deficiency rate in male and femal with 18-23 times of donation was 12.5%(8/64)and 40%(6/15) respectively. Conclusion: The blood center should reduce recruitment frequency and increase the testing of SF for regularly plateletpheresis donors.
引文
1 Page EA,Coppock JE,Harrison JF.Study of iron stores in regular plateletpheresis donors.Transfus Med,2010;20(1):22-29.
2 Duggan F,O'Sullivan K,Power JP,et al.Serum ferritin in plateletpheresis and whole blood donors.Transfus Apher Sci,2016;55(1):159-163.
3 Li H,Condon F,Kessler D,et al.Evidence of relative iron deficiency in platelet-and plasma-pheresis donors correlates with donation frequency.J Clin Apher,2016;31(6):551-558.
4陈文彬,潘详林.诊断学,第6版.北京:人民卫生出版社,2008:600-622.
5 Boulton F.Managing donors and iron deficiency.Vox Sang,2004;87(Suppl 2):22-24.
6 Cable RG,Glynn SA,Kiss JE,et al.Iron deficiency in blood donors:the REDS-II Donor Iron Status Evaluation(RISE)study.Transfusion,2012;52(4):702-711.
7 Goldman M,Uzicanin S,Osmond L,et al.A large national study of ferritin testing in Canadian blood donors.Transfusion,2017;57(3):564-570.
8 O'Meeara A,Infanti L,Sigle J,et al.Switching iron-deficient whole blood donors to plateletpheresis.Transfusion,2012;52(10):2183-2188.
9 Simon TL,Garry PJ,Hooper EM.Iron stores in blood donors.JA-MA,1981;245(20):2038-2043.
10 Mei Z,Coqswell ME,Parvanta I,et al.Hemoglobin and ferritin are currently the most efficient indicators of population response to iron interventions:an analysis of nine randomized controlled trials.J Nutr,2005;135(8):1974-1980.
11 Kiss JE,Steele WR,Wright DJ,et al.Laboratory variables for assessing iron deficiency in REDS-II Iron Status Evaluation(RISE)blood donors.Transfusion,2013;53(11):2766-2775.