去乙酰化转移酶SIRT7的作用及机制研究进展
|
摘要
SIRT7是哺乳动物Sirtuins家族中的一员,定位于核仁,是一种高度特异性的H3K18Ac(组蛋白H3的乙酰化18位赖氨酸残基)去乙酰化酶。近年来的研究发现SIRT7可通过多种途径参与调控核糖体RNA转录、细胞代谢、细胞应激以及DNA损伤修复等生理过程。此外,SIRT7还与衰老、心脏疾病及脂肪肝等密切相关。特别是SIRT7在多种肿瘤如肝癌、胃癌、乳腺癌、膀胱癌、结直肠癌、胰腺癌和头颈鳞状细胞癌等发生发展中起着重要的调节作用。文中综述了SIRT7的细胞及分子生物学作用,并系统总结了其在人类疾病中的研究现状。
As a member of the Sirtuins family in mammals,SIRT7 locates in nucleus and is a highly specific H3K18Ac(acetylated lysine 18 of histone H3) deacetylase.Recent studies showed that SIRT7 could participate in the ribosomal RNA transcription,cell metabolism,cell stress and DNA damage repair through various signaling pathways.In addition,SIRT7 isalso closely related with aging,heart disease and fatty liver.In particular,SIRT7 plays important roles in the regulation of initiation and development of various tumors,such as liver cancer,gastric cancer,breast cancer,bladder cancer,colorectal cancer,and head/neck squamous cell carcinoma.This review describes the cellular and molecular functions of SIRT7,and systematically summarizes recent progress of SIRT7 in human disease.
As a member of the Sirtuins family in mammals,SIRT7 locates in nucleus and is a highly specific H3K18Ac(acetylated lysine 18 of histone H3) deacetylase.Recent studies showed that SIRT7 could participate in the ribosomal RNA transcription,cell metabolism,cell stress and DNA damage repair through various signaling pathways.In addition,SIRT7 isalso closely related with aging,heart disease and fatty liver.In particular,SIRT7 plays important roles in the regulation of initiation and development of various tumors,such as liver cancer,gastric cancer,breast cancer,bladder cancer,colorectal cancer,and head/neck squamous cell carcinoma.This review describes the cellular and molecular functions of SIRT7,and systematically summarizes recent progress of SIRT7 in human disease.
引文
[1]Chalkiadaki A,Guarente L.The multifaceted functions of sirtuins in cancer.Nat Rev Cancer,2015,15(10):608-624.
[2]Kaeberlein M,McVey M,Guarente L.The SIR2/3/4complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.Genes Dev,1999,13(19):2570-2580.
[3]Zhou B,Zhai QW.Sirtuins in glucose and lipid metabolism.Chin Bullet Life Sci,2013,25(2):140-151(in Chinese).周犇,翟琦巍.Sirtuin蛋白家族和糖脂代谢.生命科学,2013,25(2):140-151.
[4]Michishita E,Park JY,Burneskis JM,et al.Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.Mol Biol Cell,2005,16(10):4623-4635.
[5]Kiran S,Chatterjee N,Singh S,et al.Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal.FEBS J,2013,280(14):3451-3466.
[6]Dong Z,Lei Q,Liu LC,et al.Function of SIRT6 in tumor initiation and progression.Chin J Biotech,2016,32(7):870-879(in Chinese).董振,雷倩,刘力超,等.长寿蛋白SIRT6在肿瘤发生发展中的作用.生物工程学报,2016,32(7):870-879.
[7]Dong Z.SIRT6 regulates the warburg effect via CDK4-CCND1 complex[D].Chongqing:Southwest University,2017(in Chinese).董振.SIRT6通过CDK4-CCND1复合体调控沃伯格效应[D].重庆,西南大学,2017.
[8]Blank MF,Grummt I.The seven faces of SIRT7.Transcription,2017,8(2):67-74.
[9]Voelter-Mahlknecht S,Letzel S,Mahlknecht U.Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene.Int J Oncol,2006,28(4):899-908.
[10]Kiran S,Anwar T,Kiran M,et al.Sirtuin 7 in cell proliferation,stress and disease:Rise of the Seventh Sirtuin!Cell Signal,2015,27(3):673-82.
[11]Chen S,Blank MF,Iyer A,et al.SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing.Nat Commun,2016,7:10734.
