基质金属蛋白酶ADAMTS的研究进展
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摘要
ADAMTS是含有TSP基序的分泌性多结构域蛋白水解酶。ADAMTS基因的突变或过表达与多种生理学和病理学过程相关。ADAMTS基因的过表达促进了细胞外基质成分的降解,加速了关节炎和动脉粥样硬化的疾病进程。ADAMTS基因的突变则与肿瘤的生长和侵袭以及遗传性发育紊乱等密切相关。该文将结合作者的研究工作,重点对ADAMTS-7的当前研究概况进行综述,讨论其结构、功能、调节及其在相关炎性疾病中的作用等。
The ADAMTS proteinases are a group of multi-domain and secreted metalloproteinase containing the thrombospondin motifs. Mutations in the ADAMTS gene or overexpression of ADAMTS gene is associated with a variety of physiological and pathological processes. Overexpression of ADAMTS gene promotes the breakdown of extracellular matrix and accelerates the development of arthritis and atherosclerosis. Mutations in the ADAMTS gene are closely related to cancer cells growth and metastasis and human genetic disorders. This review based on our results and provided an overview of current knowledge of ADAMTS-7, including its structure, function, gene regulation and inflammatory disease involvement.
The ADAMTS proteinases are a group of multi-domain and secreted metalloproteinase containing the thrombospondin motifs. Mutations in the ADAMTS gene or overexpression of ADAMTS gene is associated with a variety of physiological and pathological processes. Overexpression of ADAMTS gene promotes the breakdown of extracellular matrix and accelerates the development of arthritis and atherosclerosis. Mutations in the ADAMTS gene are closely related to cancer cells growth and metastasis and human genetic disorders. This review based on our results and provided an overview of current knowledge of ADAMTS-7, including its structure, function, gene regulation and inflammatory disease involvement.
引文
1 Wagstaff L,Kelwick R,Decock J,Edwards DR.The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis.Front Biosci(Landmark Ed)2011;16:1861-72.
2 Kuno K,Kanada N,Nakashima E,Fujiki F,Ichimura F,Matsushima K.Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene.J Biol Chem1997;272(1):556-62.
3 Nicholson AC,Malik SB,Logsdon JM Jr,van Meir EG.Functional evolution of ADAMTS genes:Evidence from analyses of phylogeny and gene organization.BMC Evol Biol 2005;5:11.
4 Cal S,Arguelles JM,Fernandez PL,Lopez-Otin C.Identification,characterization,and intracellular processing of ADAM-TS12,a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats.J Biol Chem 2001;276(21):17932-40.
5 Rodriguez-Manzaneque JC,Milchanowski AB,Dufour EK,Leduc R,Iruela-Arispe ML.Characterization of METH-1/ADAMTS1 processing reveals two distinct active forms.J Biol Chem 2000;275(43):33471-9.
6 Gerhardt S,Hassall G,Hawtin P,McCall E,Flavell L,Minshull C,et al.Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains.J Mol Biol 2007;373(4):891-902.
7 Mosyak L,Georgiadis K,Shane T,Svenson K,Hebert T,McDonagh T,et al.Crystal structures of the two major aggrecan degrading enzymes,ADAMTS4 and ADAMTS5.Protein Sci 2008;17(1):16-21.
8 Llamazares M,Cal S,Quesada V,Lopez-Otin C.Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain.J Biol Chem 2003;278(15):13382-9.
9 Tortorella MD,Burn TC,Pratta MA,Abbaszade I,Hollis JM,Liu R,et al.Purification and cloning of aggrecanase-1:A member of the ADAMTS family of proteins.Science 1999;284(5420):1664-6.
10 Glasson SS,Askew R,Sheppard B,Carito B,Blanchet T,Ma HL,et al.Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.Nature 2005;434(7033):644-8.
