ADAMTS家族在肿瘤中的研究进展
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摘要
近年来,含凝血酶敏感素基序的去整合素金属蛋白酶(ADAMTS)基因的异常表达与肿瘤的血管新生、发生发展以及淋巴结转移之间的关系成为很多学者的研究热点。诸多研究结果为寻找新型肿瘤标志物指明了方向,也为肿瘤分子靶向治疗提供了理论依据。该文就ADAMTS家族的结构、功能及其在肿瘤中的研究进展进行综述。
In recent years,the relationship between A disintegrin and metalloproteinase with thrombospondin( ADAMTS) gene abnormal expression and the tumor angiogenesis,occurrence,development,lymph node metastasis became a research hotspot for many scholars. Many research results pointed out the direction for finding new tumor markers,and also provided theoretical basis for molecular targeting therapy for cancer. Here is to make a review of the structure and function of the ADAMTS family and its research progress in tumor.
In recent years,the relationship between A disintegrin and metalloproteinase with thrombospondin( ADAMTS) gene abnormal expression and the tumor angiogenesis,occurrence,development,lymph node metastasis became a research hotspot for many scholars. Many research results pointed out the direction for finding new tumor markers,and also provided theoretical basis for molecular targeting therapy for cancer. Here is to make a review of the structure and function of the ADAMTS family and its research progress in tumor.
引文
[1]Seals DF,Courtneidge SA.The ADAMs family of metalloproteases:multidomain proteins with multiple functions[J].Genes Dev,2003,17(1):7-30.
[2]Porter S,Clark IM,Kevorkian L,et al.The ADAMTS metalloproteinases[J].Biochem J,2005,386(Pt 1):15-27.
[3]Clissa PB,Lopes-Ferreira M,Della-Casa MS,et al.Importance of jararhagin disintegrin-like and cysteine-rich domains in the early events of local inflammatory response[J].Toxicon,2006,47(5):591-596.
[4]Gantus MA,Nasciutti LE,Cruz CM,et al.Modulation of extracellular matrix components by metalloproteinases and their tissue inhibitors during degeneration and regeneration of rat sural nerve[J].Brain Res,2006,1122(1):36-46.
[5]Hurskainen TL,Hirohata S,Seldin MF,et al.ADAM-TS5,ADAMTS6,and ADAM-TS7,novel members of a new family of zinc metalloproteases.General features and genomic distribution of the ADAM-TS family[J].J Biol Chem,1999,274(36):25555-25563.
[6]Hanahan D,Folkman J.Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis[J].Cell,1996,86(3):353-364.
[7]Luque A,Carpizo DR,Iruela-Arispe ML.ADAMTS1/METH1inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165[J].J Biol Chem,2003,278(26):23656-23665.
[8]王利,王宪,孔炜.ADAMTS-7血管重塑中的新靶点[J].生理学报,2010,62(4):285-294.
[9]López-Otín C,Matrisian LM.Emerging roles of proteases in tumour suppression[J].Nat Rev Cancer,2007,7(10):800-808.
[10]Rocks N,Paulissen G,El Hour M,et al.Emerging roles of ADAM and ADAMTS metalloproteinases in cancer[J].Biochimie,2008,90(2):369-379.
[11]Llamazares M,Obaya AJ,Moncada-Pazos A,et al.The ADAMTS12metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signaling pathway[J].J Cell Sci,2007,120(Pt 20):3544-3552.
[12]陈静,戴冬秋,支宇,等.胃癌和转移淋巴结组织ADAMTS1表达及其生物学意义的探讨[J].中华肿瘤防治杂志,2012,19(1):53-56.
[13]Gach K,Szemraj J,Fichna J,et al.The influence of opioids on urokinase plasminogen activator on protein and mRNA level in MCF-7breast cancer cell line[J].Chem Biol Drug Des,2009,74(4):390-396.
[14]Masui T,Hosotani R,Tsuji S,et al.Expression of METH-1 and METH-2 in pancreatic cancer[J].Clin Cancer Res,2001,7(11):3437-3443.
[15]Gustavsson H,Wang W,Jennbacken K,et al.ADAMTS1,a putative anti-angiogenic factor,is decreased in human prostste cancer[J].BJU Int,2009,104(11):1786-1790.