[12]Li L,Shi L,Yang SD,et al.SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.Nat Commun,2016,7:12235.
[13]Chen SF,Seiler J,Santiago-Reichelt M,et al.Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7.Mol Cell,2013,52(3):303-313.
[14]Ryu D,Jo FS,Lo Sasso G,et al.A SIRT7-dependent acetylation switch of GABP?1 controls mitochondrial function.Cell Metab,2014,20(5):856-869.
[15]Vakhrusheva O,Smolka C,Gajawada P,et al.Sirt7increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice.Circ Res,2008,102(6):703-710.
[16]Lee N,Kim DK,Kim ES,et al.Comparative interactomes of SIRT6 and SIRT7:implication of functional links to aging.Proteomics,2014,14(13/14):1610-1622.
[17]Mo Y,Lin R,Liu P,et al.SIRT7 deacetylates DDB1and suppresses the activity of the CRL4 E3 ligase complexes.FEBS J,2017,284(21):3619-3636.
[18]Hubbi ME,Hu HX,Kshitiz,et al.Sirtuin-7 inhibits the activity of hypoxia-inducible factors.J Biol Chem,2013,288(29):20768-20775.
[19]Tong Z,Wang Y,Zhang XY,et al.SIRT7 is activated by DNA and deacetylates histone H3 in the chromatin context.ACS Chem Biol,2016,11(3):742-747.
[20]Tong Z,Wang M,Wang Y,et al.SIRT7 is an RNA-activated protein lysine deacylase.ACS Chem Biol,2017,12(1):300-310.
[21]Liang P.SAGE genie:a suite with panoramic view of gene expression.Proc Natl Acad Sci USA,2002,99(18):11547-11548.
[22]Tsai YT,Greco TM,Boonmee A,et al.Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.Mol Cell Proteomics,2012,11(5):60-76.
[23]Blank MF,Chen SF,Poetz F,et al.SIRT7-dependent deacetylation of CDK9 activates RNA polymerase IItranscription.Nucleic Acids Res,2017,45(5):2675-2686.
[24]Tsai YC,Greco TM,Cristea IM.Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis.Mol Cell Proteomics,2014,13(1):73-83.
[25]Ford E,Voit R,Liszt G,et al.Mammalian Sir2homolog SIRT7 is an activator of RNA polymerase Itranscription.Genes Dev,2006,20(9):1075-1080.
[26]Santos-Pereira JM,Aguilera A.R loops:new modulators of genome dynamics and function.Nat Rev Genet,2015,16(10):583-597.
[27]Song CL,Hotz-Wagenblatt A,Voit R,et al.SIRT7and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability.Genes Dev,2017,31:1370-1381.
[28]Vazquez BN,Thackray JK,Simonet NG,et al.SIRT7promotes genome integrity and modulates non-homologous end joining DNA repair.EMBO J,2016,35(14):1488-1503.
[29]Kiran S,Oddi V,Ramakrishna G.Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage,SAPK activation and p53 response.Exp Cell Res,2015,331(1):123-141.
[30]Jackson S,Xiong Y.CRL4s:the CUL4-RING E3ubiquitin ligases.Trends Biochem Sci,2009,34(11):562-570.
[31]Karim MF,Yoshizawa T,Sobuz SU,et al.Sirtuin7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.Biochem Biophys Res Commun,2017,490(2):423-428.
[32]Yoshizawa T,Karim MF,Sato Y,et al.SIRT7controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.Cell Metab,2014,19(4):712-721.
[33]Deng JJ,Kong KY,Gao WW,et al.Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription.Biochim Biophys Acta,2017,1860(4):491-501.
[34]Pandey V,Kumar V.Stabilization of SIRT7 deacetylase by viral oncoprotein HBx leads to inhibition of growth restrictive RPS7 gene and facilitates cellular transformation.Sci Rep,2015,5:14806.
[35]Koyuncu E,Budayeva HG,Miteva YV,et al.Sirtuins are evolutionarily conserved viral restriction factors.mBio,2014,5(6):e02249-14.
[36]Shin JY,He M,Liu YF,et al.SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.Cell Rep,2013,5(3):654-665.
[37]Sun LH,Fan GJ,Shan PP,et al.Regulation of energy homeostasis by the ubiquitin-independent REG?proteasome.Nat Commun,2016,7:12497.
