摘要
目的探讨中性粒细胞与淋巴细胞比值(NLR)和预后营养指数(PNI)在膀胱癌根治术患者预后中的相关性。方法回顾性分析膀胱癌根治术患者213例,根据术前NLR和PNI,将其分为低NLR组(NLR<2.89)和高NLR组(NLR≥2.89),低PNI组(PNI<46.08)和高PNI组(PNI≥46.08)。分析预后相关因素:NLR、PNI、年龄、性别、组织学分级、病理T分期、肿瘤大小、肿瘤数目等。结果多因素分析结果显示:NLR(P=0.023)、PNI(P=0.038)、肾积水(P=0.014)、组织学分级(P=0.043)、病理T分期(P<0.001)是影响患者无进展生存期(PFS)的独立危险因素。NLR(P=0.008)、PNI(P=0.012)、年龄(P=0.029)、肾积水(P=0.002)、组织学分级(P=0.009)、病理T分期(P<0.001)是影响患者总生存期(OS)的独立危险因素;NLR≥2.89及PNI<46.08预示膀胱癌根治术患者的PFS和OS较短。结论 NLR和PNI是膀胱癌根治术患者预后的独立危险因素,高NLR和低PNI与患者预后不良相关。
Objective To explore the correlation between neutrophil-lymphocyte ratio(NLR) and prognostic nutritional index(PNI) in the prognosis of patients with bladder cancer undergoing radical cystectomy.Methods A retrospective study of 213 patients with bladder cancer who underwent radical cystectomy. According to the values of preoperative NLR and PNI,patients were divided into low NLR group(NLR<2.89) and high NLR group(NLR≥2.89), low PNI group(PNI<46.08) and high PNI group(PNI≥46.08). The potential prognostic factors were analyzed such as NLR, PNI, age, gender, histological grade, pathological T stage, tumor size, number of tumors, etc.Results Multivariate analysis showed that NLR(P=0.023), PNI(P=0.038), hydronephrosis(P=0.014)histological grade( P = 0. 043),and pathological T stage( P < 0. 001) were independent risk factors for progressionfree survival( PFS) of patients underwent radical cystectomy; NLR( P = 0. 008),PNI( P = 0. 012),age( P =0. 029),hydronephrosis( P = 0. 002),histological grade( P = 0. 009),pathological T stage( P < 0. 001) were independent risk factors for overall survival( OS) of patients underwent radical cystectomy. Patients with NLR≥2. 89 and/or PNI < 46. 08 predicted shorter progression-free survival and overall survival. Conclusion NLR and PNI are independent risk factors for the prognosis of patients underwent radical cystectomy. Higher NLR and lower PNI are associated with patients a poor prognosis.
引文
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