[16]Choi JE,Kim DS,Kim EJ,et al.Aberrant methylation of ADAMTS1in non-small cell lung cancer[J].Cancer Genet Cytogenet,2008,187(2):80-84.
[17]Ahlquist T,Lind GE,Costa VL,et al.Gene methylation profiles of normal mucosa,and benign and malignant colorectal tumors identify early onset markers[J].Mol Cancer,2008,7:94.
[18]Lee YJ,Koch M,Karl D,et al.Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1[J].Cancer Res,2010,70(3):948-956.
[19]Rocks N,Paulissen G,Quesada-Calvo F,et al.ADAMTS-1 metalloproteinase promotes tumor development through the indction of a stromal reaction in vivo[J].Cancer Res,2008,68(22):9541-9550.
[20]Tyan SW,Hsu CH,Peng KL,et al.Breast cancer cells induce stromal fibroblasts to secrete ADAMTS1 for cancer invasion through an epigenetic change[J].PLoS One,2012,7(4):e35128.
[21]Esselens C,Malapeira J,ColoméN,et al.The cleavage of semaphoring 3C induced by ADAMTS1 promotes cell migration[J].J Biol Chem,2010,285(4):2463-2473.
[22]Lu X,Wang Q,Hu G,et al.ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis[J].Genes Dev,2009,23(16):1882-1894.
[23]Tyan SW,Kuo WH,Huang CK,et al.Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis[J].PLoS One,2011,6(1):e15313.
[24]Keightley MC,Sales KJ,Jabbour HN.PGF2α-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer[J].BMC Cancer,2010,10:488.
[25]Demircan K,Gunduz E,Gunduz M,et al.Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer[J].Head Neck,2009,31(6):793-801.
[26]Liu YJ,Xu Y,Yu Q.Full-length ADAMTS-1 and the ADAMTS-1fragments display pro-and antimetastatic activity,respectively[J].Oncogene,2006,25(17):2452-2467.
[27]Held-Feindt J,Paredes EB,Blmer U,et al.Matrix-degrading proteases ADAMTS4 and ADAMTS5(disintegrins and metalloproteinases with thrombospondin motifs 4 and 5)are expressed in human glioblastomas[J].Int J Cancer,2006,118(1):55-61.
[28]Dunn JR,Reed JE,du Plessls DG,et al.Expression of ADAMTS-8,a secreted protease with antiangrogenic properties,is downregulated in brain tumours[J].Br J Cancer,2006,94(8):1186-1193.
[29]Lung HL,Lo PH,Xie D,et al.Characterization of a novel epigenetically-silenced,growth-suppressive gene,ADAMTS9,and its association with lymph node metastases in nasopharyngeal carcinoma[J].Int J Cancer,2008,123(2):401-408.
[30]Mali AV,Wagh UV,Hegde MV,et al.In vitro anti-metastatic activity of enterolactone,a mammalian lignan derived from flax lignan,and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines[J].Indian J Cancer,2012,49(1):181-187.
[31]El Hour M,Moncada-Pazos A,Blacher S,et al.Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis[J].Oncogene,2010,29(20):3025-3032.
[32]Wang D,Zhu T,Zhang FB,et al.Expression of ADAMTS12 in colorectal cancer-associated stroma prevents cancer development and is a good prognostic indicator of colorectal cancer[J].Dig Dis Sci,2011,56(11):3281-3287.
[33]Gao WQ,Su J,Bai X,et al.Evaluation of von Willebrand factorcleaving protease activity in patients with thrombotic thrombocytopenic purpura[J].Chin Med J(Engl),2004,117(6):818-822.
[34]Koo BH,Oh D,Chunq SY,et al.Deficiency of von Willebrand factor-cleaving protease activity in the plasma of malignant patients[J].Thromb Res,2002,105(6):471-476.
[35]Kuefer R,Day KC,Kleer CG,et al.ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease[J].Neoplasia,2006,8(4):319-329.
[36]Viloria CG,Obaya AJ,Moncada-Pazos A,et al.Genetic inactivationof ADAMTS15 metalloprotease in human colorectal cancer[J].Cancer Res,2009,69(11):4926-4934.
[37]Xiong DH,Liu XG,Guo YF,et al.Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3as bone mass candidate genes in different ethnic groups[J].Am J Hum Genet,2009,84(3):388-398.