[38]López-Otín C,Blasco MA,Partridge L,et al.The hallmarks of aging.Cell,2013,153(6):1194-1217.
[39]Herranz D,Mu?oz-Martin M,Ca?amero M,et al.Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.Nat Commun,2010,1:3.
[40]Li HY,Wang R.Blocking SIRT1 inhibits cell proliferation and promotes aging through the PI3K/AKT pathway.Life Sci,2017,190:84-90.
[41]Wrighton KH.Stem cells:SIRT7,the UPR and HSCageing.Nat Rev Mol Cell Biol,2015,16(5):266-267.
[42]Gu SS,Ran SJ,Liu B,et al.MiR-152 induces human dental pulp stem cell senescence by inhibiting SIRT7expression.FEBS Lett,2016,590(8):1123-1131.
[43]Wyman AE,Noor Z,Fishelevich R,et al.Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts.Am J Physiol Lung Cell Mol Physiol,2017,312(6):L945-L958.
[44]Colombo E,Marine JC,Danovi D,et al.Nucleophosmin regulates the stability and transcriptional activity of p53.Nat Cell Biol,2002,4(7):529-533.
[45]Zhu LX,Ho SC,Sit JWH.The experiences of Chinese patients with coronary heart disease.J Clin Nurs,2012,21(3/4):476-484.
[46]Winnik S,Auwerx J,Sinclair DA,et al.Protective effects of sirtuins in cardiovascular diseases:from bench to bedside.Eur Heart J,2015,36(48):3404-3412.
[47]Liu X.Dysregulation of SIRT7 gene expression in myocardial infarction[D].Jining:Jining Medical University,2017(in Chinese).刘新.SIRT7基因表达调控与急性心肌梗死的分子遗传学研究[D].济宁:济宁医学院,2017.
[48]Ogrodnik M,Miwa S,Tchkonia T,et al.Cellular senescence drives age-dependent hepatic steatosis.Nat Commun,2017,8:15691.
[49]Fang J,Ianni A,Smolka C,et al.Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1.Proc Natl Acad Sci USA,2017,114(40):E8352-E8361.
[50]Kim JK,Noh JH,Jung KH,et al.Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b.Hepatology,2013,57(3):1055-1067.
[51]Hamashima C.Current issues and future perspectives of gastric cancer screening.World J Gastroenterol,2014,20(38):13767-13774.
[52]Zhang S,Chen P,Huang ZA,et al.Sirt7 promotes gastric cancer growth and inhibits apoptosis by epigenetically inhibiting miR-34a.Sci Rep,2015,5:9787.
[53]Fan L,Strasser-Weippl K,Li JJ,et al.Breast cancer in China.Lancet Oncol,2014,15(7):e279-e289.
[54]Aljada A,Saleh AM,Alkathiri M,et al.Altered sirtuin 7 expression is associated with early stage breast cancer.Breast Cancer(Auckl),2015,9:3-8.
[55]Geng Q,Peng HY,Chen FS,et al.High expression of Sirt7 served as a predictor of adverse outcome in breast cancer.Int J Clin Exp Pathol,2015,8(2):1938-1945.
[56]Brown KK,Toker A.The phosphoinositide 3-kinase pathway and therapy resistance in cancer.F1000Prime Rep,2015,7:13.
[57]Yu J,Qin B,Wu FY,et al.Regulation of serine/threonine kinase Akt Activation by NAD+-dependent deacetylase SIRT7.Cell Rep,2017,18(5):1229-1240.
[58]Li D,Li LF.MicroRNA-3666 inhibits breast cancer cell proliferation by targeting sirtuin 7.Mol Med Rep,2017,16(6):8493-8500.
[59]Weigelt B,Peterse JL,van?t Veer LJ.Breast cancer metastasis:markers and models.Nat Rev Cancer,2005,5(8):591-602.
[60]Tang XL,Shi LS,Xie N,et al.SIRT7 antagonizes TGF-?signaling and inhibits breast cancer metastasis.Nat Commun,2017,8:318.
[61]Kim WJ,Bae SC.Molecular biomarkers in urothelial bladder cancer.Cancer Sci,2008,99(4):646-652.
