广东汉族人ABO血型与卵巢癌的相关性研究
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摘要
目的:探讨广东省汉族人ABO血型与卵巢癌的相关性。方法:回顾分析2010年1月至2018年8月于广东省第二人民医院行手术治疗的广东籍汉族卵巢癌患者的ABO血型及手术病理资料,探讨ABO血型与卵巢癌发生的关系。结果:不同血型患者的年龄、病理分型及手术病理分期等比较,差异均无统计学意义(P>0.05);卵巢癌患者的ABO血型表型构成比的差异有统计学意义(P<0.05),广东汉族人群中B型血者为卵巢癌的低风险人群,非B型血可能增加罹患卵巢癌的风险(OR=0.56,95%CI=0.37～0.84,P=0.005)。结论:卵巢癌的发生与ABO血型存在一定的关系,非B型血者较B型血者罹患卵巢癌的风险更高。
Objective: To explore the relationship between ABO blood groups and ovarian cancer in Hans of Guangdong Province. Methods: We retrospectively analyzed the ABO blood groups and surgical pathology data of patients with ovarian cancer who underwent surgery in the Guangdong Sencond Provincial General Hospital from Jan.2010 to Aug.2018.To explore the relationship between ABO blood type and ovarian cancer.Results: There were no statistically significant differences in age,pathological type and surgical pathological stage between the different blood type patients( P>0.05).There was a significant difference in the constituent ratio of ABO blood group between ovarian cancer patients( P<0.05).The patients with B blood group had a low risk of ovarian cancer,non-B blood groups might increase the risk of ovarian cancer( OR = 0.56,95%CI = 0.37 ～ 0.84,P = 0.005).Conclusion: The occurrence of ovarian cancer may have a certain relationship with the ABO blood type. Those with non-B blood type have a higher risk of developing ovarian cancer than those with B blood type.
Objective: To explore the relationship between ABO blood groups and ovarian cancer in Hans of Guangdong Province. Methods: We retrospectively analyzed the ABO blood groups and surgical pathology data of patients with ovarian cancer who underwent surgery in the Guangdong Sencond Provincial General Hospital from Jan.2010 to Aug.2018.To explore the relationship between ABO blood type and ovarian cancer.Results: There were no statistically significant differences in age,pathological type and surgical pathological stage between the different blood type patients( P>0.05).There was a significant difference in the constituent ratio of ABO blood group between ovarian cancer patients( P<0.05).The patients with B blood group had a low risk of ovarian cancer,non-B blood groups might increase the risk of ovarian cancer( OR = 0.56,95%CI = 0.37 ～ 0.84,P = 0.005).Conclusion: The occurrence of ovarian cancer may have a certain relationship with the ABO blood type. Those with non-B blood type have a higher risk of developing ovarian cancer than those with B blood type.
引文
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[21]崔海涛,张丽敏,赵琳,等.ABO血型与卵巢肿瘤发生危险度及卵巢恶性肿瘤化疗敏感性关系[J].中华实用诊断与治疗杂志,2016,30(8):783-785
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[23]Zhang W,Xu Q,Zhuang Y,et al.Novel association of soluble intercellular adhesion molecule 1 and soluble P-selectin with the ABO blood group in a Chinese population[J].Exp Ther Med,2016,12(2):909-914
[24]Kuchenbaecker KB,Ramus SJ,Tyrer J,et al.Identification of six new susceptibility loci for invasive epithelial ovarian cancer[J].Nature Genet,2015,47(2):164-171
[25]Bildik G,Acilan C,Sahin GN,et al.C-Abl is not activated in DNA damage-induced and Tap63-mediated oocyte apoptosis in human ovary[J].Cell Death Dis,2018,9(10):943
[26]Marinaccio M,Traversa A,Carioggia E,et al.Blood groups of the ABO system and survival rate in gynecologic tumors[J].Minerva Ginecol,1995,47(3):69-76