11 Colige A,Li SW,Sieron AL,Nusgens BV,Prockop DJ,Lapiere CM.cDNA cloning and expression of bovine procollagen I Nproteinase:A new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components.Proc Natl Acad Sci USA 1997;94(6):2374-9.
12 Wang WM,Lee S,Steiglitz BM,Scott IC,Lebares CC,Allen ML,et al.Transforming growth factor-beta induces secretion of activated ADAMTS-2.A procollagen III N-proteinase.J Biol Chem 2003;278(21):19549-57.
13 Fernandes RJ,Hirohata S,Engle JM,Colige A,Cohn DH,Eyre DR,et al.Procollagen II amino propeptide processing by ADAMTS-3.Insights on dermatosparaxis.J Biol Chem 2001;276(34):31502-9.
14 Colige A,Vandenberghe I,Thiry M,Lambert CA,van Beeumen J,Li SW,et al.Cloning and characterization of ADAMTS-14,a novel ADAMTS displaying high homology with ADAMTS-2and ADAMTS-3.J Biol Chem 2002;277(8):5756-66.
15 Soejima K,Matsumoto M,Kokame K,Yagi H,Ishizashi H,Maeda H,et al.ADAMTS-13 cysteine-rich/spacer domains are functionally essential for von Willebrand factor cleavage.Blood2003;102(9):3232-7.
16 Porter S,Clark IM,Kevorkian L,Edwards DR.The ADAMTS metalloproteinases.Biochem J 2005;386(Pt 1):15-27.
17 Shindo T,Kurihara H,Kuno K,Yokoyama H,Wada T,Kurihara Y,et al.ADAMTS-1:A metalloproteinase-disintegrin essential for normal growth,fertility,and organ morphology and function.J Clin Invest 2000;105(10):1345-52.
18 Freitas VM,do Amaral JB,Silva TA,Santos ES,Mangone FR,Pinheiro Jde J,et al.Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion.Mol Cancer 2013;12:2.
19 Colige A,Sieron AL,Li SW,Schwarze U,Petty E,Wertelecki W,et al.Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I Nproteinase gene.Am J Hum Genet 1999;65(2):308-17.
20 Dubail J,Kesteloot F,Deroanne C,Motte P,Lambert V,Rakic JM,et al.ADAMTS-2 functions as anti-angiogenic and antitumoral molecule independently of its catalytic activity.Cell Mol Life Sci 2010;67(24):4213-32.
21 Verma P,Dalal K.ADAMTS-4 and ADAMTS-5:Key enzymes in osteoarthritis.J Cell Biochem 2011;112(12):3507-14.
22 Wagsater D,Bjork H,Zhu C,Bjorkegren J,Valen G,Hamsten A,et al.ADAMTS-4 and-8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.Atherosclerosis 2008;196(2):514-22.
23 Nakada M,Miyamori H,Kita D,Takahashi T,Yamashita J,Sato H,et al.Human glioblastomas overexpress ADAMTS-5 that degrades brevican.Acta Neuropatho 2005;110(3):239-46.
24 Didangelos A,Mayr U,Monaco C,Mayr M.Novel role of ADAMTS-5 protein in proteoglycan turnover and lipoprotein retention in atherosclerosis.J Biol Chem 2012;287(23):19341-5.
25 Wang L,Zheng J,Bai X,Liu B,Liu CJ,Xu Q,et al.ADAMTS-7mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries.Circ Res 2009;104(5):688-98.
26 Dunn JR,Reed JE,du Plessis DG,Shaw EJ,Reeves P,Gee AL,et al.Expression of ADAMTS-8,a secreted protease with antiangiogenic properties,is downregulated in brain tumours.Br J Cancer 2006;94(8):1186-93.
27 Ocak Z,Acar M,Gunduz E,Gunduz M,Demircan K,Uyeturk U,et al.Effect of hypericin on the ADAMTS-9 and ADAMTS-8gene expression in MCF7 breast cancer cells.Eur Rev Med Pharmacol Sci 2013;17(9):1185-90.