[62]Han YH,Liu YC,Zhang H,et al.Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long non-coding RNA MALAT1.FEBS Lett,2013,587(23):3875-3882.
[63]Siegel R,Desantis C,Jemal A.Colorectal cancer statistics,2014.CA Cancer J Clin,2014,64(2):104-117.
[64]Yu HY,Ye W,Wu JX,et al.Overexpression of sirt7exhibits oncogenic property and serves as a prognostic factor in colorectal cancer.Clin Cancer Res,2014,20(13):3434-3445.
[65]Sauer R,Liersch T,Merkel S,et al.Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer:results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years.J Clin Oncol,2012,30(16):1926-1933.
[66]Tang M,Lu XP,Zhang CH,et al.Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer.Theranostics,2017,7(5):1346-1359.
[67]Lin QJ,Yang F,Jin C,et al.Current status and progress of pancreatic cancer in China.World JGastroenterol,2015,21(26):7988-8003.
[68]Vincent A,Herman J,Schulick R,et al.Pancreatic cancer.Lancet,2011,378(9791):607-620.
[69]McGlynn LM,McCluney S,Jamieson NB,et al.SIRT3&SIRT7:potential novel biomarkers for determining outcome in pancreatic cancer patients.PLoS ONE,2015,10(6):e0131344.
[70]Mehanna H,Paleri V,West CML,et al.Head and neck cancer-Part 1:epidemiology,presentation,and prevention.BMJ,2010,341:c4684.
[71]Lai CC,Lin PM,Lin SF,et al.Altered expression of SIRT gene family in head and neck squamous cell carcinoma.Tumour Biol,2013,34(3):1847-1854.
[72]Lu CT,Hsu CM,Lin PM,et al.The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma.Anticancer Res,2014,34(12):7137-7143.
[73]Malik S,Villanova L,Tanaka SJ,et al.SIRT7inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors.Sci Rep,2015,5:9841.
[74]Singh S,Kumar PU,Thakur S,et al.Expression/localization patterns of sirtuins(SIRT1,SIRT2,and SIRT7)during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.Tumour Biol,2015,36(8):6159-6171.
[75]Liu CJ,Gao Y,Wei L.Altered Sirt7 expression is associated with cervical squamous cell carcinoma.JModern Oncol,2017,25(11):1787-1790(in Chinese).刘春菊,高英,魏力.Sirt7在宫颈鳞状细胞癌组织中的表达及意义.现代肿瘤医学,2017,25(11):1787-1790.
[76]Wang HL,Lu RQ,Xie SH,et al.SIRT7 exhibits oncogenic potential in human ovarian cancer cells.Asian Pac J Cancer Prev,2015,16(8):3573-3577.
[77]Wang W,Zhang XJ,Zheng K,et al.Sirtuin 7 plays an oncogenic role in human osteosarcoma via downregulating CDC4 expression.Am J Cancer Res,2017,7(9):1788-1803.
[2]Kaeberlein M,McVey M,Guarente L.The SIR2/3/4complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.Genes Dev,1999,13(19):2570-2580.
[3]Zhou B,Zhai QW.Sirtuins in glucose and lipid metabolism.Chin Bullet Life Sci,2013,25(2):140-151(in Chinese).周犇,翟琦巍.Sirtuin蛋白家族和糖脂代谢.生命科学,2013,25(2):140-151.
[4]Michishita E,Park JY,Burneskis JM,et al.Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.Mol Biol Cell,2005,16(10):4623-4635.
[5]Kiran S,Chatterjee N,Singh S,et al.Intracellular distribution of human SIRT7 and mapping of the nuclear/nucleolar localization signal.FEBS J,2013,280(14):3451-3466.
[6]Dong Z,Lei Q,Liu LC,et al.Function of SIRT6 in tumor initiation and progression.Chin J Biotech,2016,32(7):870-879(in Chinese).董振,雷倩,刘力超,等.长寿蛋白SIRT6在肿瘤发生发展中的作用.生物工程学报,2016,32(7):870-879.
[7]Dong Z.SIRT6 regulates the warburg effect via CDK4-CCND1 complex[D].Chongqing:Southwest University,2017(in Chinese).董振.SIRT6通过CDK4-CCND1复合体调控沃伯格效应[D].重庆,西南大学,2017.