[38]Jin H,Wang X,Ying J,et al.Epigenetic identification of ADAMTS18as a novel 16q23.1 tumor suppressor frequently silenced in esophageal,nasopharyngeal and multiple other carcinomas[J].Oncogene,2007,26(53):7490-7498.
[39]Wei X,Prickett TD,Viloria CG,et al.Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma[J].Mol Cancer Res,2010,8(11):1513-1525.
[40]Silver DL,Hou L,Somerville R,et al.The secreted metalloprotease ADAMTS20 is required for melanoblast survival[J].PLoS Genet,2008,4(2):e1000003.
[2]Porter S,Clark IM,Kevorkian L,et al.The ADAMTS metalloproteinases[J].Biochem J,2005,386(Pt 1):15-27.
[3]Clissa PB,Lopes-Ferreira M,Della-Casa MS,et al.Importance of jararhagin disintegrin-like and cysteine-rich domains in the early events of local inflammatory response[J].Toxicon,2006,47(5):591-596.
[4]Gantus MA,Nasciutti LE,Cruz CM,et al.Modulation of extracellular matrix components by metalloproteinases and their tissue inhibitors during degeneration and regeneration of rat sural nerve[J].Brain Res,2006,1122(1):36-46.
[5]Hurskainen TL,Hirohata S,Seldin MF,et al.ADAM-TS5,ADAMTS6,and ADAM-TS7,novel members of a new family of zinc metalloproteases.General features and genomic distribution of the ADAM-TS family[J].J Biol Chem,1999,274(36):25555-25563.
[6]Hanahan D,Folkman J.Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis[J].Cell,1996,86(3):353-364.
[7]Luque A,Carpizo DR,Iruela-Arispe ML.ADAMTS1/METH1inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165[J].J Biol Chem,2003,278(26):23656-23665.
[8]王利,王宪,孔炜.ADAMTS-7血管重塑中的新靶点[J].生理学报,2010,62(4):285-294.
[9]López-Otín C,Matrisian LM.Emerging roles of proteases in tumour suppression[J].Nat Rev Cancer,2007,7(10):800-808.
[10]Rocks N,Paulissen G,El Hour M,et al.Emerging roles of ADAM and ADAMTS metalloproteinases in cancer[J].Biochimie,2008,90(2):369-379.
[11]Llamazares M,Obaya AJ,Moncada-Pazos A,et al.The ADAMTS12metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signaling pathway[J].J Cell Sci,2007,120(Pt 20):3544-3552.
[12]陈静,戴冬秋,支宇,等.胃癌和转移淋巴结组织ADAMTS1表达及其生物学意义的探讨[J].中华肿瘤防治杂志,2012,19(1):53-56.
[13]Gach K,Szemraj J,Fichna J,et al.The influence of opioids on urokinase plasminogen activator on protein and mRNA level in MCF-7breast cancer cell line[J].Chem Biol Drug Des,2009,74(4):390-396.
[14]Masui T,Hosotani R,Tsuji S,et al.Expression of METH-1 and METH-2 in pancreatic cancer[J].Clin Cancer Res,2001,7(11):3437-3443.
[15]Gustavsson H,Wang W,Jennbacken K,et al.ADAMTS1,a putative anti-angiogenic factor,is decreased in human prostste cancer[J].BJU Int,2009,104(11):1786-1790.
[16]Choi JE,Kim DS,Kim EJ,et al.Aberrant methylation of ADAMTS1in non-small cell lung cancer[J].Cancer Genet Cytogenet,2008,187(2):80-84.
[17]Ahlquist T,Lind GE,Costa VL,et al.Gene methylation profiles of normal mucosa,and benign and malignant colorectal tumors identify early onset markers[J].Mol Cancer,2008,7:94.
[18]Lee YJ,Koch M,Karl D,et al.Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1[J].Cancer Res,2010,70(3):948-956.
[19]Rocks N,Paulissen G,Quesada-Calvo F,et al.ADAMTS-1 metalloproteinase promotes tumor development through the indction of a stromal reaction in vivo[J].Cancer Res,2008,68(22):9541-9550.
[20]Tyan SW,Hsu CH,Peng KL,et al.Breast cancer cells induce stromal fibroblasts to secrete ADAMTS1 for cancer invasion through an epigenetic change[J].PLoS One,2012,7(4):e35128.
