神黄豆茎叶中酚性成分研究
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摘要
对傣药决明属植物神黄豆(Cassia agnes Brenan)茎叶的化学成分进行研究.运用硅胶、HPLC等多种色谱技术从傣药神黄豆90%乙醇提取物中分离得到10个单体化合物.化合物1～9为黄酮类化合物.根据化合物的理化性质及波谱数据分析,将其分别鉴定为:山奈酚-3-O-α-L-鼠李糖苷(1),桑色素-3-O-α-鼠李糖苷(2),山奈酚(3), 5, 7, 3′, 4′-四羟基黄酮(4), 3-甲氧基槲皮素(5), 3, 5, 7, 3′, 4′-五羟基黄酮(6),表阿夫儿茶精(7),表儿茶素(8),表儿茶素-(4β→8′)-表儿茶素(9),原儿茶酸(10).其中,1～6、8和10为首次从该植物中分离得到.
A total of ten compounds were isolated from the 90% EtOH extract of Cassia agnes Brenan by using various chromatographic techniques. The structures of these compounds were established as kaempferol-3-O-α-L-rhamnopyranoside(1), morin-3-O-α-rhamnopyranoside(2), kaempferol(3), 5, 7, 3′, 4′-tetrahydroxyflavone(4), 3-O-methylquercetin(5), 3, 5, 7, 3′,4′-pentahydroxyflavonone(6),(-)-epiafzelechin(7), epicatechin(8), epicatechin-(4β→8′)-epicatechin(9), prptocatechuate(10). Compounds 1—6、8 and 10 were isolated from this plant for the first time.
A total of ten compounds were isolated from the 90% EtOH extract of Cassia agnes Brenan by using various chromatographic techniques. The structures of these compounds were established as kaempferol-3-O-α-L-rhamnopyranoside(1), morin-3-O-α-rhamnopyranoside(2), kaempferol(3), 5, 7, 3′, 4′-tetrahydroxyflavone(4), 3-O-methylquercetin(5), 3, 5, 7, 3′,4′-pentahydroxyflavonone(6),(-)-epiafzelechin(7), epicatechin(8), epicatechin-(4β→8′)-epicatechin(9), prptocatechuate(10). Compounds 1—6、8 and 10 were isolated from this plant for the first time.
引文
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[7] 邓双炳, 菅晓勇, 任启生,等. 旋覆花化学成分研究[J]. 中国现代应用药学, 2011, 28(4):331-334.
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[10] MIRI K R, HWANG B Y, LIN H S, el al. (-)-Epiafzelechin:cyclooxygenase-1 inhibitor and anti-inflammatory agent from aerial parts of Celastrus orbiculatus[J]. Planta Medica, 1999, 65(05): 460-462.
[11] 胡江苗,陈纪军,赵友兴,等. 山竺果壳的化学成分[J]. 云南植物研究,2006, 28(3):319-322.
[12] 王暐,杨崇仁,张颖君,等. 草果果实中的酚性成分[J]. 云南植物研究,2009, 31(3):284-288.
[2] 黄波, 黄振元,武拉斌,等. 神黄豆化学成分研究[J]. 天然产物研究与开发, 2012, 4(24):437-439.
[3] 和东阳, 王利勤. 神黄豆果实化学成分的研究[J]. 中国现代应用药学, 2014,31(11):1355-1359.
[4] MASUDA T, JITOE A,KATO S,et al. Acetylated flavonol glycosides from Zingiber zerumbet[J]. phytochemistry, 1991, 30(7):2391-2392.
[5] YEN C T, HSIEN P W, HWANG T L,et al. Flavonol glycosides from Muehlenbeckia platyclada and their anti-inflammatory activity[J]. Chemical and Pharmaceutical Bulletin, 2009, 57(3):280-282.
[6] BARRETO M B, GOMES C L,FREITAS J V B,et al. Flavonoids and terpenoids from Croton muscicarpa (Euphorbiaceae)[J]. Quimica Nova, 2013, 36(5):675-679.
[7] 邓双炳, 菅晓勇, 任启生,等. 旋覆花化学成分研究[J]. 中国现代应用药学, 2011, 28(4):331-334.
[8] ALQASOUMI S I. Phytochemical study of the aerial parts of conyza discorridis growing in saudi arabia[J]. Nature Product Sciences, 2009, 15(2):66-70.
[9] 易进海, 张国林, 李伯刚. 黄杉化学成分的研究[J]. 药学学报, 2002, 37(5):352-354.
[10] MIRI K R, HWANG B Y, LIN H S, el al. (-)-Epiafzelechin:cyclooxygenase-1 inhibitor and anti-inflammatory agent from aerial parts of Celastrus orbiculatus[J]. Planta Medica, 1999, 65(05): 460-462.
[11] 胡江苗,陈纪军,赵友兴,等. 山竺果壳的化学成分[J]. 云南植物研究,2006, 28(3):319-322.
[12] 王暐,杨崇仁,张颖君,等. 草果果实中的酚性成分[J]. 云南植物研究,2009, 31(3):284-288.