[8]Blank MF,Grummt I.The seven faces of SIRT7.Transcription,2017,8(2):67-74.
[9]Voelter-Mahlknecht S,Letzel S,Mahlknecht U.Fluorescence in situ hybridization and chromosomal organization of the human Sirtuin 7 gene.Int J Oncol,2006,28(4):899-908.
[10]Kiran S,Anwar T,Kiran M,et al.Sirtuin 7 in cell proliferation,stress and disease:Rise of the Seventh Sirtuin!Cell Signal,2015,27(3):673-82.
[11]Chen S,Blank MF,Iyer A,et al.SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing.Nat Commun,2016,7:10734.
[12]Li L,Shi L,Yang SD,et al.SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability.Nat Commun,2016,7:12235.
[13]Chen SF,Seiler J,Santiago-Reichelt M,et al.Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7.Mol Cell,2013,52(3):303-313.
[14]Ryu D,Jo FS,Lo Sasso G,et al.A SIRT7-dependent acetylation switch of GABP?1 controls mitochondrial function.Cell Metab,2014,20(5):856-869.
[15]Vakhrusheva O,Smolka C,Gajawada P,et al.Sirt7increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice.Circ Res,2008,102(6):703-710.
[16]Lee N,Kim DK,Kim ES,et al.Comparative interactomes of SIRT6 and SIRT7:implication of functional links to aging.Proteomics,2014,14(13/14):1610-1622.
[17]Mo Y,Lin R,Liu P,et al.SIRT7 deacetylates DDB1and suppresses the activity of the CRL4 E3 ligase complexes.FEBS J,2017,284(21):3619-3636.
[18]Hubbi ME,Hu HX,Kshitiz,et al.Sirtuin-7 inhibits the activity of hypoxia-inducible factors.J Biol Chem,2013,288(29):20768-20775.
[19]Tong Z,Wang Y,Zhang XY,et al.SIRT7 is activated by DNA and deacetylates histone H3 in the chromatin context.ACS Chem Biol,2016,11(3):742-747.
[20]Tong Z,Wang M,Wang Y,et al.SIRT7 is an RNA-activated protein lysine deacylase.ACS Chem Biol,2017,12(1):300-310.
[21]Liang P.SAGE genie:a suite with panoramic view of gene expression.Proc Natl Acad Sci USA,2002,99(18):11547-11548.
[22]Tsai YT,Greco TM,Boonmee A,et al.Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.Mol Cell Proteomics,2012,11(5):60-76.
[23]Blank MF,Chen SF,Poetz F,et al.SIRT7-dependent deacetylation of CDK9 activates RNA polymerase IItranscription.Nucleic Acids Res,2017,45(5):2675-2686.
[24]Tsai YC,Greco TM,Cristea IM.Sirtuin 7 plays a role in ribosome biogenesis and protein synthesis.Mol Cell Proteomics,2014,13(1):73-83.
[25]Ford E,Voit R,Liszt G,et al.Mammalian Sir2homolog SIRT7 is an activator of RNA polymerase Itranscription.Genes Dev,2006,20(9):1075-1080.
[26]Santos-Pereira JM,Aguilera A.R loops:new modulators of genome dynamics and function.Nat Rev Genet,2015,16(10):583-597.
[27]Song CL,Hotz-Wagenblatt A,Voit R,et al.SIRT7and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability.Genes Dev,2017,31:1370-1381.
[28]Vazquez BN,Thackray JK,Simonet NG,et al.SIRT7promotes genome integrity and modulates non-homologous end joining DNA repair.EMBO J,2016,35(14):1488-1503.
[29]Kiran S,Oddi V,Ramakrishna G.Sirtuin 7 promotes cellular survival following genomic stress by attenuation of DNA damage,SAPK activation and p53 response.Exp Cell Res,2015,331(1):123-141.
[30]Jackson S,Xiong Y.CRL4s:the CUL4-RING E3ubiquitin ligases.Trends Biochem Sci,2009,34(11):562-570.
[31]Karim MF,Yoshizawa T,Sobuz SU,et al.Sirtuin7-dependent deacetylation of DDB1 regulates the expression of nuclear receptor TR4.Biochem Biophys Res Commun,2017,490(2):423-428.
[32]Yoshizawa T,Karim MF,Sato Y,et al.SIRT7controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.Cell Metab,2014,19(4):712-721.