28 Sengle G,Tsutsui K,Keene DR,Tufa SF,Carlson EJ,Charbonneau NL,et al.Microenvironmental regulation by fibrillin-1.PLoS Genet 2012;8(1):e1002425.
29 Moncada-Pazos A,Obaya AJ,Llamazares M,Heljasvaara R,Suarez MF,Colado E,et al.ADAMTS-12 metalloprotease is necessary for normal inflammatory response.J Biol Chem 2012;287(47):39554-63.
30 Moncada-Pazos A,Obaya AJ,Fraga MF,Viloria CG,Capella G,Gausachs M,et al.The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.J Cell Sci 2009;122 (Pt 16):2906-13.
31 El Hour M,Moncada-Pazos A,Blacher S,Masset A,Cal S,Berndt S,et al.Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis.Oncogene 2010;29(20):3025-32.
32 Johnston P,Chojnowski AJ,Davidson RK,Riley GP,Donell ST,Clark IM.A complete expression profile of matrix-degrading metalloproteinases in Dupuytren’s disease.J Hand Surg Am2007;32(3):343-51.
33 Molokwu CN,Adeniji OO,Chandrasekharan S,Hamdy FC,Buttle DJ.Androgen regulates ADAMTS15 gene expression in prostate cancer cells.Cancer Invest 2010;28(7):698-710.
34 Gao S,De Geyter C,Kossowska K,Zhang H.FSH stimulates the expression of the ADAMTS-16 protease in mature human ovarian follicles.Mol Hum Reprod 2007;13(7):465-71.
35 Morales J,Al-Sharif L,Khalil DS,Shinwari JM,Bavi P,AlMahrouqi RA,et al.Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia,ectopia lentis,glaucoma,spherophakia,and short stature.Am J Hum Genet 2009;85(5):558-68.
36 Aldahmesh MA,Khan AO,Mohamed JY,Alkuraya H,Ahmed H,Bobis S,et al.Identification of ADAMTS18 as a gene mutated in Knobloch syndrome.J Med Genet 2011;48(9):597-601.
37 Peluso I,Conte I,Testa F,Dharmalingam G,Pizzo M,Collin RW,et al.The ADAMTS18 gene is responsible for autosomal recessive early onset severe retinal dystrophy.Orphanet J Rare Dis2013;8:16.
38 Knauff EA,Franke L,van Es MA,van den Berg LH,van der Schouw YT,Laven JS,et al.Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene.Hum Reprod 2009;24(9):2372-8.
39 Liu CJ.The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.Nat Clin Pract Rheumatol 2009;5(1):38-45.
40 Stanton H,Melrose J,Little CB,Fosang AJ.Proteoglycan degradation by the ADAMTS family of proteinases.Biochim Biophys Acta 2011;1812(12):1616-29.
41 Briggs MD,Hoffman SM,King LM,Olsen AS,Mohrenweiser H,Leroy JG,et al.Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene.Nat Genet1995;10(3):330-6.
42 Briggs MD,Mortier GR,Cole WG,King LM,Golik SS,Bonaventure J,et al.Diverse mutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum.Am J Hum Genet 1998;62(2):311-9.
43 Cohn DH,Briggs MD,King LM,Rimoin DL,Wilcox WR,Lachman RS,et al.Mutations in the cartilage oligomeric matrix protein(COMP)gene in pseudoachondroplasia and multiple epiphyseal dysplasia.Ann N Y Acad Sci 1996;785:188-94.
44 Liu CJ,Kong W,Ilalov K,Yu S,Xu K,Prazak L,et al.ADAMTS-7:A metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein.FASEB J 2006;20(7):988-90.
45 Liu CJ,Kong W,Xu K,Luan Y,Ilalov K,Sehgal B,et al.ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein.J Biol Chem 2006;281(23):15800-8.
