终末期肾病患者腹膜透析和血液透析对自然杀伤细胞和T细胞亚群的影响
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摘要
目的:探讨终末期肾病患者腹膜透析和血液透析对自然杀伤细胞和T细胞亚群的影响。方法:按随机数字表法将100例终末期肾病患者分为对照组和观察组,每组各50例。对照组采取血液透析治疗,观察组采取腹膜透析治疗,分别于治疗前、治疗6个月后测定两组自然杀伤细胞(NK细胞比例、NK细胞活性)和T细胞亚群(包括CD3~+、CD4~+、CD8~+、CD4/CD8)水平变化。结果:治疗后,观察组CD3~+、CD8~+水平高于对照组,CD4~+、CD4/CD8水平低于对照组(P<0.05);治疗后,观察组NK细胞比例、NK细胞活性均低于对照组(P<0.05)。结论:两种透析方式均可改善终末期肾病患者的细胞免疫功能,但腹膜透析较血液透析方式更为显著。
Objective:To investigate the effects of peritoneal dialysis and hemodialysis on natural killer cells and T cell subsets in patients with end-stage renal disease.Methods:100 cases of patients with end-stage renal disease were randomly divided into control group and observation group,with 50 cases in each group.The patients in the control group were treated with hemodialysis,while the patients in the observation group were treated with peritoneal dialysis.The levels of natural killer cells(NK cell ratio,NK cell activity) and T cell subsets(including CD3~+,CD4~+,CD8~+,CD4/CD8) were measured before treatment and 6 months after treatment.Results:After treatment,the levels of CD3~+ and CD8~+ in the observation group were higher than those in the control group,and the levels of CD4~+ and CD4/CD8 were lower than those in the control group(P<0.05).After treatment,the percentage of NK cells and the activity of NK cells in the observation group were lower than those in the control group(P<0.05).Conclusion:Both dialysis methods can improve the cellular immune function of patients with end-stage renal disease,but peritoneal dialysis is more significant than hemodialysis.
Objective:To investigate the effects of peritoneal dialysis and hemodialysis on natural killer cells and T cell subsets in patients with end-stage renal disease.Methods:100 cases of patients with end-stage renal disease were randomly divided into control group and observation group,with 50 cases in each group.The patients in the control group were treated with hemodialysis,while the patients in the observation group were treated with peritoneal dialysis.The levels of natural killer cells(NK cell ratio,NK cell activity) and T cell subsets(including CD3~+,CD4~+,CD8~+,CD4/CD8) were measured before treatment and 6 months after treatment.Results:After treatment,the levels of CD3~+ and CD8~+ in the observation group were higher than those in the control group,and the levels of CD4~+ and CD4/CD8 were lower than those in the control group(P<0.05).After treatment,the percentage of NK cells and the activity of NK cells in the observation group were lower than those in the control group(P<0.05).Conclusion:Both dialysis methods can improve the cellular immune function of patients with end-stage renal disease,but peritoneal dialysis is more significant than hemodialysis.
引文
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[2] 周岩,王涵,周婷婷,等.腹膜透析联合血液透析治疗终末期肾病[J].肾脏病与透析肾移植杂志,2013,22(5):422-426.
[3] 李慧凛,齐尔,蒋更如.终末期糖尿病肾病血液透析和腹膜透析预后的比较研究[J].中国血液净化,2013,12(5):238-242.
[4] 黄洁丽,李江涛,蒋晓峰.血液透析与腹膜透析对终末期肾病患者心肌损伤的影响[J].中华实用诊断与治疗杂志,2015,29(8):817-818.
[5] 肖静,黄忠,卢珊,等.终末期肾病伴晚期肝硬化患者血液透析和腹膜透析临床分析[J].中华肾脏病杂志,2013,29(3):227-228.
[6] 赵琨,齐雪然,隋宾艳,等.终末期肾病腹膜透析预算影响分析[J].中国卫生经济,2015,34(1):66-69.
[7] 金磊.高原地区终末期肾病患者血液透析与腹膜透析对视黄醇结合蛋白影响的观察[J].中国中西医结合肾病杂志,2013,14(3):249-250.
[8] 何川鄂,何小华.两种透析治疗对终末期肾病患者生活质量影响[J].中国药师,2011,14(12):1791-1792.
[9] 孙建洁,陈超,石峰,等.终末期肾病患者腹膜透析和血液透析对NK细胞和T细胞亚群的影响[J].中国临床研究,2015,28(5):548-550.
[10] 汪晶华,刘宇,赵凤龙,等.终末期肾病患者腹膜透析和血液透析对自然杀伤细胞和T细胞亚群的影响[J].中国医药导报,2015,12(18):47-50.
[11] Patel B,Shah M,Dusaj R,et al.Percutaneous coronary intervention and inpatient mortality in patients with advanced chronic kidney disease presenting with acute coronary syndrome[J].Proc (Bayl Univ Med Cent),2017,30(4):400-403.
[12] 李拱榆,唐小玲,曲廖准.不同透析方式及透析龄对终末期肾病患者微炎症状态的影响及临床意义[J].广东医学,2015,36(24):3772-3775.
[13] 唐卫刚,张苗,卢景奎.维持性肾替代治疗患者腹膜透析转血液透析的因素探讨[J].现代医学,2011,39(4):419-423.
[14] Lee SW,Lee A,Yu MY,et al.Is Frailty a Modifiable Risk Factor of Future Adverse Outcomes in Elderly Patients with Incident End-Stage Renal Disease[J].J Korean Med Sci,2017,32(11):1800-1806.
[15] 夏敏,张萍,盛凯翔,等.老年终末期肾病患者血液透析和腹膜透析的预后分析[J].中华肾脏病杂志,2016,32(8):584-591.