[33]Deng JJ,Kong KY,Gao WW,et al.Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription.Biochim Biophys Acta,2017,1860(4):491-501.
[34]Pandey V,Kumar V.Stabilization of SIRT7 deacetylase by viral oncoprotein HBx leads to inhibition of growth restrictive RPS7 gene and facilitates cellular transformation.Sci Rep,2015,5:14806.
[35]Koyuncu E,Budayeva HG,Miteva YV,et al.Sirtuins are evolutionarily conserved viral restriction factors.mBio,2014,5(6):e02249-14.
[36]Shin JY,He M,Liu YF,et al.SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease.Cell Rep,2013,5(3):654-665.
[37]Sun LH,Fan GJ,Shan PP,et al.Regulation of energy homeostasis by the ubiquitin-independent REG?proteasome.Nat Commun,2016,7:12497.
[38]López-Otín C,Blasco MA,Partridge L,et al.The hallmarks of aging.Cell,2013,153(6):1194-1217.
[39]Herranz D,Mu?oz-Martin M,Ca?amero M,et al.Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.Nat Commun,2010,1:3.
[40]Li HY,Wang R.Blocking SIRT1 inhibits cell proliferation and promotes aging through the PI3K/AKT pathway.Life Sci,2017,190:84-90.
[41]Wrighton KH.Stem cells:SIRT7,the UPR and HSCageing.Nat Rev Mol Cell Biol,2015,16(5):266-267.
[42]Gu SS,Ran SJ,Liu B,et al.MiR-152 induces human dental pulp stem cell senescence by inhibiting SIRT7expression.FEBS Lett,2016,590(8):1123-1131.
[43]Wyman AE,Noor Z,Fishelevich R,et al.Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts.Am J Physiol Lung Cell Mol Physiol,2017,312(6):L945-L958.
[44]Colombo E,Marine JC,Danovi D,et al.Nucleophosmin regulates the stability and transcriptional activity of p53.Nat Cell Biol,2002,4(7):529-533.
[45]Zhu LX,Ho SC,Sit JWH.The experiences of Chinese patients with coronary heart disease.J Clin Nurs,2012,21(3/4):476-484.
[46]Winnik S,Auwerx J,Sinclair DA,et al.Protective effects of sirtuins in cardiovascular diseases:from bench to bedside.Eur Heart J,2015,36(48):3404-3412.
[47]Liu X.Dysregulation of SIRT7 gene expression in myocardial infarction[D].Jining:Jining Medical University,2017(in Chinese).刘新.SIRT7基因表达调控与急性心肌梗死的分子遗传学研究[D].济宁:济宁医学院,2017.
[48]Ogrodnik M,Miwa S,Tchkonia T,et al.Cellular senescence drives age-dependent hepatic steatosis.Nat Commun,2017,8:15691.
[49]Fang J,Ianni A,Smolka C,et al.Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1.Proc Natl Acad Sci USA,2017,114(40):E8352-E8361.
[50]Kim JK,Noh JH,Jung KH,et al.Sirtuin7 oncogenic potential in human hepatocellular carcinoma and its regulation by the tumor suppressors MiR-125a-5p and MiR-125b.Hepatology,2013,57(3):1055-1067.
[51]Hamashima C.Current issues and future perspectives of gastric cancer screening.World J Gastroenterol,2014,20(38):13767-13774.
[52]Zhang S,Chen P,Huang ZA,et al.Sirt7 promotes gastric cancer growth and inhibits apoptosis by epigenetically inhibiting miR-34a.Sci Rep,2015,5:9787.
[53]Fan L,Strasser-Weippl K,Li JJ,et al.Breast cancer in China.Lancet Oncol,2014,15(7):e279-e289.
[54]Aljada A,Saleh AM,Alkathiri M,et al.Altered sirtuin 7 expression is associated with early stage breast cancer.Breast Cancer(Auckl),2015,9:3-8.
[55]Geng Q,Peng HY,Chen FS,et al.High expression of Sirt7 served as a predictor of adverse outcome in breast cancer.Int J Clin Exp Pathol,2015,8(2):1938-1945.
[56]Brown KK,Toker A.The phosphoinositide 3-kinase pathway and therapy resistance in cancer.F1000Prime Rep,2015,7:13.