46 Luan Y,Kong L,Howell DR,Ilalov K,Fajardo M,Bai XH,et al.Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin.Osteoarthritis Cartilage 2008;16(11):1413-20.
47 Bai XH,Wang DW,Kong L,Zhang Y,Luan Y,Kobayashi T,et al.ADAMTS-7,a direct target of PTHrP,adversely regulates endochondral bone growth by associating with and inactivating GEP growth factor.Mol Cell Biol 2009;29(15):4201-19.
48 Lai Y,Bai X,Zhao Y,Tian Q,Liu B,Lin EA,et al.ADAMTS-7forms a positive feedback loop with TNF-alpha in the pathogenesis of osteoarthritis.Ann Rheum Dis 2013;73(8):1575-84.
49 Buckland J.Osteoarthritis:Positive feedback between ADAMTS-7 and TNF in OA.Nat Rev Rheumatol 2013;9(10):566.
50 Worley JR,Baugh MD,Hughes DA,Edwards DR,Hogan A,Sampson MJ,et al.Metalloproteinase expression in PMA-stimulated THP-1 cells.Effects of peroxisome proliferator-activated receptor-gamma(PPAR gamma)agonists and 9-cis-retinoic acid.J Biol Chem 2003;278(51):51340-6.
51 Jonsson-Rylander AC,Nilsson T,Fritsche-Danielson R,Hammarstrom A,Behrendt M,Andersson JO,et al.Role of ADAMTS-1 in atherosclerosis:Remodeling of carotid artery,immunohistochemistry,and proteolysis of versican.Arterioscler Thromb Vasc Biol 2005;25(1):180-5.
52 van Setten J,Isgum I,Smolonska J,Ripke S,de Jong PA,Oudkerk M,et al.Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction.Atherosclerosis 2013;228(2):400-5.
53 Reilly MP,Li M,He J,Ferguson JF,Stylianou IM,Mehta NN,et al.Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis:Two genomewide association studies.Lancet 2011;377(9763):383-92.
54 Pu X,Xiao Q,Kiechl S,Chan K,Ng FL,Gor S,et al.ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant.Am J Hum Genet 2013;92(3):366-74.
55 Stary HC,Chandler AB,Dinsmore RE,Fuster V,Glagov S,Insull W Jr,et al.A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis.A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis,American Heart Association.Circulation 1995;92(5):1355-74.
56 Patel RS,Ye S.ADAMTS7:A promising new therapeutic target in coronary heart disease.Expert Opin Ther Targets 2013;17(8):863-867.
57 Wang L,Wang X,Kong W.ADAMTS-7,a novel proteolytic culprit in vascular remodeling.Sheng Li Xue Bao 2010;62(4):285-94.
58 Wang L,Zheng J,Du Y,Huang Y,Li J,Liu B,et al.Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1)integrin.Circ Res 2010;106(3):514-25.
59 Du Y,Gao C,Liu Z,Wang L,Liu B,He F,et al.Upregulation of a disintegrin and metalloproteinase with thrombospondin motifs-7by miR-29 repression mediates vascular smooth muscle calcification.Arterioscler Thromb Vasc Biol 2012;32(11):2580-8.
60 Hanby HA,Zheng XL.Biochemistry and physiological functions of ADAMTS7 metalloprotease.Adv Biochem 2013;1(3):doi:10 .11648/j.ab.20130103.11.
61 Jones GC,Riley GP.ADAMTS proteinases:A multi-domain,multi-functional family with roles in extracellular matrix turnover and arthritis.Arthritis Res Ther 2005;7(4):160-9.
62 Bevitt DJ,Mohamed J,Catterall JB,Li Z,Arris CE,Hiscott P,et al.Expression of ADAMTS metalloproteinases in the retinal pigment epithelium derived cell line ARPE-19:Transcriptional regulation by TNFalpha.Biochim Biophys Acta 2003;1626(1/2/3):83-91.