[21]Esselens C,Malapeira J,ColoméN,et al.The cleavage of semaphoring 3C induced by ADAMTS1 promotes cell migration[J].J Biol Chem,2010,285(4):2463-2473.
[22]Lu X,Wang Q,Hu G,et al.ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis[J].Genes Dev,2009,23(16):1882-1894.
[23]Tyan SW,Kuo WH,Huang CK,et al.Breast cancer cells induce cancer-associated fibroblasts to secrete hepatocyte growth factor to enhance breast tumorigenesis[J].PLoS One,2011,6(1):e15313.
[24]Keightley MC,Sales KJ,Jabbour HN.PGF2α-F-prostanoid receptor signalling via ADAMTS1 modulates epithelial cell invasion and endothelial cell function in endometrial cancer[J].BMC Cancer,2010,10:488.
[25]Demircan K,Gunduz E,Gunduz M,et al.Increased mRNA expression of ADAMTS metalloproteinases in metastatic foci of head and neck cancer[J].Head Neck,2009,31(6):793-801.
[26]Liu YJ,Xu Y,Yu Q.Full-length ADAMTS-1 and the ADAMTS-1fragments display pro-and antimetastatic activity,respectively[J].Oncogene,2006,25(17):2452-2467.
[27]Held-Feindt J,Paredes EB,Blmer U,et al.Matrix-degrading proteases ADAMTS4 and ADAMTS5(disintegrins and metalloproteinases with thrombospondin motifs 4 and 5)are expressed in human glioblastomas[J].Int J Cancer,2006,118(1):55-61.
[28]Dunn JR,Reed JE,du Plessls DG,et al.Expression of ADAMTS-8,a secreted protease with antiangrogenic properties,is downregulated in brain tumours[J].Br J Cancer,2006,94(8):1186-1193.
[29]Lung HL,Lo PH,Xie D,et al.Characterization of a novel epigenetically-silenced,growth-suppressive gene,ADAMTS9,and its association with lymph node metastases in nasopharyngeal carcinoma[J].Int J Cancer,2008,123(2):401-408.
[30]Mali AV,Wagh UV,Hegde MV,et al.In vitro anti-metastatic activity of enterolactone,a mammalian lignan derived from flax lignan,and down-regulation of matrix metalloproteinases in MCF-7 and MDA MB 231 cell lines[J].Indian J Cancer,2012,49(1):181-187.
[31]El Hour M,Moncada-Pazos A,Blacher S,et al.Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis[J].Oncogene,2010,29(20):3025-3032.
[32]Wang D,Zhu T,Zhang FB,et al.Expression of ADAMTS12 in colorectal cancer-associated stroma prevents cancer development and is a good prognostic indicator of colorectal cancer[J].Dig Dis Sci,2011,56(11):3281-3287.
[33]Gao WQ,Su J,Bai X,et al.Evaluation of von Willebrand factorcleaving protease activity in patients with thrombotic thrombocytopenic purpura[J].Chin Med J(Engl),2004,117(6):818-822.
[34]Koo BH,Oh D,Chunq SY,et al.Deficiency of von Willebrand factor-cleaving protease activity in the plasma of malignant patients[J].Thromb Res,2002,105(6):471-476.
[35]Kuefer R,Day KC,Kleer CG,et al.ADAM15 disintegrin is associated with aggressive prostate and breast cancer disease[J].Neoplasia,2006,8(4):319-329.
[36]Viloria CG,Obaya AJ,Moncada-Pazos A,et al.Genetic inactivationof ADAMTS15 metalloprotease in human colorectal cancer[J].Cancer Res,2009,69(11):4926-4934.
[37]Xiong DH,Liu XG,Guo YF,et al.Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3as bone mass candidate genes in different ethnic groups[J].Am J Hum Genet,2009,84(3):388-398.
[38]Jin H,Wang X,Ying J,et al.Epigenetic identification of ADAMTS18as a novel 16q23.1 tumor suppressor frequently silenced in esophageal,nasopharyngeal and multiple other carcinomas[J].Oncogene,2007,26(53):7490-7498.
[39]Wei X,Prickett TD,Viloria CG,et al.Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanoma[J].Mol Cancer Res,2010,8(11):1513-1525.
[40]Silver DL,Hou L,Somerville R,et al.The secreted metalloprotease ADAMTS20 is required for melanoblast survival[J].PLoS Genet,2008,4(2):e1000003.