[57]Yu J,Qin B,Wu FY,et al.Regulation of serine/threonine kinase Akt Activation by NAD+-dependent deacetylase SIRT7.Cell Rep,2017,18(5):1229-1240.
[58]Li D,Li LF.MicroRNA-3666 inhibits breast cancer cell proliferation by targeting sirtuin 7.Mol Med Rep,2017,16(6):8493-8500.
[59]Weigelt B,Peterse JL,van?t Veer LJ.Breast cancer metastasis:markers and models.Nat Rev Cancer,2005,5(8):591-602.
[60]Tang XL,Shi LS,Xie N,et al.SIRT7 antagonizes TGF-?signaling and inhibits breast cancer metastasis.Nat Commun,2017,8:318.
[61]Kim WJ,Bae SC.Molecular biomarkers in urothelial bladder cancer.Cancer Sci,2008,99(4):646-652.
[62]Han YH,Liu YC,Zhang H,et al.Hsa-miR-125b suppresses bladder cancer development by down-regulating oncogene SIRT7 and oncogenic long non-coding RNA MALAT1.FEBS Lett,2013,587(23):3875-3882.
[63]Siegel R,Desantis C,Jemal A.Colorectal cancer statistics,2014.CA Cancer J Clin,2014,64(2):104-117.
[64]Yu HY,Ye W,Wu JX,et al.Overexpression of sirt7exhibits oncogenic property and serves as a prognostic factor in colorectal cancer.Clin Cancer Res,2014,20(13):3434-3445.
[65]Sauer R,Liersch T,Merkel S,et al.Preoperative versus postoperative chemoradiotherapy for locally advanced rectal cancer:results of the German CAO/ARO/AIO-94 randomized phase III trial after a median follow-up of 11 years.J Clin Oncol,2012,30(16):1926-1933.
[66]Tang M,Lu XP,Zhang CH,et al.Downregulation of SIRT7 by 5-fluorouracil induces radiosensitivity in human colorectal cancer.Theranostics,2017,7(5):1346-1359.
[67]Lin QJ,Yang F,Jin C,et al.Current status and progress of pancreatic cancer in China.World JGastroenterol,2015,21(26):7988-8003.
[68]Vincent A,Herman J,Schulick R,et al.Pancreatic cancer.Lancet,2011,378(9791):607-620.
[69]McGlynn LM,McCluney S,Jamieson NB,et al.SIRT3&SIRT7:potential novel biomarkers for determining outcome in pancreatic cancer patients.PLoS ONE,2015,10(6):e0131344.
[70]Mehanna H,Paleri V,West CML,et al.Head and neck cancer-Part 1:epidemiology,presentation,and prevention.BMJ,2010,341:c4684.
[71]Lai CC,Lin PM,Lin SF,et al.Altered expression of SIRT gene family in head and neck squamous cell carcinoma.Tumour Biol,2013,34(3):1847-1854.
[72]Lu CT,Hsu CM,Lin PM,et al.The potential of SIRT6 and SIRT7 as circulating markers for head and neck squamous cell carcinoma.Anticancer Res,2014,34(12):7137-7143.
[73]Malik S,Villanova L,Tanaka SJ,et al.SIRT7inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors.Sci Rep,2015,5:9841.
[74]Singh S,Kumar PU,Thakur S,et al.Expression/localization patterns of sirtuins(SIRT1,SIRT2,and SIRT7)during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.Tumour Biol,2015,36(8):6159-6171.
[75]Liu CJ,Gao Y,Wei L.Altered Sirt7 expression is associated with cervical squamous cell carcinoma.JModern Oncol,2017,25(11):1787-1790(in Chinese).刘春菊,高英,魏力.Sirt7在宫颈鳞状细胞癌组织中的表达及意义.现代肿瘤医学,2017,25(11):1787-1790.
[76]Wang HL,Lu RQ,Xie SH,et al.SIRT7 exhibits oncogenic potential in human ovarian cancer cells.Asian Pac J Cancer Prev,2015,16(8):3573-3577.
[77]Wang W,Zhang XJ,Zheng K,et al.Sirtuin 7 plays an oncogenic role in human osteosarcoma via downregulating CDC4 expression.Am J Cancer Res,2017,7(9):1788-1803.