63 Sylvester J,Liacini A,Li WQ,Zafarullah M.Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3,-13 and aggrecanase-1 genes in articular chondrocytes.Cell Signal 2004;16(4):469-76.
64 Yamanishi Y,Boyle DL,Clark M,Maki RA,Tortorella MD,Arner EC,et al.Expression and regulation of aggrecanase in arthritis:the role of TGF-beta.J Immunol 2002;168(3):1405-12.
65 Bevitt DJ,Li Z,Lindrop JL,Barker MD,Clarke MP,McKie N.Analysis of full length ADAMTS6 transcript reveals alternative splicing and a role for the 5’untranslated region in translational control.Gene 2005;359:99-110.
66 Hurskainen TL,Hirohata S,Seldin MF,Apte SS.ADAM-TS5,ADAM-TS6,and ADAM-TS7,novel members of a new family of zinc metalloproteases.General features and genomic distribution of the ADAM-TS family.J Biol Chem 1999;274(36):25555-63.
67 Apte SS.A disintegrin-like and metalloprotease(reprolysin type)with thrombospondin type 1 motifs:the ADAMTS family.Int J Biochem Cell Biol 2004;36(6):981-5.
68 Nusgens BV,Verellen-Dumoulin C,Hermanns-Le T,de Paepe A,Nuytinck L,Pierard GE,et al.Evidence for a relationship between Ehlers-Danlos type VII C in humans and bovine dermatosparaxis.Nat Genet 1992;1(3):214-7.
69 Aldahmesh MA,Alshammari MJ,Khan AO,Mohamed JY,Alhabib FA,Alkuraya FS.The syndrome of microcornea,myopic chorioretinal atrophy,and telecanthus(MMCAT)is caused by mutations in ADAMTS18.Hum Mutat 2013;34(9):1195-9.
2 Kuno K,Kanada N,Nakashima E,Fujiki F,Ichimura F,Matsushima K.Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene.J Biol Chem1997;272(1):556-62.
3 Nicholson AC,Malik SB,Logsdon JM Jr,van Meir EG.Functional evolution of ADAMTS genes:Evidence from analyses of phylogeny and gene organization.BMC Evol Biol 2005;5:11.
4 Cal S,Arguelles JM,Fernandez PL,Lopez-Otin C.Identification,characterization,and intracellular processing of ADAM-TS12,a novel human disintegrin with a complex structural organization involving multiple thrombospondin-1 repeats.J Biol Chem 2001;276(21):17932-40.
5 Rodriguez-Manzaneque JC,Milchanowski AB,Dufour EK,Leduc R,Iruela-Arispe ML.Characterization of METH-1/ADAMTS1 processing reveals two distinct active forms.J Biol Chem 2000;275(43):33471-9.
6 Gerhardt S,Hassall G,Hawtin P,McCall E,Flavell L,Minshull C,et al.Crystal structures of human ADAMTS-1 reveal a conserved catalytic domain and a disintegrin-like domain with a fold homologous to cysteine-rich domains.J Mol Biol 2007;373(4):891-902.
7 Mosyak L,Georgiadis K,Shane T,Svenson K,Hebert T,McDonagh T,et al.Crystal structures of the two major aggrecan degrading enzymes,ADAMTS4 and ADAMTS5.Protein Sci 2008;17(1):16-21.
8 Llamazares M,Cal S,Quesada V,Lopez-Otin C.Identification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain.J Biol Chem 2003;278(15):13382-9.
9 Tortorella MD,Burn TC,Pratta MA,Abbaszade I,Hollis JM,Liu R,et al.Purification and cloning of aggrecanase-1:A member of the ADAMTS family of proteins.Science 1999;284(5420):1664-6.
10 Glasson SS,Askew R,Sheppard B,Carito B,Blanchet T,Ma HL,et al.Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.Nature 2005;434(7033):644-8.