[2]Torre LA,Trabert B,De Santis CE,et al.Ovarian cancer statistics[J].CA,2018,68(4):284-296
[3]李慧,王丹,张学慧.ABO血型与卵巢癌患者预后的关系[J].天津医药,2018,46(1):77-80
[4]卢淮武,林仲秋.《2018 NCCN卵巢癌包括输卵管癌及原发性腹膜癌临床实践指南》解读[J].中国实用妇科与产科杂志,2018,34(5):526-536
[5]Ledermann JA.First-line treatment of ovarian cancer:questions and controversies to address[J].Ther Adv Med Oncol,2018,10(15):386138327
[6]曾龙佳,卢芳芳,易素祎,等.晚期卵巢癌的新辅助化疗应用[J].中国妇幼保健,2016,31(14):2975-2978
[7]Gu Z,He Y,Zhang Y,et al.Postprandial increase in serum CA125 as a surrogate biomarker for early diagnosis of ovarian cancer[J].J Transl Med,2018,16(1):114
[8]Zouine S,Marnissi F,Otmani N,et al.ABO blood groups in relation to breast carcinoma incidence and associated prognostic factors in Moroccan women[J].Med Oncol,2016,33(7):67
[9]Wang W,Liu L,Wang Z,et al.ABO blood group and esophageal carcinoma risk:from a case-control study in Chinese population to meta-analysis[J].Cancer Causes Control,2014,25(10):1369-1377
[10]Xu Y,Jiang T,Cui Y,et al.Prognostic value of ABOblood group in patients with gastric cancer[J].J Surg Res,2016,201(1):188-195
[11]Sun W,Wen C,Lin J,et al.ABO blood types and cancer risk-A cohort study of 339,432 subjects in Taiwan[J].Cancer Epidemiol,2015,39(2):150-156
[12]Mattos LCD.Structural diversity and biological importance of ABO,H,Lewis and secretor histo-blood group carbohydrates[J].Rev Bras Hematol Hemoter,2016,38(4):331-340
[13]Gates MA,Wolpin BM,Cramer DW,et al.ABO blood group and incidence of epithelial ovarian cancer[J].Int J Cancer,2011,128(2):482-486
[14]Rummel SK,Ellsworth RE.The role of the histoblood ABO group in cancer[J].Future Sci OA,2016,2(2):FSO107
[15]Huang JY,Wang R,Gao Y,et al.ABO blood type and the risk of cancer-findings from the Shanghai Cohort Study[J].Plos One,2017,12(9):e184295
[16]Yuzhalin AE,Kutikhin AG.ABO and Rh Blood Groups in relation to ovarian,endometrial and cervical cancer risk among the population of south-east siberia[J].Asian Pacific J Cancer Prev,2012,13(10):5091-5096
[17]Montavon SC,Schoetzau A,Kettelhack H,et al.ABOblood groups as a prognostic factor for recurrence in ovarian and vulvar cancer[J].PLoS One,2018,13(3):e195213
[18]Cozzi GD,Levinson RT,Toole H,et al.Blood type,ABOgenetic variants,and ovarian cancer survival[J].Plos One,2017,12(4):e175119
[19]Poole EM,Gates MA,High BA,et al.ABO blood group and risk of epithelial ovarian cancer within the ovarian cancer association consortium[J].Cancer Causes Control,2012,23(11):1805-1810
[20]周冬燕,刘敏,李喜莹,等.卵巢肿瘤患者ABO和Rh(D)血型分布情况分析[J].北京医学,2014,36(6):481-483
[21]崔海涛,张丽敏,赵琳,等.ABO血型与卵巢肿瘤发生危险度及卵巢恶性肿瘤化疗敏感性关系[J].中华实用诊断与治疗杂志,2016,30(8):783-785
[22]Zhou J,Yang L,He Z,et al.Prognostic impact of ABOblood group on the survival in patients with ovarian cancer[J].J Cancer,2015,6(10):970-975
[23]Zhang W,Xu Q,Zhuang Y,et al.Novel association of soluble intercellular adhesion molecule 1 and soluble P-selectin with the ABO blood group in a Chinese population[J].Exp Ther Med,2016,12(2):909-914
[24]Kuchenbaecker KB,Ramus SJ,Tyrer J,et al.Identification of six new susceptibility loci for invasive epithelial ovarian cancer[J].Nature Genet,2015,47(2):164-171
[25]Bildik G,Acilan C,Sahin GN,et al.C-Abl is not activated in DNA damage-induced and Tap63-mediated oocyte apoptosis in human ovary[J].Cell Death Dis,2018,9(10):943
[26]Marinaccio M,Traversa A,Carioggia E,et al.Blood groups of the ABO system and survival rate in gynecologic tumors[J].Minerva Ginecol,1995,47(3):69-76