11 Colige A,Li SW,Sieron AL,Nusgens BV,Prockop DJ,Lapiere CM.cDNA cloning and expression of bovine procollagen I Nproteinase:A new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components.Proc Natl Acad Sci USA 1997;94(6):2374-9.
12 Wang WM,Lee S,Steiglitz BM,Scott IC,Lebares CC,Allen ML,et al.Transforming growth factor-beta induces secretion of activated ADAMTS-2.A procollagen III N-proteinase.J Biol Chem 2003;278(21):19549-57.
13 Fernandes RJ,Hirohata S,Engle JM,Colige A,Cohn DH,Eyre DR,et al.Procollagen II amino propeptide processing by ADAMTS-3.Insights on dermatosparaxis.J Biol Chem 2001;276(34):31502-9.
14 Colige A,Vandenberghe I,Thiry M,Lambert CA,van Beeumen J,Li SW,et al.Cloning and characterization of ADAMTS-14,a novel ADAMTS displaying high homology with ADAMTS-2and ADAMTS-3.J Biol Chem 2002;277(8):5756-66.
15 Soejima K,Matsumoto M,Kokame K,Yagi H,Ishizashi H,Maeda H,et al.ADAMTS-13 cysteine-rich/spacer domains are functionally essential for von Willebrand factor cleavage.Blood2003;102(9):3232-7.
16 Porter S,Clark IM,Kevorkian L,Edwards DR.The ADAMTS metalloproteinases.Biochem J 2005;386(Pt 1):15-27.
17 Shindo T,Kurihara H,Kuno K,Yokoyama H,Wada T,Kurihara Y,et al.ADAMTS-1:A metalloproteinase-disintegrin essential for normal growth,fertility,and organ morphology and function.J Clin Invest 2000;105(10):1345-52.
18 Freitas VM,do Amaral JB,Silva TA,Santos ES,Mangone FR,Pinheiro Jde J,et al.Decreased expression of ADAMTS-1 in human breast tumors stimulates migration and invasion.Mol Cancer 2013;12:2.
19 Colige A,Sieron AL,Li SW,Schwarze U,Petty E,Wertelecki W,et al.Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I Nproteinase gene.Am J Hum Genet 1999;65(2):308-17.
20 Dubail J,Kesteloot F,Deroanne C,Motte P,Lambert V,Rakic JM,et al.ADAMTS-2 functions as anti-angiogenic and antitumoral molecule independently of its catalytic activity.Cell Mol Life Sci 2010;67(24):4213-32.
21 Verma P,Dalal K.ADAMTS-4 and ADAMTS-5:Key enzymes in osteoarthritis.J Cell Biochem 2011;112(12):3507-14.
22 Wagsater D,Bjork H,Zhu C,Bjorkegren J,Valen G,Hamsten A,et al.ADAMTS-4 and-8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques.Atherosclerosis 2008;196(2):514-22.
23 Nakada M,Miyamori H,Kita D,Takahashi T,Yamashita J,Sato H,et al.Human glioblastomas overexpress ADAMTS-5 that degrades brevican.Acta Neuropatho 2005;110(3):239-46.
24 Didangelos A,Mayr U,Monaco C,Mayr M.Novel role of ADAMTS-5 protein in proteoglycan turnover and lipoprotein retention in atherosclerosis.J Biol Chem 2012;287(23):19341-5.
25 Wang L,Zheng J,Bai X,Liu B,Liu CJ,Xu Q,et al.ADAMTS-7mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteries.Circ Res 2009;104(5):688-98.
26 Dunn JR,Reed JE,du Plessis DG,Shaw EJ,Reeves P,Gee AL,et al.Expression of ADAMTS-8,a secreted protease with antiangiogenic properties,is downregulated in brain tumours.Br J Cancer 2006;94(8):1186-93.
27 Ocak Z,Acar M,Gunduz E,Gunduz M,Demircan K,Uyeturk U,et al.Effect of hypericin on the ADAMTS-9 and ADAMTS-8gene expression in MCF7 breast cancer cells.Eur Rev Med Pharmacol Sci 2013;17(9):1185-90.
28 Sengle G,Tsutsui K,Keene DR,Tufa SF,Carlson EJ,Charbonneau NL,et al.Microenvironmental regulation by fibrillin-1.PLoS Genet 2012;8(1):e1002425.
29 Moncada-Pazos A,Obaya AJ,Llamazares M,Heljasvaara R,Suarez MF,Colado E,et al.ADAMTS-12 metalloprotease is necessary for normal inflammatory response.J Biol Chem 2012;287(47):39554-63.
30 Moncada-Pazos A,Obaya AJ,Fraga MF,Viloria CG,Capella G,Gausachs M,et al.The ADAMTS12 metalloprotease gene is epigenetically silenced in tumor cells and transcriptionally activated in the stroma during progression of colon cancer.J Cell Sci 2009;122 (Pt 16):2906-13.
31 El Hour M,Moncada-Pazos A,Blacher S,Masset A,Cal S,Berndt S,et al.Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis.Oncogene 2010;29(20):3025-32.
32 Johnston P,Chojnowski AJ,Davidson RK,Riley GP,Donell ST,Clark IM.A complete expression profile of matrix-degrading metalloproteinases in Dupuytren’s disease.J Hand Surg Am2007;32(3):343-51.
33 Molokwu CN,Adeniji OO,Chandrasekharan S,Hamdy FC,Buttle DJ.Androgen regulates ADAMTS15 gene expression in prostate cancer cells.Cancer Invest 2010;28(7):698-710.
34 Gao S,De Geyter C,Kossowska K,Zhang H.FSH stimulates the expression of the ADAMTS-16 protease in mature human ovarian follicles.Mol Hum Reprod 2007;13(7):465-71.
35 Morales J,Al-Sharif L,Khalil DS,Shinwari JM,Bavi P,AlMahrouqi RA,et al.Homozygous mutations in ADAMTS10 and ADAMTS17 cause lenticular myopia,ectopia lentis,glaucoma,spherophakia,and short stature.Am J Hum Genet 2009;85(5):558-68.
36 Aldahmesh MA,Khan AO,Mohamed JY,Alkuraya H,Ahmed H,Bobis S,et al.Identification of ADAMTS18 as a gene mutated in Knobloch syndrome.J Med Genet 2011;48(9):597-601.
37 Peluso I,Conte I,Testa F,Dharmalingam G,Pizzo M,Collin RW,et al.The ADAMTS18 gene is responsible for autosomal recessive early onset severe retinal dystrophy.Orphanet J Rare Dis2013;8:16.
38 Knauff EA,Franke L,van Es MA,van den Berg LH,van der Schouw YT,Laven JS,et al.Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene.Hum Reprod 2009;24(9):2372-8.
39 Liu CJ.The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis.Nat Clin Pract Rheumatol 2009;5(1):38-45.
40 Stanton H,Melrose J,Little CB,Fosang AJ.Proteoglycan degradation by the ADAMTS family of proteinases.Biochim Biophys Acta 2011;1812(12):1616-29.
41 Briggs MD,Hoffman SM,King LM,Olsen AS,Mohrenweiser H,Leroy JG,et al.Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene.Nat Genet1995;10(3):330-6.
42 Briggs MD,Mortier GR,Cole WG,King LM,Golik SS,Bonaventure J,et al.Diverse mutations in the gene for cartilage oligomeric matrix protein in the pseudoachondroplasia-multiple epiphyseal dysplasia disease spectrum.Am J Hum Genet 1998;62(2):311-9.
43 Cohn DH,Briggs MD,King LM,Rimoin DL,Wilcox WR,Lachman RS,et al.Mutations in the cartilage oligomeric matrix protein(COMP)gene in pseudoachondroplasia and multiple epiphyseal dysplasia.Ann N Y Acad Sci 1996;785:188-94.
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